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#''Sthana-Smashrya'' (Localization): The circulating ''dosha'' interacts with such tissues which have some problem in their channels which may be anatomical, physiological or pathological. This phenomenon is ''dosha-dushya-samurchchana''. This localization of ''dosha'' leads to beginning of the pathogenesis of the disease and during this stage prodromal symptoms (''purva-rupa'') of the disease are produced. The prodromal symptoms of edema are heat, burning sensation and dilation of the vessels.
 
#''Sthana-Smashrya'' (Localization): The circulating ''dosha'' interacts with such tissues which have some problem in their channels which may be anatomical, physiological or pathological. This phenomenon is ''dosha-dushya-samurchchana''. This localization of ''dosha'' leads to beginning of the pathogenesis of the disease and during this stage prodromal symptoms (''purva-rupa'') of the disease are produced. The prodromal symptoms of edema are heat, burning sensation and dilation of the vessels.
 
#''Vyakti'' (Manifestation): If the disease is not managed at the stage of localization then the disease manifest with its specific symptoms. The symptoms of various types of edema are mentioned in the verses from 11 to 16 of this chapter. All or few symptoms mentioned for the disease may appear but if all the symptoms appear then the disease may become incurable and if few then it is easily curable. Moderate appearance of the symptom indicates its moderate prognosis.  
 
#''Vyakti'' (Manifestation): If the disease is not managed at the stage of localization then the disease manifest with its specific symptoms. The symptoms of various types of edema are mentioned in the verses from 11 to 16 of this chapter. All or few symptoms mentioned for the disease may appear but if all the symptoms appear then the disease may become incurable and if few then it is easily curable. Moderate appearance of the symptom indicates its moderate prognosis.  
#''Bheda'' (Complications): If the disease is not properly treated even after it is fully manifestation then the complications may appear and the disease becomes difficult to cure or incurable. The seven complications of edema are vomiting, thirst, anorexia, dyspnea, fever, diarrhea and weakness ([[Sutra Sthana]] 18:18).
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#''Bheda'' (Complications): If the disease is not properly treated even after it is fully manifestation then the complications may appear and the disease becomes difficult to cure or incurable. The seven complications of edema are vomiting, thirst, anorexia, dyspnea, fever, diarrhea and weakness [ Cha. Sa. [[Sutra Sthana]] 18/18].
    
=== Differential Diagnosis of ''shotha'' ===
 
=== Differential Diagnosis of ''shotha'' ===
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