Changes

===Pathogenesis of ESRD===

===Pathogenesis of ESRD===

When any pathological changes occur in kidney, initially there is hyperfiltration leading to minor damages to the kidney. Because of this hyper filtration, there is over burden to the remaining healthy nephrons to compensate it. This causes further damage in the healthy nephrons and progressive dysfunction ultimately leading to ESRD. Initially it will be evidenced by biochemical abnormalities, but gradually it leads to excretory, metabolic and endocrinal deficiencies related to the functions of kidney.

When any pathological changes occur in kidney, initially there is hyperfiltration leading to minor damages to the kidney. Because of this hyperfiltration, there is over burden to the remaining healthy nephrons to compensate it. This causes further damage in the healthy nephrons and progressive dysfunction ultimately leading to ESRD. Initially it will be evidenced by biochemical abnormalities, but gradually it leads to excretory, metabolic and endocrinal deficiencies related to the functions of kidney.

===Etiological factors===

===Etiological factors===