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* Therapeutic purgation (virechana) [Cha.Sa. [[Siddhi Sthana]] 1/18]
* Therapeutic purgation (virechana) [Cha.Sa. [[Siddhi Sthana]] 1/18]
== Future areas of research ==
==Current researches==
'''Review articles exploring the Physiological aspects of agni '''
Many review articles throwing light upon understanding the physiological functioning of Agni in context to jatharagni are available in the public domain. Few important points like the explanation of the digestive and metabolic functions of Agni mention of various types of dietetic materials are digested by their own agni ([[bhutagni]]), encouraged and enhanced by antaragni (jatharagni), which is further digested and metabolized by [[dhatvagni]] to associate the body with the nutritional strength, complexion and happy life along with providing energy to the seven dhatus are discussed in the articles.<ref>Agrawal AK, Yadav CR, Meena MS. Physiological aspects of Agni. Ayu. 2010 Jul;31(3):395-8. doi: 10.4103/0974-8520.77159. PMID: 22131747; PMCID: PMC3221079</ref>
'''Jatharagni and Prakriti of young Indian adult population: A descriptive cross-sectional study'''
Agni is dynamic in nature and hence is responsible for all types of transformations in the body. It plays a very important role in the growth, development and maintenance of the body. There is a definite type of jatharagni for a particular [[prakriti]] and this is pre-determined at the time of conception. Understanding one's own agni and [[prakriti]] helps individuals choose a specific diet and regimes for a healthy life. One Observational study was planned on this concept. The study establishes the association between agni and dvandvaja (mixed with two dosha) [[prakriti]]. It was observed that vata-pitta prakriti individuals had teekshnagni, vata-kapha prakriti individuals had mandagni, and kapha-pitta prakriti had vishamagni. Although the results were promising, they should be proven with a larger sample size in different populations.<ref>Kuttikrishnan M, Sridhar R, Varghese EJatharagni and Prakriti of young Indian adult population: A descriptive cross-sectional study. J Ayurveda Integr Med. 2022 Jan-Mar;13(1):100438. doi: 10.1016/j.jaim.2021.04.008. Epub 2022 Jan 29. PMID: 35101333; PMCID: PMC9034458.</ref>
'''Formation and validation of questionnaire to assess jatharagni '''
The assessment of the state of agni is very crucial in the practice of [[ayurveda]]. It acts as a window first to understand the individual's digestive system. Secondly the metabolism (digestion and absorption) of the food and medicine in an individual is based on the state of agni. There are very few or no tools based on Ayurveda to assess agni. Interviewing an individual based on a questionnaire will serve as effective tool in analysing the state of agni.<ref>Eswaran HT, Kavita MB, Tripaty TB, Shivakumar. Formation and validation of questionnaire to assess Jāṭharāgni. Anc Sci Life. 2015 Apr-Jun;34(4):203-9. doi: 10.4103/0257-7941.159829. PMID: 26283805; PMCID: PMC4535068.</ref>
'''Efficacy of samsarjana krama in a patient with agnimandya due to vyadhi sankar: A case study'''
The effect of agni on thermoregulation, bio-energetics, pharmacological mechanisms are some key areas of research.
The case mentioned above was diagnosed with vyadhi sankara (complicated disease condition) in terms of [[ayurveda]], patient’s condition was deteriorating, because of the agnimandya. The dietary advice was given on the line of sansarjana krama in order to improve the status of agni, which was the root cause for multiple ailments. The agni improved and also nutritional status showed a little improvement with relief of symptoms like nausea, palpitation, pallor and cracking of lips after treatment.<ref>Mukta, Rao MV, Arora J.Efficacy of Samsarjanakrama in a patient with Agnimandya due to vyadhi sankar: A case study. J Ayurveda Integr Med. 2021 Jan-Mar;12(1):182-186. doi: 10.1016/j.jaim.2021.01.004. Epub 2021 Feb 27. PMID: 33648827; PMCID: PMC8039330.</ref>
=== Theses done ===
=== Theses done ===
10. Deshmukh Saylee H- 2014 : Fundamental and Applied aspect of Lifestyle in Ayurveda classics and its role in Agnimandya, Dept. of Basic Principles, I.P.G.T.& R.A. Jamnagar, 2014.
10. Deshmukh Saylee H- 2014 : Fundamental and Applied aspect of Lifestyle in Ayurveda classics and its role in Agnimandya, Dept. of Basic Principles, I.P.G.T.& R.A. Jamnagar, 2014.
== Future areas of research ==
Research is needed to study the biological effects of various factors mentioned above. The role of hormones like insulin, thyroid hormones, growth hormones in regulating tissue metabolism is well studied. However, the pharmacological effect of various dietary recipes, lifestyle factors and medicinal formulations on these hormones needs to be elaborated. The focused study on relation of agni with theories of epigenetics, inflammation, gut microbiome can produce insightful outcomes and new treatment options.
The personalized medicine and personalized diet patterns depend completely of individualistic patterns of agni. The concept can provide leads beyond current theories of calorie consumption and nutrition.
The effect of agni on thermoregulation, bio-energetics, pharmacological mechanisms are some key areas of research.
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