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* The fourth chapter, [[Prameha Nidana]], involves ''meda dhatu'' predominantly  
 
* The fourth chapter, [[Prameha Nidana]], involves ''meda dhatu'' predominantly  
 
* The fifth chapter, [[Kushtha Nidana]], involves seven ''dushyas''  
 
* The fifth chapter, [[Kushtha Nidana]], involves seven ''dushyas''  
* The sixth chapter, [[Shosha Nidana]], deals with the pathology of emaciation
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* The sixth chapter, [[Sosha Nidana]], deals with the pathology of emaciation
 
* Lastly, the seventh, [[Unmada Nidana]] and the eighth chapters [[Apasmara Nidana]] explain psychiatric disorders like insanity and seizure disorders respectively.  
 
* Lastly, the seventh, [[Unmada Nidana]] and the eighth chapters [[Apasmara Nidana]] explain psychiatric disorders like insanity and seizure disorders respectively.  
    
''Prajnaparadha'' (intellectual errors, or knowingly violating rules) is the main responsible factor for causation of all endogenous and exogenous diseases. ''Asatmenriyarthasamyoga'' (improper union of senses with their objects) and ''parinama''(time) are other two causative factors . Therefore, this principle points that so called diseases of unknown etiology have a definite cause,  that needs to be searched and removed for its management.
 
''Prajnaparadha'' (intellectual errors, or knowingly violating rules) is the main responsible factor for causation of all endogenous and exogenous diseases. ''Asatmenriyarthasamyoga'' (improper union of senses with their objects) and ''parinama''(time) are other two causative factors . Therefore, this principle points that so called diseases of unknown etiology have a definite cause,  that needs to be searched and removed for its management.

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