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Metabolic process and thermoregulatory center situated in hypothalamus play key role to generate and maintain body temperature respectively. Reduced temperature shows slow metabolic process and gradually it ceases completely, causing death.  
 
Metabolic process and thermoregulatory center situated in hypothalamus play key role to generate and maintain body temperature respectively. Reduced temperature shows slow metabolic process and gradually it ceases completely, causing death.  
 
With the help of healthy digestive power and proper metabolic activity; food nourishes the body and provide macro and micronutrients to the body. [3]
 
With the help of healthy digestive power and proper metabolic activity; food nourishes the body and provide macro and micronutrients to the body. [3]
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In any manner, hampered blood or oxygen supply to the brain leads to lack of concentration, weakness of mental functions or agitation. Deposition of any toxic substance or progressive degenerative changes of mind also leads to such symptoms.
 
In any manner, hampered blood or oxygen supply to the brain leads to lack of concentration, weakness of mental functions or agitation. Deposition of any toxic substance or progressive degenerative changes of mind also leads to such symptoms.
 
Ageing and death are considered as natural process with passage of time.[4] With declining phase of life, ageing symptoms start to appear, as new cell production is almost stops and older cell destruction continues. With the passage of senescence; weakness, decreasing Appetite, muscular wasting, decreased fluid intake, neurological dysfunctions, decreasing level of consciousness etc. are common symptoms manifest and gradually leads to cessation of life. [5]
 
Ageing and death are considered as natural process with passage of time.[4] With declining phase of life, ageing symptoms start to appear, as new cell production is almost stops and older cell destruction continues. With the passage of senescence; weakness, decreasing Appetite, muscular wasting, decreased fluid intake, neurological dysfunctions, decreasing level of consciousness etc. are common symptoms manifest and gradually leads to cessation of life. [5]
Every individual has good appetite and capability of digesting foods he regularly ingests. Ksheerada(only on milk) ksheeraannaa (milk and rice products) Annada (staple foods), are three basic stages of life. During ageing process, gradual reduction in both qualitative consumption and digestive abilities are observed. This inturn influences the individual’s physical and mental wellbeing leading to reduction in life span ending in death.[3]
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As per the principle of “YatBrahmande Tat Pinde”, whatever is there in the universe, is there in the human body. Hence there should be some connections between human body and the universe. When the soul is preparing for detachment from the body to start its journey to other world, there should be some indications from the universe as indicator of impending death. As per Indian tradition, offerings of food to birds specially to Crow and non-acceptance of offering by crow may indicate the preparation of soul for detachment from living body. Inability to see Arundhati in sky is another indication of the same. [4 – 5]
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Every individual has good appetite and capability of digesting foods he regularly ingests. ''Ksheerada''(only on milk), ''ksheera-anna''(milk and rice products), ''annada'' (staple foods), are three basic stages of life. During ageing process, gradual reduction in both qualitative consumption and digestive abilities are observed. This in turn influences the individual’s physical and mental wellbeing leading to reduction in life span ending in death.[3]
Acute loss or gain of luster or body weight can be the result of carcinogenic condition or severe catabolic changes taking place in the body that can be fatal for the person. [6]
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As per the principle of ''Yatha Brahmande Tatha Pinde'', whatever is there in the universe, is there in the human body. Hence there should be some connections between human body and the universe. When the soul is preparing for detachment from the body to start its journey to other world, there should be some indications from the universe as indicator of impending death. As per Indian tradition, offerings of food to birds specially to crow and non-acceptance of offering by crow may indicate the preparation of soul for detachment from living body. Inability to see ''Arundhati'' in sky is another indication of the same. [4 – 5]
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Acute loss or gain of luster or body weight can be the result of carcinogenic condition or severe catabolic changes taking place in the body that can be fatal for the person. [6]
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Brain regulates multiple functions related to sensory, motor and autonomous nervous system like emotions, intellect and many other activities. Amygdala, and physiological functioning of limbic system of brain, are responsible for proper emotions and its expression. If these are deviated grossly, it shows involvement of higher center in pathogenesis and poor prognosis.
 
Brain regulates multiple functions related to sensory, motor and autonomous nervous system like emotions, intellect and many other activities. Amygdala, and physiological functioning of limbic system of brain, are responsible for proper emotions and its expression. If these are deviated grossly, it shows involvement of higher center in pathogenesis and poor prognosis.
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Gradual cessation of the functions is a clear indication of either degenerative changes or space occupying lesion (SOL) in the specific area. Acute toxicity of brain also leads to acute degeneration of brain cells or infarction that leads to hampering of function. [7]
 
Gradual cessation of the functions is a clear indication of either degenerative changes or space occupying lesion (SOL) in the specific area. Acute toxicity of brain also leads to acute degeneration of brain cells or infarction that leads to hampering of function. [7]
Sudden appearance of cresent shaped streaks or blood vessel network on forehead may relate with Amyloidosis. It is a rare disease that occurs when a protein (albumoid) substance gets deposited in person’s organ. This abnormal protein is usually produced in bone marrow and can be deposited in any tissue or organ. The prognosis is poor. [8-9][6]   
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Sudden appearance of crescent shaped streaks or blood vessel network on forehead may relate with Amyloidosis. It is a rare disease that occurs when a protein (albumoid) substance gets deposited in person’s organ. This abnormal protein is usually produced in bone marrow and can be deposited in any tissue or organ. The prognosis is poor. [8-9][6]   
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If person having combination of dual type of activity of mind i.e. exaggerated (in form of tremor), and diminished activity (in form of stupor), simultaneously; is supposed to die within a month. These dual types of signs may indicate increased intracranial pressure (ICP) due to localized mass like hematoma, neoplasm, abscess, edema, infarction, obstruction in CSF circulation, diffuse brain edema (like encephalitis, meningitis, or diffuse head injury), thrombosis, or idiopathic intracranial hypertension.  
 
If person having combination of dual type of activity of mind i.e. exaggerated (in form of tremor), and diminished activity (in form of stupor), simultaneously; is supposed to die within a month. These dual types of signs may indicate increased intracranial pressure (ICP) due to localized mass like hematoma, neoplasm, abscess, edema, infarction, obstruction in CSF circulation, diffuse brain edema (like encephalitis, meningitis, or diffuse head injury), thrombosis, or idiopathic intracranial hypertension.  
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Symptoms of raised ICP are altered mental state, lethargy, irritability, slow decision making and abnormal social behaviour. Ultimate result of the patho-physiology of such condition is stupor, coma and death. Rapidly rising ICP leads to syncope, seizures. These neurologic changes seen in increased ICP are mostly due to hypoxia and hyper apnoea. [10]
 
Symptoms of raised ICP are altered mental state, lethargy, irritability, slow decision making and abnormal social behaviour. Ultimate result of the patho-physiology of such condition is stupor, coma and death. Rapidly rising ICP leads to syncope, seizures. These neurologic changes seen in increased ICP are mostly due to hypoxia and hyper apnoea. [10]
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If fecal matter or other excreta are mixed with Ama, it sinks straight in water due to its heaviness. Same concept is applied to other body discharge or Dhatus too.  Fecal matter is the end product of digestion. Hence, if it sinks in water it shows incomplete or improper digestion of food. Shukra is the last Dhatu and hence all Dhatvagni contribute (directly or indirectly) in its formation. To sink Shukra in water is indicative that the Dhatu is in Sama stage. To get dipped all the three i.e. feces, urine and semen shows impairment of Jatharagni along with Dhatvagni functions leading to qualitative mal-formation of all Dhatus. Such situation has been considered as fatal. [11]
 
If fecal matter or other excreta are mixed with Ama, it sinks straight in water due to its heaviness. Same concept is applied to other body discharge or Dhatus too.  Fecal matter is the end product of digestion. Hence, if it sinks in water it shows incomplete or improper digestion of food. Shukra is the last Dhatu and hence all Dhatvagni contribute (directly or indirectly) in its formation. To sink Shukra in water is indicative that the Dhatu is in Sama stage. To get dipped all the three i.e. feces, urine and semen shows impairment of Jatharagni along with Dhatvagni functions leading to qualitative mal-formation of all Dhatus. Such situation has been considered as fatal. [11]
 
Muscular wasting of hands and feet is a type of neurogenic muscular atrophy with poor prognosis.
 
Muscular wasting of hands and feet is a type of neurogenic muscular atrophy with poor prognosis.
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Swelling over both extremities along with face is an indication of damage of two vital organ simultaneously  i.e. heart and kidney and hence survival of patient is difficult.[12]
 
Swelling over both extremities along with face is an indication of damage of two vital organ simultaneously  i.e. heart and kidney and hence survival of patient is difficult.[12]
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Appearance of blue lines occurs in various conditions. This may be indication of venous congestion due to heart, lungs and liver diseases, requiring attention while scaling the span of life. [13]
 
Appearance of blue lines occurs in various conditions. This may be indication of venous congestion due to heart, lungs and liver diseases, requiring attention while scaling the span of life. [13]
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Immediate disappearance of manifested small pox subsequently develops acute toxemia and hence leads to death. [14]
 
Immediate disappearance of manifested small pox subsequently develops acute toxemia and hence leads to death. [14]
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Combined manifestation of stiff neck along with inflamed throat & scrotum and swollen tongue is the condition of tertiary stage of syphilis when the person develops syphilitic meningitis (complication of untreated syphilis), is a life threatening condition.  [15]
 
Combined manifestation of stiff neck along with inflamed throat & scrotum and swollen tongue is the condition of tertiary stage of syphilis when the person develops syphilitic meningitis (complication of untreated syphilis), is a life threatening condition.  [15]
 
Visual (or even other sensorial) hallucinations are often part of the dying experience. Person may unknowingly involve in such activities with such illusions. This is the phase when the soul is getting ready to detach from the body and to travel for another world. The dying may turn their focus to “another world”, and thus may see (or feel other sensorial hallucination of) some unusual things, he may see or talk to such people who are already died. [18-19]
 
Visual (or even other sensorial) hallucinations are often part of the dying experience. Person may unknowingly involve in such activities with such illusions. This is the phase when the soul is getting ready to detach from the body and to travel for another world. The dying may turn their focus to “another world”, and thus may see (or feel other sensorial hallucination of) some unusual things, he may see or talk to such people who are already died. [18-19]
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Various kinds of hallucinations are indications of altered psychological state of dying person, and to have laughter without any specific cause is also result of such hallucinations. To lick own lips is the sign of dehydration and coldness of breath and extremity are the indication of almost reducing function of heart and hence, stoppage of blood flow to concerned area. [20] Delusions along with altered sensorial organ is the sign of death. [21]
 
Various kinds of hallucinations are indications of altered psychological state of dying person, and to have laughter without any specific cause is also result of such hallucinations. To lick own lips is the sign of dehydration and coldness of breath and extremity are the indication of almost reducing function of heart and hence, stoppage of blood flow to concerned area. [20] Delusions along with altered sensorial organ is the sign of death. [21]
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Days or hours before death, the dying person becomes less and less responsive to voice and touch and may not awaken. (Sometimes, quite unexpectedly, the person may appear well and even look as if he/she is going to recover. The person may be alert and talkative. But it does not mean that he is getting well; of course the time may be used as a “window of opportunity” to say what you need to say and have closure). [8] These all of sudden recovery changes are also signs of near death. [25]
 
Days or hours before death, the dying person becomes less and less responsive to voice and touch and may not awaken. (Sometimes, quite unexpectedly, the person may appear well and even look as if he/she is going to recover. The person may be alert and talkative. But it does not mean that he is getting well; of course the time may be used as a “window of opportunity” to say what you need to say and have closure). [8] These all of sudden recovery changes are also signs of near death. [25]
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As per ancient classical texts, life span of everyone is fixed & pre decided, no one can add years to the life only quality of life can be improved with medications. Same thing is meant here that if death is the destiny of patient; desirable quality of medicine, human resource and all other things cannot survive the person.[27]
 
As per ancient classical texts, life span of everyone is fixed & pre decided, no one can add years to the life only quality of life can be improved with medications. Same thing is meant here that if death is the destiny of patient; desirable quality of medicine, human resource and all other things cannot survive the person.[27]
  

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