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==Preamble of Kalpa Sthana ==
 
==Preamble of Kalpa Sthana ==
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<div style="text-align:justify;">A healthy individual is an asset to any society (and contributes to making a healthy society), while a sick individual will be a liability to his family in particular and the society at large. To keep oneself healthy, [[Ayurveda]] lays down the principles of various lifestyles in terms of daily regimen (''dinacharya''), seasonal regimen (''ritucharya'') and modified lifestyles to cure the diseases. Physical exercise for the preservation of health begins with adapting techniques for purification of the body and the mind along with an intake of ''rasayana'' drugs (rejuvenatives). Accumulated ''malas'' (metabolic waste) at the level of cell, tissue or organ should be expunged out to facilitate the restoration of normal functioning of the body by five purificatory procedures (''shodhana karma'') often referred as [[Panchakarma]], namely ''vamana'' (emesis), ''virechana'' (purgation), ''asthapana basti'' (evacuative enema), ''anuvasana basti'' (restorative enema), and ''shirovirechana'' (errhines) are indicated for healthy as well as diseased persons. If ''malas'' are not taken out of the body, they cause diseases and decay (ageing) of the body. After purification procedures, ''jatharagni'' (gastro-intestinal digestive juices) becomes weak and may not digest the food normally.  For restoration of this function, the food that is easily digestible is introduced and increased gradually over a period of time and this procedure is called ''samsarjana karma''. Details of pharmaceutical process of drugs employed in ''vamana'' and ''virechana'' procedures are given in this section and detailed therapeutic implications of all the ''shodhana'' karma in [[Siddhi Sthana]].  
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<div style="text-align:justify;">A healthy individual is an asset to any society, while a sick individual will be a liability to his family in particular and the society at large. To keep oneself healthy, [[Ayurveda]] lays down the principles of various lifestyles in terms of daily regimen (''dinacharya''), seasonal regimen (''ritucharya'') and modified lifestyles to cure the diseases. Physical exercise for the preservation of health begins with adapting techniques for purification of the body and the mind along with an intake of ''rasayana'' drugs (rejuvenatives). Accumulated ''malas'' (metabolic waste) at the level of cell, tissue or organ should be expunged out to facilitate the restoration of normal functioning of the body by five purificatory procedures (''shodhana karma'') often referred as [[Panchakarma]], namely ''vamana'' (emesis), ''virechana'' (purgation), ''asthapana basti'' (evacuative enema), ''anuvasana basti'' (restorative enema), and ''shirovirechana'' (errhines) are indicated for healthy as well as diseased persons. If ''malas'' are not taken out of the body, they cause diseases and decay (ageing) of the body. After purification procedures, ''jatharagni'' (gastro-intestinal digestive juices) becomes weak and may not digest the food normally.  For restoration of this function, the food that is easily digestible is introduced and increased gradually over a period of time and this procedure is called ''samsarjana karma''. Details of pharmaceutical process of drugs employed in ''vamana'' and ''virechana'' procedures are given in this section and detailed therapeutic implications of all the ''shodhana'' karma in [[Siddhi Sthana]].  
 
''Vamana'' and ''virechana'' therapies should be administered before administering ''basti'' (medicated enema therapy). Therefore, ''vamana'' and ''virechana'' drugs are first described in [[Kalpa Sthana]] before the description of ''basti'' therapy, which is described in detail under [[Siddhi Sthana]]. Generally, purgation therapy is administered only after the administration of emetic therapy and keeping this view the first six chapters are allocated for description of emetic drugs.  
 
''Vamana'' and ''virechana'' therapies should be administered before administering ''basti'' (medicated enema therapy). Therefore, ''vamana'' and ''virechana'' drugs are first described in [[Kalpa Sthana]] before the description of ''basti'' therapy, which is described in detail under [[Siddhi Sthana]]. Generally, purgation therapy is administered only after the administration of emetic therapy and keeping this view the first six chapters are allocated for description of emetic drugs.  
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''Vamanopaga'' drugs (synergistic drugs to ''vamana karma'') like kovidara, karbudara, shanapushpi, pratyakpushpi possess ''agni'' and ''vayu mahabhuta'' dominance can support main ''vamana dravya'' for emetic action, while drugs like draksha, kashmariphala, parushaka, badara, kuvala, peelu, karkandhu are ''prithvi'' and ''ap mahabhuta'' dominant drugs, which can support the main ''virechaka'' drugs for inducing purgative action.
 
''Vamanopaga'' drugs (synergistic drugs to ''vamana karma'') like kovidara, karbudara, shanapushpi, pratyakpushpi possess ''agni'' and ''vayu mahabhuta'' dominance can support main ''vamana dravya'' for emetic action, while drugs like draksha, kashmariphala, parushaka, badara, kuvala, peelu, karkandhu are ''prithvi'' and ''ap mahabhuta'' dominant drugs, which can support the main ''virechaka'' drugs for inducing purgative action.
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To summarize the content of ''Kalpa sthana'' of Charak samhita it appears that the information about most popular emetic and purgative drugs with various dosage forms is furnished. And more research is required to explain modus operandii of emetic and purgative drugs and their therapeutic applicability through evidence based clinical trials.
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To summarize the content of ''Kalpa sthana'' of Charak samhita it appears that the information about most popular emetic and purgative drugs with various dosage forms is furnished. And more research is required to explain modus operandii of emetic and purgative drugs and their therapeutic applicability through evidence based clinical trials which were in vogue during those times.
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=== Important concepts in Kalpa Sthana ===
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* Mode of action of [[Vamana]] and [[Virechana]] (Chapter 1 Verse 5)
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* Factors responsible for potency of drug (Chapter 1 verse 7)
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* Selection of soil and desha classification for collecting good quality medicinal plants (Chapter 1 verse 7-8)
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* Ideal and forbidden areas for collecting medicinal plants (Chapter 1 verse 9)
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* Time period of collection and harvesting herbs (Chapter 1 verse 10)
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* Storage of herbs (Chapter 1 verse 11)
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* Concept of [[Anupana]] (vehicle) (Chapter 1 verse 12)
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* Nasal drug delivery of herbs (Chapter 1 verse 19, Chapter 3 verses 11-12, Chapter 4 verse 10, Chapter 10 verse 17)
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* Concept of ascending dosage schedule (vardhamana matra) (Chapter 3 verse 13)
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* Development of different dosage forms of purgatives according to constitution (Chapter 7 verse 28)
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* Formulation of purgative drugs according to seasons (Chapter 7 verse 56 and 59)
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* Formulation designing according to koshtha(Chapter 10 verse 17) 
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* Principles of indicating nomenclature of formulation (Chapter 12 verse 44)
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* Concept of potentiation of drugs including the theory of antogonism and synergism (Chapter 12 verse 45-48)
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* Categorization or classification of therapeutic response into mild, moderate and severe categories (Chapter 12 verse 50-56)
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* Importance of assessment of roga bala and rogi bala ( severity of disease and strength of patient) for prescribing purification procedures(Chapter 12 verse 60)
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* Management of residual [[dosha]] with food and medicated decoctions after purification therapies (Chapter 12 verse 66)
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* Concept of examination of koshtha (status of gastrointestinal tract) while administering [[vamana]] and [[virechana]] drugs (Chapter 12 verse 67)
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* Concept of sneha and ruksha [[virechana]] (Chapter 12 verse 82-83)
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* Inhibiting factors fro prevention of purgative actions (Chapter 12 verse 80)
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* Concept of posology based upon koshtha(status of gastro intestinal tract), vaya(age) and bala(strength) (Chapter 12 verse 86)
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=== Important areas of research and its clinical applications ===
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* Standardization of procedure of [[vamana]] and [[virechana]] karma
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* Standardization of processes of different dosage forms
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* Studies on procedures and processing of different [[anupana]] like Kwatha, Yavagu, Ksheerapaka, Swarasa, Shashkuli, Shadava, Raga, Shukta, Suramanda, Asava, Sura, Varit, Krishara, Panaka, Sauvira, Tushodaka, Avaleha, Shritapaka, Seedhu, Utkarika
    
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