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After gaining the knowledge about the classification of diseases, the routes of manifestation and the nomenclature of diseases must be known, hence the routes of disease manifestation are described.
 
After gaining the knowledge about the classification of diseases, the routes of manifestation and the nomenclature of diseases must be known, hence the routes of disease manifestation are described.
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==== Three rogamargas (routes for disease manifestation) ====
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==== Three ''rogamargas'' (routes for disease manifestation) ====
 
 
In the process of sthana samshraya doshas after circulating all over the body, get accumulated in dushyas in particular strotas, next step is dosha- dusha sammurchhana, doshas vitiate the dushyas and first produce premonitory symptoms. The manifestation of symptoms of disease follows a route depending upon the movement of vitiated doshas inside the body and the involvement of strotas. Ayurveda considers three rogamargas or rogayatana/ routes for manifestation of diseases - shakha (bahya rogamarga: twachha and raktadi dhatus - periphery), marma asthisandhi (madhyam rogamarga: Vital organs, bones, joints & ligaments-tendons), kostha (abhyantara rogamarga: Gastrointestinal tract & central part of body). The diseases manifesting in particular rogamarga is also described.  
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In the process of ''sthana samshraya doshas'' after circulating all over the body, get accumulated in ''dushyas'' in particular ''strotas'', next step is ''dosha- dushya sammurchhana'', ''doshas'' vitiate the ''dushyas'' and first produce premonitory symptoms. The manifestation of symptoms of disease follows a route depending upon the movement of vitiated ''doshas'' inside the body and the involvement of ''strotas''. Ayurveda considers three ''rogamargas'' or ''rogayatana''/ routes for manifestation of diseases - ''shakha'' (''bahya rogamarga'': ''twachha'' and ''raktadi dhatus'' - periphery), ''marma asthisandhi'' (''madhyam rogamarga'': Vital organs, bones, joints & ligaments-tendons), ''kostha'' (''abhyantara rogamarga'': Gastrointestinal tract and central part of body). The diseases manifesting in particular ''rogamarga'' is also described.  
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Charkapani has commented that three rogamargas [15] include marma asthi sandhi as one route, shakha nomenculature is given for the practical purpose, as the dhatus here are like the branches of tree. Twachha denotes here the ‘rasa dhatu’ which is present in twachha(skin), directly it is not stated as “rasa”, as it is different from the ‘rasa’ dhatu present in hridaya (heart). The vitiation of rasa residing in hridaya is considered in ‘kostha’, also the vitiated rakta dhatu which is present in yakruta (liver) and pleeha (spleen). Ama sthana – amasaya (stomach), agni sthana (site of agni- pancreas), site of digested food –pakwashaya (terminal ileum and large intestine), mutrashaya (urinary bladder), rudhir sthana (yakruta-liver, pleeha- spleen), hridaya (heart), unduka (caecum), phuphhupus (lungs) are considered as part of kostha (Su.Chi.2). Asthi sandhi stands for the joints and the tendons and ligaments. The description of rogamarga helps in knowing the prognosis of diseases.  
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Charkapani has commented that three ''rogamargas'' [15] include ''marma asthi sandhi'' as one route, ''shakha'' nomenculature is given for the practical purpose, as the ''dhatus'' here are like the branches of tree. ''Twachha'' denotes here the ''rasa dhatu'' which is present in ''twachha''(skin), directly it is not stated as ''rasa'', as it is different from the ''rasa dhatu'' present in ''hridaya'' (heart). The vitiation of ''rasa'' residing in ''hridaya'' is considered in ''kostha'', also the vitiated ''rakta dhatu'' which is present in ''yakrita'' (liver) and ''pleeha'' (spleen). ''Ama sthana – amashaya'' (stomach), ''agni sthana'' (site of ''agni''- pancreas), site of digested food –''pakwashaya'' (terminal ileum and large intestine), ''mutrashaya'' (urinary bladder), ''rudhir sthana'' (''yakrita''-liver, ''pleeha''- spleen), ''hridaya'' (heart), ''unduka'' (caecum), ''phuphhupus'' (lungs) are considered as part of ''kostha'' (Su.Chi.2). ''Asthi sandhi'' stands for the joints and the tendons and ligaments. The description of ''rogamarga'' helps in knowing the prognosis of diseases.  
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[[Sutra Sthana]] Chapter 28 has explained the causes responsible for the movement of doshas from kostha to shakha. Due to strenuous exercise, hyperfunctioning of agni (digestive power), non-observance of wholesome regimen and the pressure of vitiated vata dosha causes movement of doshas from kostha to shakhas, they remain there till further aggravation. If already in stage of aggravation, then only they produce disease (Ch. Su.28/31-32). The factors responsible for the movement of doshas from shakha to kostha are also mentioned, aggravation of doshas, increase in their fluidity, paka (suppuration), by the removal of the obstruction at the entrance of the channels and reduced pressure of vata dosha. This knowledge helps in planning the treatment for the vitiated doshas accumulated in particular rogamarga.
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[[Sutra Sthana]] Chapter 28 has explained the causes responsible for the movement of ''doshas'' from ''kostha'' to ''shakha''. Due to strenuous exercise, hyperfunctioning of ''agni'' (digestive power), non-observance of wholesome regimen and the pressure of vitiated ''vata'' ''dosha'' causes movement of ''doshas'' from ''kostha'' to ''shakhas'', they remain there till further aggravation. If already in stage of aggravation, then only they produce disease (Ch. Su.28/31-32). The factors responsible for the movement of ''doshas'' from ''shakha'' to ''kostha'' are also mentioned, aggravation of ''doshas'', increase in their fluidity, ''paka'' (suppuration), by the removal of the obstruction at the entrance of the channels and reduced pressure of ''vata dosha''. This knowledge helps in planning the treatment for the vitiated ''doshas'' accumulated in particular ''rogamarga''.
    
In contemporary medical science the symptoms of the diseases are mentioned according to involvement of the systems. For eg: diseases produced in respiratory tract are bronchitis, pneumonia, bronchiectasis, bronchial asthma etc. the presenting features of which are cough, expectoration, chest pain, dyspnoea etc.
 
In contemporary medical science the symptoms of the diseases are mentioned according to involvement of the systems. For eg: diseases produced in respiratory tract are bronchitis, pneumonia, bronchiectasis, bronchial asthma etc. the presenting features of which are cough, expectoration, chest pain, dyspnoea etc.

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