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== Probable mode of action ==
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The main constituent of this madhutailika basti is honey (madhu) and sesame oil (tila taila). Madhu is yogavahi (drug carrier) in nature due to which it spreads to minute channels (sukshma srotasa) and increases potency of basti. Tila taila is snigdha (unctuous), madhura (sweet) and ushna (hot) in nature. It reduces laghu (light to digest) and ruksha (dry) properties of vata.  Saindhava has laghu, snigdha guna. It reaches micro channels and causes liquefaction of dosha. Erandamula is vata-kaphaghna in nature. The most of the contents of this basti are vata-kaphaghna in nature.
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Madhumeha is one of the kapha and kleda dominant disease  with vitiation of mamsa, meda, rasa, and ojas. Madhutailika basti purifies the vitiated components with the help of honey and salt. It breaks the bondage of dosha (doshasanghata) and purifies channels (srotoshodhana). It enhances strength (bala) and digestion (agni) leading to proper nourishment of dhatu. In medoroga, functions of agni are disturbed leading to improper formation of dhatu and only meda dhatu is excessively formed. Madhutailika basti owing to its vata-kaphaghna nature helps in medoroga as well as it cleans the channels. Madhu and tila taila are medohara in nature. Hence they help in breaking the pathogenesis. 
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Also, basti improves functioning of agni and stimulates sequential formation of good quality dhatu.. In Udavarta, there is reverse movement of vata, basti is the best treatment to provide natural direction to vata dosha. This basti contains decoction of castor plant (Erandamula Kwatha), which is the best for pacifying vata. As this basti reaches microchannels and does liquefaction of doshas, it produces balya , varnya , deepana and brimhana effects.
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{| class="wikitable"
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|+ Table 2: Research works with their outcome on Madhutailika Basti:
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! Sr no
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! Title
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! Authors
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! Research Place and year
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! Conclusion
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|-
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| 1
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| Clinical study to evaluate the efficacy of Madhutailika Basti in the management of Madhumeha w.s.r. To Diabetes Mellitus. <ref>Dr. Mridula Pathak, & Dr. Ashish Mhatre. (2018). Clinical study to evaluate the efficacy of Madhutailika Basti in the management of Madhumeha w.s.r. To Diabetes Mellitus. Journal of Ayurveda and Integrated Medical Sciences, 3(05), 21-26. Retrieved from https://www.jaims.in/jaims/article/view/488 </ref>
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| Dr. Mridula Pathak <br/>Dr. Ashish Mhatre
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| Dept of Kayachikitsa, OPD/IPD of D.Y.Patil school of Ayurveda , 2018.
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| Madhutailka basti was given for 8 days and it is found effective clinically as well as statistically  in  the  treatment  of Diabetes  Mellitus. Also, it gives significant results in blood sugar level and HbA1C which is used for diagnosis of DM.
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|-
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| 2
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| Role of Madhutailika Basti in infertility w.s.r. to anovulatory factor. <ref>Dhiman, Kamini & Pandya, Shachi & Dei, Laxmipriya. (2014). Role of madhutailika basti in infertility w.s.r. to anovulatory factor. Journal of Ayurveda & Holistic Medicine. 2. 19 - 26.</ref>
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| Dr.Kamini Dhiman, <br/>Dr. Shachi Pandya,<br/>Dr. L. P. Dei,<br/>Dr.Anup Thakar,<br/>Dr.K.S. Dhiman
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| OPD/IPD of S.R.P.T. Dept, I.P.G.T & R.A Jamnagar,2014.
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| The effect of basti was encouraging in reference to ovulation.
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|-
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| 3
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| Study of effect of Madhutailika Basti (rejuvenating enema containing honey and seasame oil) on fatigue index in premature ageing. <ref>Chavan S, Vedpathak S, Indapurkar K, Ghate U. Study of effect of madhutailika basti (rejuvenating enema containing honey and seasame oil) on fatigue index in premature ageing. 2018 Apr 25;7.</ref>
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| Dr.Santosh Chavan,<br/>Dr. Surendra M. Vedpathak,<br/>Dr.Kavita Indapurkar <br/>Dr. Umesh Shivajirao Ghate
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| O.P.D of B.V.M.F.S Bharti Ayurveda Hospital , Katraj,2018.
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| Madhutailika Basti shows positive effect on physical fitness (fatigue index) in premature aging patient.
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|-
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| 4
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| Pharmaceutical evaluation of Madhutailika basti formulation prepared by Classical and Modified Methods. <ref>Dr. Shruthi C.S., Prabhakara Upadhyaya Renjal, & Sujatha K. (2017). Pharmaceutical evaluation of Madhutailika Basti formulation prepared by Classical and Modified Methods. Journal of Ayurveda and Integrated Medical Sciences, 2(01), 85-91. Retrieved from https://www.jaims.in/jaims/article/view/101</ref>
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| Dr. Shruthi C.S.<br/>Prabhakara Upadhyaya Renjal Sujatha K.
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| Dept of R.S.B.K, S.D.M College of Ayurveda, Udupi,2017.
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| Samples prepared with Churner, those from mixer and edge runner mill can be considered as inferior respectively.
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|-
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| 5
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| A comparative clinical study of madhutailik kal-basti and udvartana with madhutailik kala basti in medoroga with special reference to obesity. <ref>Tomar D.P. A comparative clinical study of madhutailik kal-basti and udvartana with madhutailik kala basti in medoroga with special reference to obesity. 2015;10.</ref>
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| Dr.Prajkta Tomar
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| Panchakarma/ Kayachikitsa OPD of attached hospital with Sumatibai Shah Ayurveda Mahavidyalaya, Hadapsar, Pune, 2015.
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| In Group-A (madhultailik basti), the mean reduction in Sharir bhar (Weight) observed among patients was 3 kg. Body Mass Index was reduced by 1.3 kg/m<sup>2</sup> . While in Group-B, the mean reduction of weight was 4.20 kg and body mass index was reduced by 1.4 kg/m<sup>2</sup>.
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|-
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| 6
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| Study of Preparation and Standardization of 'Maadhutailika Basti' with special reference to Emulsion Stability. <ref>Savrikar SS, Lagad CE. Study of Preparation and Standardization of 'Maadhutailika Basti' with special reference to Emulsion Stability. Ayu. 2010 Jan;31(1):1-6. Doi: 10.4103/0974-8520.68190. PMID: 22131675; PMCID: PMC3215309.</ref>
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| S S Savrikar <br/>C E Lagad
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| Dept of R.S.B.K, Govt. Ayurveda College, Nanded,2010.
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| Maadhutailika basti is oil in water emulsion as proved by dilution, conductivity and dye test. The serial order of mixing the ingredients mentioned by classics should be maintained to get a homogenized emulsion.
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|-
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| 7
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| Effect of Madhu tailika basti And Shamana aushadhi In polycycstic ovarian diseases. <ref>M. Reddi, S., V, A., & Mishra, B. (2015). Effect of Madhu Tailika Basti and Shamana aushadhi in poly-cystic ovarian diseases. International Journal of Ayurveda and Pharma Research, 2(7). Retrieved from https://ijapr.in/index.php/ijapr/article/view/192</ref>
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| Shridevi. M. Reddi,<br/>Anupama. V,<br/>Baidyanath Mishra
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| O.P.D/I.P.D of Dept of S.R.P.T of SKAMCH & RC , Vijayanagar , Banglore,2014.
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| The trial drug was found to be highly significant in reliving PCOD.
 
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