Changes

===== II. Platelet abnormalities =====

===== II. Platelet abnormalities =====

#Thrombocytopenia: ① Diminished or defective platelet production: aplastic anemia, marrow infiltration (carcinoma, leukemia, myelofibrosis, tuberculosis, etc), infections, drugs that act on platelet production (alcohol, thiazide diuretics).② Enhanced platelet destruction: idiopathic thrombocytopenic purpura, drug-induced, thrombotic thrombocytopenic purpura. ③Sequestration of platelets: hypersplenism

#Thrombocytopenia:

#Thrombocytosis: ① Primary: essential thrombocythemia.② Secondary: infections, injury, post-splenectomy chronic myelocytic leukemia, other myeloproliferative disorders (such as polycythemia vera)

##Diminished or defective platelet production: aplastic anemia, marrow infiltration (carcinoma, leukemia, myelofibrosis, tuberculosis, etc), infections, drugs that act on platelet production (alcohol, thiazide diuretics).

#Functional abnormalities of platelets: ① Congenital: thrombasthenia, giant platelet syndrome (Bernard-Soulier syndrome). ② Acquired: due to drugs, uremia, liver diseases, dysproteinemias

##Enhanced platelet destruction: idiopathic thrombocytopenic purpura, drug-induced, thrombotic thrombocytopenic purpura. ##Sequestration of platelets: hypersplenism

#Thrombocytosis:  

##Primary: essential thrombocythemia.

##Secondary: infections, injury, post-splenectomy chronic myelocytic leukemia, other myeloproliferative disorders (such as polycythemia vera)

#Functional abnormalities of platelets:  

##Congenital: thrombasthenia, giant platelet syndrome (Bernard-Soulier syndrome).  

##Acquired: due to drugs, uremia, liver diseases, dysproteinemias

===== III. Coagulation disorders due to coagulation factor deficiencies =====

===== III. Coagulation disorders due to coagulation factor deficiencies =====