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Dhatvagni, in general, represents the process of tissue metabolism and assimilation. Different types of wholesome foods ingested in the form of eatables, drinkables, lickables and masticables stimulate digestion (antaragni). They are further digested by respective bhutagni (specific digestion per primary constituent or element). In due course of time, food gets transformed into different [[dhatu]] in the presence of dhatvagni (tissue-specific digestion and metabolism) [A.H.Sharira Sthana 3/62]<ref name=Hridaya/> and [[vata]] (vyanavayu) by the process of dhatvagnipaka. [A.S.Sharira Sthana 6]<ref name=Sangraha/> It nourishes the tissues through channels of circulation without interruption and produces plumpness, strength, complexion, health, and longevity. The tissues are sustained by getting fed by various nourishing factors (poshaka dhatu). Thus, it plays a vital role in maintaining the digestive physiology and assimilation in the body. [Cha.Sa.[[Sutra Sthana]] 28/3] Therefore, the whole genesis, metabolism, functioning and elimination of [[dhatu]] are dependent on this process of dhatvagnipaaka. [Cha.Sa.[[Sutra Sthana]] 28/3] Hence, it is the basis of the ksheeradadhinyaya (law of complete transformation of one substance to other like milk into curd) and kedarikulyanyaya (sequential transformation of tissues just like canals in a farm). This depicts the [[dhatu]] metabolism. [Chakrapani on Cha.Sa.[[Chikitsa Sthana]] 15/16] Thus, the systematic nourishment of [[dhatu]] (dhatusnehaparampara) is maintained through dhatvagni. [Cha.Sa.[[Chikitsa Sthana]] 15/19][Arunadatta on A.H.Sharira Sthana 3/70]<ref name=Hridaya/>
Dhatvagni, in general, represents the process of tissue metabolism and assimilation. Different types of wholesome foods ingested in the form of eatables, drinkables, lickables and masticables stimulate digestion (antaragni). They are further digested by respective bhutagni (specific digestion per primary constituent or element). In due course of time, food gets transformed into different [[dhatu]] in the presence of dhatvagni (tissue-specific digestion and metabolism) [A.H.Sharira Sthana 3/62]<ref name=Hridaya/> and [[vata]] (vyanavayu) by the process of dhatvagnipaka. [A.S.Sharira Sthana 6]<ref name=Sangraha/> It nourishes the tissues through channels of circulation without interruption and produces plumpness, strength, complexion, health, and longevity. The tissues are sustained by getting fed by various nourishing factors (poshaka dhatu). Thus, it plays a vital role in maintaining the digestive physiology and assimilation in the body. [Cha.Sa.[[Sutra Sthana]] 28/3] Therefore, the whole genesis, metabolism, functioning and elimination of [[dhatu]] are dependent on this process of dhatvagnipaaka. [Cha.Sa.[[Sutra Sthana]] 28/3] Hence, it is the basis of the ksheeradadhinyaya (law of complete transformation of one substance to other like milk into curd) and kedarikulyanyaya (sequential transformation of tissues just like canals in a farm). This depicts the [[dhatu]] metabolism. [Chakrapani on Cha.Sa.[[Chikitsa Sthana]] 15/16] Thus, the systematic nourishment of [[dhatu]] (dhatusnehaparampara) is maintained through dhatvagni. [Cha.Sa.[[Chikitsa Sthana]] 15/19][Arunadatta on A.H.Sharira Sthana 3/70]<ref name=Hridaya/>
==Importance of the concept of dhatvagni in understanding disease pathology and disease treatment==
[[Agni]] is the physiological entity responsible for the status of [[dosha]]. [Cha.Sa.[[Chikitsa Sthana]]5/136] The dhatvagni being a part of this [[agni]] component, is thus equally responsible in the maintenance of health and even in the affliction of diseases. The dhatvagni is a determinant of the production and functions of [[dhatu]]. Hence its proper functioning is of utmost importance in health. Imbalance can lead to disease manifestation. For instance, in condition like [[raktapitta]], the excessive [[pitta]] is responsible for the overstimulation of [[agni]] and dhatvagni, leading to the depletion of quality of [[rakta dhatu]] and liquidity (dravana).[Cha.Sa.[[Chikitsa Sthana]] 4/8] Here the dhatvagni is overstimulated, leading to an imbalance in the tissue metabolism. Also, in conditions like obesity (sthoulya), the [[meda dhatu]] metabolism weakens, leading to excessive [[meda]] (fat deposition). Undernourishment of the remaining [[dhatu]] depicts the slow metabolism of meda (meda-dhatvagnimandya) in the body. [Cha.Sa.[[Sutra Sthana]] 21/5-8]
In the disease [[rajayakshma]], depletion of [[dhatu]] is observed. Dhatvagni plays a pivotal role in the pathological process.[Cha.Sa.[[Chikitsa Sthana]] 8/39-40] The text mentions the term' ushma' in various instances while explaining the metabolism and formation of different [[dhatu]] ([[rakta dhatu]], [[mamsa dhatu]], [[asthi dhatu]]). [Cha.Sa.[[Chikitsa Sthana]] 15/28-31] This concept is also applicable in the pathogenesis of [[pandu]] roga, where the nourishment of [[dhatu]] is hampered leading to laxity and heaviness of [[dhatu]] (dhatushaithilya and dhatugaurava). The quality of the rasa-raktadi dhatu is hampered to a great extent in this condition.[Cha.Sa.[[Chikitsa Sthana]] 16/4-6] The dhatugata disorders are result of dysfunctions of dhatvagni. Dhatvagni is responsible for breakdown (bhinnasanghata), oxidation (dahana) leading to heat or energy generation (tapana).
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