Changes

#A study of dhatvagni with special reference to hypothyroidism depicted that abnormality at the level of [[meda dhatu]] (medodhatvagni vikriti) may be the cause of endocrinal disturbance related to thyroid gland functions. Secondly the excessive illumination of dhatwagni may cause rise in anabolism and catabolism.<ref>Sharma DV, Sharir MDK. STUDY OF DHATWAGNI VIKRITI W.S.R. TO HYPOTHYROIDISM. World Journal of Pharmaceutical Research. 10(5):10.</ref> Another study showed that the the clinical features of low dhatvagni functions (dhatvagnimandya) like slower metabolism (agninasha),  pallor (pandutwam), oligomenorrhoea (artavanasha), cold intolerance (sheetaasatmya) etc. can be correlated with symptoms of Hypothyroidism.<ref>??</ref>

#A study of dhatvagni with special reference to hypothyroidism depicted that abnormality at the level of [[meda dhatu]] (medodhatvagni vikriti) may be the cause of endocrinal disturbance related to thyroid gland functions. Secondly the excessive illumination of dhatwagni may cause rise in anabolism and catabolism.<ref>Sharma DV, Sharir MDK. STUDY OF DHATWAGNI VIKRITI W.S.R. TO HYPOTHYROIDISM. World Journal of Pharmaceutical Research. 10(5):10.</ref> Another study showed that the the clinical features of low dhatvagni functions (dhatvagnimandya) like slower metabolism (agninasha),  pallor (pandutwam), oligomenorrhoea (artavanasha), cold intolerance (sheetaasatmya) etc. can be correlated with symptoms of Hypothyroidism.<ref>??</ref>

#Selective production and transformation of [[dhatu]] is explained. Each dhatvagni synthesize and transform the constituents suitable to its particular [[dhatu]] as a part of selective action.<ref>Agrawal AK, Yadav CR, Meena MS. Physiological aspects of Agni. Ayu. 2010;31(3):395–8.</ref>   

#Selective production and transformation of [[dhatu]] is explained. Each dhatvagni synthesize and transform the constituents suitable to its particular [[dhatu]] as a part of selective action.<ref>Agrawal AK, Yadav CR, Meena MS. Physiological aspects of Agni. Ayu. 2010;31(3):395–8.</ref>   

7. The inter-relationship between jatharagniand dhatvagniin the manifestation of different diseasesis established. Agniare connected with each other and due to this relationship, vitiation of jatharagniresults in vitiation of all the other agni.  

#The inter-relationship between jatharagni and dhatvagni in the manifestation of different diseases is established. [[Agni]] are connected with each other and due to this relationship, vitiation of jatharagni results in vitiation of all the other [[agni]].<ref>Satani DKG, Raghvani H, Bhatt K. Interrelationship of Jatharagni and Dhatvagni in context to Dhatvagni Pradoshaj Vikaras. Journal of Ayurveda and Integrated Medical Sciences. 2017 Feb 28;2(01):180–5.</ref>

8. The inter relationship between the occurrence of ama,dhatvagnimandyaand their role in manifestation of diseases is observed invarious diseases. In metabolic disorders like amavata, medoroga, prameha, sthaulya, etc. the role of ama and dhatvagniis very important.  

#The inter relationship between the occurrence of [[ama]], dhatvagnimandya and their role in manifestation of diseases is observed in various diseases. In metabolic disorders like [[amavata]], medoroga, [[prameha]], [[sthaulya]], etc. the role of [[ama]] and dhatvagni is very important.<ref>Shaikh JG, Burley AK, Deshmukh SG. Concept of Aama and Dhatvagni in Ayurveda. International Journal of Ayurveda. 2021 Feb 23;(0):15–7.</ref>

9. The role of dhatvagnimandyain the occurrence of various upadhatujanyavikara is discussed.   Any kind  of  vitiation  to  the  status  of   agni or dhatvagni, srotasand vataleads to manifestation of  upadhatupradoshajavikara.

#The role of dhatvagnimandya in the occurrence of various upadhatujanyavikara is discussed. Any kind  of  vitiation  to  the  status  of [[agni]] or dhatvagni, [[srotas]] and [[vata]] leads to manifestation of  upadhatupradoshajavikara.<ref>Gupta M. Understanding of Upadhatu Pradoshaja Vikara. Journal of Ayurveda and Integrated Medical Sciences. 2021 Sep 15;6(4):337–9.</ref>

  In process

 

Dhatvagni can be considered as an intermediate metabolism in contemporary light.<ref>C Dwarkanath, Digestion and Metabolism in Ayurveda, Section 2, reprinted 2010, Published by Chaukahmaba Krishnadas Academy, Varanasi, Page No. 126</ref> It is the conglomeration of sum of all intracellular chemical processes by which the nutritive material is converted into cellular matter.<ref>Veerappa S, McClure J. Intermediary metabolism. Anaesthesia & Intensive Care Medicine. 2020 Mar 1;21(3):162–7.</ref> Cellular energy is generated from aerobic oxidation of metabolic fuels (carbohydrates, fats, proteins) derived from the digestion of a meal or the breakdown of internal stores. These can also be compared with enzymes, the biocatalysts that speed up the biochemical reactions in living organisms.<ref>Robinson PK. Enzymes: principles and biotechnological applications. Essays Biochem. 2015 Nov 15; 59:1–41.</ref> The enzymes have varied actions depending upon the site of action and predicted function, also termed as the specificity of the enzyme.<ref>Hedstrom L. Enzyme Specificity and Selectivity. In: eLS [Internet]. John Wiley & Sons, Ltd; 2010 [cited 2022 Jul 14]. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1002/9780470015902.a0000716.pub2</ref> Hence, the different types of enzymes have specific types of action based on the substrate diet taken. For instance, there are various enzymes like splitting enzymes (hydrolases), transferring enzymes (oxidases, reductases), and isomerases involved in the process of digestion.<ref>Patricia JJ, Dhamoon AS. Physiology, Digestion. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 [cited 2022 Jul 14]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK544242/</ref> These can be compared with the functions of [[pitta dosha]] like breaking down particles (sanghatabheda), transformation (parinama), catalyst (pravritti) etc.<ref>??</ref> Dhatvagnipaaka can also be compared with the concepts of pilupaakavaada and pitharapaakavadaas put forth by the Nyaya-Vaisheshika philosophy. The pilupaka confers to the chemical transformation, while pitharapaka to the physical transformation.<ref>??</ref> The processes of metabolism, catabolism and anabolism are also closely related to the dhatvagnipaaka. The metabolism is a series of all the reactions that happen at the cellular level. Catabolism is the breakdown or the degradation of complex macromolecules, while anabolism synthesizes the macromolecules and tissues.<ref>Judge A, Dodd MS. Metabolism. Essays Biochem. 2020 Oct;64(4):607–47.</ref> More research on the relation between dhatvagni and specific digestive processes can provide new insights into understanding the physiology and management of diseases.