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<li>New drugs should be introduced only if they offer distinct advantages over drugs previously selected.</li>
<li>New drugs should be introduced only if they offer distinct advantages over drugs previously selected.</li>
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=== Protocol after ingestion of aushadha ===
<div style='text-align:justify;'>There are some medicines, to which some individuals become habituated on continuous consumption. For example, a number of investigators have described withdrawal symptoms after the abrupt cessation of meprobamate treatment.<ref>HAIZLIP TM, EWING JA. Meprobamate habituation: a controlled clinical study. N Engl J Med. 1958 Jun;258(24) 1181-1186. doi:10.1056/nejm195806122582401. PMID: 13552940.</ref> The abrupt discontinuation of aushadha may lead to withdrawl symptoms. Thus, after subsidence of disease, the aushadha should be given for further one, two or three days according to the strength.<ref>Satyapala, editor, (1st ed.). Commentary Vidyotini of Kashyap Samhita, Khila Sthana; Bheshajyopakramaniya Adhyaya: Chapter 3, Verse 64. Varanasi: Chaukhamba Sanskrit Sansthan, 2015; 370.</ref> Person to whom aushadha is administered must avoid excess walking, standing, sleeping, sitting and talking, anger, grief, day sleeping, use of contrary cereals, use of cold and heat and intercourse just after ingestion of aushadha.<ref>Satyapala, editor, (1st ed.). Commentary Vidyotini of Kashyap Samhita, Khila Sthana; Bheshajyopakramaniya Adhyaya: Chapter 3, Verse 67-68. Varanasi: Chaukhamba Sanskrit Sansthan, 2015; 370.</ref> Signs indicative of digestion of aushadha are yawning, aversion to sound, dryness of mouth, disquietude, tiredness, drowsiness, cramps and lethargy.<ref>Satyapala, editor, (1st ed.). Commentary Vidyotini of Kashyap Samhita, Khila Sthana; Bheshajyopakramaniya Adhyaya: Chapter 3, Verse 69. Varanasi: Chaukhamba Sanskrit Sansthan, 2015; 371.</ref></div>
=== Variation of potency of aushadha with season ===
<div style='text-align:justify;'>The potency of aushadha varies with season, which consequently causes variation in the dose.During rainy season, the body becomes weak due to the effect of season (aadana kala). The naturally available aushadha is also poor in potency, their roots being submerged in water, the water being contaminated with cadavers, tissues, urine and excreta of birds and animals. Thus administration of aushadha in rainy season is unsuitable for the health of the person.<ref>Tripathi R.D., (1 st ed.). Commentary Saroj on Astanga Sangrah of Vridhavagabhata, Sutra Sthana; Bheshajavacharaniya Adhyaya: Chapter 23, Verse 10. Delhi: Chaukhamba Sanskrit Pratishthan, 2015; 426-427.</ref><br/>In hot season, the body remains weak due to the effect of season (aadana kala), dry and hot wind, and excessive perspiration. This increases the fluidity of the dosha, and they penetrate more in the channels of the body. In these conditions, even if an aushadha of slightly hot potency is administered, it also produces excessive heat in the body due to hot temperature. Thus more effect of aushadha is observed even at lower doses of aushadha in hot season.<ref>Tripathi R.D., (1 st ed.). Commentary Saroj on Astanga Sangrah of Vridhavagabhata, Sutra Sthana; Bheshajavacharaniya Adhyaya: Chapter 23, Verse 11. Delhi: Chaukhamba Sanskrit Pratishthan, 2015; 427.</ref></div>
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