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The time of administration of medicine is called as ‘Aushadha sevana kala’. The efficacy and safety of medicine vary as per the time of administration. Chrono-pharmacology deals with studies of biological rhythm dependencies of drugs regarding its pharmacological effects and/or pharmacokinetics/dynamics of drugs in both animals and humans.
The time of administration of medicine is called as ‘Aushadha sevana kala’. The efficacy and safety of medicine vary as per the time of administration. Chrono-pharmacology deals with studies of biological rhythm dependencies of drugs regarding its pharmacological effects and/or pharmacokinetics/dynamics of drugs in both animals and humans.
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<br/>In Ayurveda, different times of medicine administration are mentioned for pacification (shamana) therapies. [A. Hr. Sutra Sthana 13]<ref name= Hridaya > Vagbhata. Ashtanga Hridayam. Edited by Harishastri Paradkar Vaidya. 1st ed. Varanasi: Krishnadas Academy;2000.</ref> The principle of circadian rhythm of [[dosha]], their influence on human physiology is considered to achieve highest active potential of a medicine. By applying this principle of chrono-pharmacology, maximum efficacy can be achieved even in smaller doses. Moreover, a single medicine can be used in different disorders as per biological rhythms and states of [[dosha]]. Thus, the requirement of medicine can be reduced to treat multiple disorders. Duration of medical treatment in chronic disorders can also be reduced.
In Ayurveda, different times of medicine administration are mentioned for pacification (shamana) therapies. [A. Hr. Sutra Sthana 13]<ref name= Hridaya > Vagbhata. Ashtanga Hridayam. Edited by Harishastri Paradkar Vaidya. 1st ed. Varanasi: Krishnadas Academy;2000.</ref> The principle of circadian rhythm of [[dosha]], their influence on human physiology is considered to achieve highest active potential of a medicine. By applying this principle of chrono-pharmacology, maximum efficacy can be achieved even in smaller doses. Moreover, a single medicine can be used in different disorders as per biological rhythms and states of [[dosha]]. Thus, the requirement of medicine can be reduced to treat multiple disorders. Duration of medical treatment in chronic disorders can also be reduced.
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It is to be noted that in clinical practice, only gastrointestinal irritation and drug-food interactions are considered while deciding the time of administration. Accordingly the drug is prescribed to take empty stomach or after meals. However, the principles of chronopharmacology in regards to biological rhythm are not followed.
It is to be noted that in clinical practice, only gastrointestinal irritation and drug-food interactions are considered while deciding the time of administration. Accordingly the drug is prescribed to take empty stomach or after meals. However, the principles of chronopharmacology in regards to biological rhythm are not followed.
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The interactions between the external environment and its influence on human biology is less known to contemporary medical science. Change in time, day-night cycle can influence human physiological functions. Accordingly, this may affect absorption and metabolism of a drug. The principles of chrono-pharmacology can provide significant inputs to improve safety and efficacy profiles of drugs. More research studies are needed to establish principles of chrono-pharmacology in current clinical practice. It is still a developing science in today's era. However, ayurvedic rishis have known about it for thousands of years.
The interactions between the external environment and its influence on human biology is less known to contemporary medical science. Change in time, day-night cycle can influence human physiological functions. Accordingly, this may affect absorption and metabolism of a drug. The principles of chrono-pharmacology can provide significant inputs to improve safety and efficacy profiles of drugs. More research studies are needed to establish principles of chrono-pharmacology in current clinical practice. It is still a developing science in today's era. However, ayurvedic rishis have known about it for thousands of years.
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This article describes the time of administration of medicine and its application in clinical practice.
This article describes the time of administration of medicine and its application in clinical practice.
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