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<li>The innermost endometrium lining of the uterus shows cyclical changes that lead to forming a bed for the implantation and nourishment of the developing fetus.</li></ol>
<li>The innermost endometrium lining of the uterus shows cyclical changes that lead to forming a bed for the implantation and nourishment of the developing fetus.</li></ol>
== Application of kala in agada tantra (forensic medicine and toxicology) ==
<p style='text-align:justify;'>The snake poison successively attacks the seven kala and gives rise to seven poisoning stages. The patient's prognosis with the snake bite depends on the presence of toxin in the respective kala. [Su. Ka.4/39] <br/>In the first phase, the poison vitiates blood, due to which it becomes black and hence causes blackening of skin and feeling as ‘ants are crawling on the body’. <br/>In the second phase, it vitiates muscles, which gives rise to marked blackness, inflammation, and cyst in the body. <br/>In the third phase, it vitiates fat which causes moistening of the bite site, heaviness of the head, and stiffness of eyes. In the fourth phase, the poison enters the thoraco-abdominal cavity. It vitiates dosha, predominantly kapha, which produces drowsiness, salivation, and weakness in joints. <br/>In the fifth phase, it further penetrates bones. It vitiates prana and agni, leading to joint pain, hiccoughs, and a burning sensation. In the sixth phase, it reaches the bone marrow. It highly vitiates the small intestine (grahani) which gives rise to heaviness in the body, diarrhea, cardiac pain, and fainting. In the seventh phase, it enters into semen (shukra) and highly vitiates vyanavayu. It causes the discharge of kapha from minute channels, leading to breaking pain in the waist and back, loss of all movements, excessive salivation and sweating, and finally, death due to respiratory arrest. [Su.Sa.KalpaSthana4/39] <br/>As the snake venom passes deeper into various tissues (dhatus) by piercing several kalas, the patient's prognosis become more and more critical. </p>
== Contemporary approach ==
<p style='text-align:justify;'>In corelation with contemporary science the term kala can be corelate with various serous or mucosal membranes. Mamsadhara kala includes the innermost layer of skin i.e., dermis (mamsadharatwacha), superficial and deep fascia intermuscular septum, epimysium, perimysium, and endomysium. The raktadhara kala allows blood to flow through various blood vessels, capillary network, and sinusoids in the liver and spleen. The tunica intima of blood vessels can be considered raktadhara kala.Medodhatu is present over the entire body especially it is appreciated in the region of abdomen in the form of omentum, mesentery, and mesocolon. It can also be correlated with the endosteum of the bones. <br/>Similarly the shleshmadhara kala can be correlated with synovial fluid and membrane of the joints.Purishadhara kala can be correlated with mucosal membrane of the gastro-intestinal tract especially in the region of large intestine. The pittadharakala can be correlated with the epithelium of digestive glands, enzymes, mucous membrane of the digestive tube, its villi, and lacteals responsible for digestion.Shukradhara kala can be correlated with the inner lining of the seminal vesicle, ejaculatory duct, vas difference, epididymis, and seminiferous tubule in the testis.</p>
== Future scope of research in kala sharira ==
<p style='text-align:justify;'>From the treatment point of view, the knowledge of kala shariraproved to be of utmost importance as the site beholds the specific organ.It also reflectsthe effect on dhatu. Intestinal resection may lead to certain disorders,such as improper digestion and poor absorption of nutrients.Hence it may cause loss of bone density and affect physical and mental health. To reduce such complications, tiktakshirabasti(enema with medicated milk and ghee) may be beneficial. The various psychological disorders can affect the enteric nervous system closely related to pittadharaand purishdhara kala. So, in such cases, psychological consideration should be at its utmost priority.Hence it can be concluded that there is wide scope for research to study cellular changes at the level of kala with the use of modern technologies.</p>
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