Changes

==Current researches==

==Current researches==

   

   

Rasayana effects of therapies or drugs are assessed usually by its capacity to manage oxidative stress, which leads to cell and tissue damage. Free radicals and reactive oxygen species (ROS) are formed as a result of metabolism. They are considered as highly reactive. Excessive accumulation of these will initiates cellular damage and may cause diseases. The anti oxidants scavenge these free radicals and ROS, and make them harmless.<ref name=Devangi>Devangi N Oza, Ila Tanna, B Ravishankar, HM Chandola. Evaluation of Bhringarajadi Ghrita Rasayana in Premature Ageing. Ayu. 2009 Apr;30(2):109-20.</ref>  Malondialdehyde (MDA) is also a highly reactive compound and is considered as a marker for oxidative stress. These free radicals are neutralized normally by the antioxidant enzymes like Super oxide dismutase (SOD). In a study on 30 healthy individuals, Withania somnifera (ashwaganda) and Tinospora cordifolia (guduchi) showed significant increase in the levels of SOD and decrease in MDA levels.<ref>Devangi N Oza, Ila Tanna, B Ravishankar, HM Chandola. Evaluation of Bhringarajadi Ghrita Rasayana in Premature Ageing. Ayu. 2009 Apr;30(2):109-20.</ref>

Rasayana effects of therapies or drugs are assessed usually by its capacity to manage oxidative stress, which leads to cell and tissue damage. Free radicals and reactive oxygen species (ROS) are formed as a result of metabolism. They are considered as highly reactive. Excessive accumulation of these will initiates cellular damage and may cause diseases. The anti oxidants scavenge these free radicals and ROS, and make them harmless.<ref name=Devangi>Devangi N Oza, Ila Tanna, B Ravishankar, HM Chandola. Evaluation of Bhringarajadi Ghrita Rasayana in Premature Ageing. Ayu. 2009 Apr;30(2):109-20.</ref>  Malondialdehyde (MDA) is also a highly reactive compound and is considered as a marker for oxidative stress. These free radicals are neutralized normally by the antioxidant enzymes like Super oxide dismutase (SOD). In a study on 30 healthy individuals, Withania somnifera (ashwaganda) and Tinospora cordifolia (guduchi) showed significant increase in the levels of SOD and decrease in MDA levels.<ref>Kuchewar VV, Borkar MA, Nisargandha MA. Evaluation of antioxidant potential of Rasayana drugs in healthy human volunteers. Ayu. 2014 Jan;35(1):46-9. doi: 10.4103/0974-8520.141919. PMID: 25364199; PMCID: PMC4213967.</ref>

Adaptogenic and anti stress properties of Ashwaganda is reported in number of studies. It is found to be effective in preventing the stress induced ulcers in GIT, increases the body weight and reduce leucocytosis. It has anti tumor activity as it shows long term growth inhibition on Chinese Hamster Ovary (CHO) cells carcinoma. In neurodegenerative diseases, it shows preventive and curative effect. It removes or restores the neuritic atrophy and synaptic loss and might be having GABA mimetic activity. Anxiolytic and antidepressant effects of Ashwaganda are also reported.<ref>Singh N, Bhalla M, de Jager P, Gilca M. An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda. Afr J Tradit Complement Altern Med. 2011;8(5 Suppl):208-13. doi: 10.4314/ajtcam.v8i5S.9. Epub 2011 Jul 3. PMID: 22754076; PMCID: PMC3252722.</ref>

Adaptogenic and anti stress properties of Ashwaganda is reported in number of studies. It is found to be effective in preventing the stress induced ulcers in GIT, increases the body weight and reduce leucocytosis. It has anti tumor activity as it shows long term growth inhibition on Chinese Hamster Ovary (CHO) cells carcinoma. In neurodegenerative diseases, it shows preventive and curative effect. It removes or restores the neuritic atrophy and synaptic loss and might be having GABA mimetic activity. Anxiolytic and antidepressant effects of Ashwaganda are also reported.<ref>Singh N, Bhalla M, de Jager P, Gilca M. An overview on ashwagandha: a Rasayana (rejuvenator) of Ayurveda. Afr J Tradit Complement Altern Med. 2011;8(5 Suppl):208-13. doi: 10.4314/ajtcam.v8i5S.9. Epub 2011 Jul 3. PMID: 22754076; PMCID: PMC3252722.</ref>