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[[Agni]] is the physiological entity responsible for the status of [[dosha]]. [Cha.Sa.[[Chikitsa Sthana]]5/136] The dhatvagni being a part of this [[agni]] component, is thus equally responsible in the maintenance of health and even in the affliction of diseases. The dhatvagni is a determinant of the production and functions of [[dhatu]]. Hence its proper functioning is of utmost importance in health. Imbalance can lead to disease manifestation. For instance, in condition like [[raktapitta]], the excessive [[pitta]] is responsible for the overstimulation of [[agni]] and dhatvagni, leading to the depletion of quality of [[rakta dhatu]] and liquidity (dravana).[Cha.Sa.[[Chikitsa Sthana]] 4/8] Here the dhatvagni is overstimulated, leading to an imbalance in the tissue metabolism. Also, in conditions like obesity (sthoulya), the [[meda dhatu]] metabolism weakens, leading to excessive [[meda]] (fat deposition). Undernourishment of the remaining [[dhatu]] depicts the slow metabolism of meda (meda-dhatvagnimandya) in the body. [Cha.Sa.[[Sutra Sthana]] 21/5-8]
[[Agni]] is the physiological entity responsible for the status of [[dosha]]. [Cha.Sa.[[Chikitsa Sthana]]5/136] The dhatvagni being a part of this [[agni]] component, is thus equally responsible in the maintenance of health and even in the affliction of diseases. The dhatvagni is a determinant of the production and functions of [[dhatu]]. Hence its proper functioning is of utmost importance in health. Imbalance can lead to disease manifestation. For instance, in condition like [[raktapitta]], the excessive [[pitta]] is responsible for the overstimulation of [[agni]] and dhatvagni, leading to the depletion of quality of [[rakta dhatu]] and liquidity (dravana).[Cha.Sa.[[Chikitsa Sthana]] 4/8] Here the dhatvagni is overstimulated, leading to an imbalance in the tissue metabolism. Also, in conditions like obesity (sthoulya), the [[meda dhatu]] metabolism weakens, leading to excessive [[meda]] (fat deposition). Undernourishment of the remaining [[dhatu]] depicts the slow metabolism of meda (meda-dhatvagnimandya) in the body. [Cha.Sa.[[Sutra Sthana]] 21/5-8]
In the disease [[rajayakshma]], depletion of [[dhatu]] is observed. Dhatvagni plays a pivotal role in the pathological process.[Cha.Sa.[[Chikitsa Sthana]] 8/39-40] The text mentions the term' ushma' in various instances while explaining the metabolism and formation of different [[dhatu]] ([[rakta dhatu]], [[mamsa dhatu]], [[asthi dhatu]]). [Cha.Sa.[[Chikitsa Sthana]] 15/28-31] This concept is also applicable in the pathogenesis of [[pandu]] roga, where the nourishment of [[dhatu]] is hampered leading to laxity and heaviness of [[dhatu]] (dhatushaithilya and dhatugaurava). The quality of the rasa-raktadi dhatu is hampered to a great extent in this condition.[Cha.Sa.[[Chikitsa Sthana]] 16/4-6] The dhatugata disorders are result of dysfunctions of dhatvagni. Dhatvagni is responsible for breakdown (bhinnasanghata), oxidation (dahana) leading to heat or energy generation (tapana).
In the disease [[rajayakshma]], depletion of [[dhatu]] is observed. Dhatvagni plays a pivotal role in the pathological process.[Cha.Sa.[[Chikitsa Sthana]] 8/39-40] The text mentions the term' ushma' in various instances while explaining the metabolism and formation of different [[dhatu]] ([[rakta dhatu]], [[mamsa dhatu]], [[asthi dhatu]]). [Cha.Sa.[[Chikitsa Sthana]] 15/28-31] This concept is also applicable in the pathogenesis of [[pandu]] roga, where the nourishment of [[dhatu]] is hampered leading to laxity and heaviness of [[dhatu]] (dhatushaithilya and dhatugaurava). The quality of the rasa-raktadi dhatu is hampered to a great extent in this condition.[Cha.Sa.[[Chikitsa Sthana]] 16/4-6] The dhatugata disorders are result of dysfunctions of dhatvagni. Dhatvagni is responsible for breakdown (bhinnasanghata), oxidation (dahana) leading to heat or energy generation (tapana).
==Recent researches on dhatvagni==
# A research work on the concept of dhatwagnipaka in an Ayurvedic perspective showed that prasadpaka can be compared with anabolic pathways and kittapaka with catabolic pathways.<ref>Vani G, Prasad JSRA. CONCEPT OF DHATVAGNIPAKA IN AYURVEDIC PERSPECTIVE IN COMPARISON WITH TISSUE METABOLISM. Int J Res Ayurveda Pharm. 2016 May 5;7(2):92–7.</ref>
#In the research on role of dhatwagni in carcinogenesis, dhatvagni is related with gene mutation and disequilibrium (vishamaavastha) of [[agni]] leading to manifestation of cancer condition.<ref>Rao SD. DHATWAGNI VYAPARA IN CARCINOGENESIS. Anc Sci Life. 1994;14(1–2):61–7.</ref> The study further states that disequilibrium of [[agni]] causes improper digestion and metabolism leading to decreased or increased or irregular formation of tissues. This is observed in carcinogenesis where intermediate by-products are formed in place of normal protein. The state of irregular dhatvagni is the root cause of tumor.
#In the work on location of physiological activities of dhatwagni and bhautikagni the physiological functioning of dhatvagni is described along with the pathologies in the respective [[dhatu]] due to the malfunctioning of dhatvagni.<ref>Kalpana D. Sathe.2016, Location of Physiological Activities of Dhatwagni And Bhautikagni. Int J Recent Sci Res. 7(2), pp. 9133-9136.</ref> This study concludes that the location of dhatvagni is in the respective tissue of particular [[srotas]] (transportation and transformation system) and cellular level. Secondly, the dhatvagni activity and bhutagni activity can be correlated with catalyst of dhatusnehaparampara and dhatukshalan by bala production by bhautikagnipaka respectively.
#Dhatvagni is considered in the synthesis of new tissue and yielding of energy for the functioning of existent tissue.<ref>A Brief Mention of Agni In Ayurveda, GJRA - Global Journal For Research Analysis(GJRA), GJRA | World Wide Journals [Internet]. [cited 2022 Jul 8]. Available from: https://www.worldwidejournals.com/global-journal-for-research-analysis-GJRA/article/a-brief-mention-of-agni-in-ayurveda/MTEwOTg=/?is=1&b1=61&k=16</ref> Bhutagni acts on respective [[mahabhuta]] portion and dhatvagni acts on respective [[dhatu]]s for nutritional strength, complexion, and happy life.
#A study of dhatvagni with special reference to hypothyroidism depicted that abnormality at the level of [[meda dhatu]] (medodhatvagni vikriti) may be the cause of endocrinal disturbance related to thyroid gland functions. Secondly the excessive illumination of dhatwagni may cause rise in anabolism and catabolism.<ref>Sharma DV, Sharir MDK. STUDY OF DHATWAGNI VIKRITI W.S.R. TO HYPOTHYROIDISM. World Journal of Pharmaceutical Research. 10(5):10.</ref> Another study showed that the the clinical features of low dhatvagni functions (dhatvagnimandya) like slower metabolism (agninasha), pallor (pandutwam), oligomenorrhoea (artavanasha), cold intolerance (sheetaasatmya) etc. can be correlated with symptoms of Hypothyroidism.<ref>??</ref>
#Selective production and transformation of [[dhatu]] is explained. Each dhatvagni synthesize and transform the constituents suitable to its particular [[dhatu]] as a part of selective action.<ref>Agrawal AK, Yadav CR, Meena MS. Physiological aspects of Agni. Ayu. 2010;31(3):395–8.</ref>
7. The inter-relationship between jatharagniand dhatvagniin the manifestation of different diseasesis established. Agniare connected with each other and due to this relationship, vitiation of jatharagniresults in vitiation of all the other agni.
8. The inter relationship between the occurrence of ama,dhatvagnimandyaand their role in manifestation of diseases is observed invarious diseases. In metabolic disorders like amavata, medoroga, prameha, sthaulya, etc. the role of ama and dhatvagniis very important.
9. The role of dhatvagnimandyain the occurrence of various upadhatujanyavikara is discussed. Any kind of vitiation to the status of agni or dhatvagni, srotasand vataleads to manifestation of upadhatupradoshajavikara.
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