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Normally, the ''dhatus'' of the body get metabolised (being acted upon) by their own ''ushmas'' or ''dhatvagnis'' (transforming enzymes in the tissue elements). From these ''dhatus'', (nutrient tissue elements), the other ''dhatus'' ( next ''dhatu'' to it that which receive nourishment) gets nourished through their respective ''srotas'' (channels of circulation). (For example, a ''poshaka rasa dhatu'' would nourish the ''rakta dhatu'' ).  
 
Normally, the ''dhatus'' of the body get metabolised (being acted upon) by their own ''ushmas'' or ''dhatvagnis'' (transforming enzymes in the tissue elements). From these ''dhatus'', (nutrient tissue elements), the other ''dhatus'' ( next ''dhatu'' to it that which receive nourishment) gets nourished through their respective ''srotas'' (channels of circulation). (For example, a ''poshaka rasa dhatu'' would nourish the ''rakta dhatu'' ).  
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Once, however, there is any obstruction to ''srotas'' or if there is diminution of stable tissue elements like ''rakta'' or if there is diminution of ''dhatu-ushmas'' or ''dhatvagnis'' then ''rajayakshma'' is manifested. In such a case, whatever food is digested in the gastrointestinal tract by jatharagni is mostly reduced to waste products and very little of it contributes to the formation of ojas (nourishment). The patient is depleted of all tissue elements and strength. The patient’s stool should be preserved and it is the only source of strength left with him. Because of the obstruction to the srotas, rasa dhatu becomes vidagdha (improperly metabolised) in its own location (heart) and this vitiated rasa comes out through the upper passages in different forms by way of coughing. Subsequently, six or eleven symptoms (or forms of diseases) are manifested, and their aggregation is the syndrome called rajayakshma. Cough, distress in shoulder, change of voice, fever, pain in flanks, headache, vomiting of rakta and kapha, dyspnoea, diarrhea and anorexia are the eleven symptoms of rajayakshma ; or they are also six viz., cough, fever, pain in flanks, hoarseness of voice diarrhea and anorexia. With eleven, six or even three of the symptoms, a patient is incurable if he is losing mamsa (flesh tissues) and strength, but he is curable if he is behaving otherwise in spite of showing all the symptoms. [39-47]
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Once, however, there is any obstruction to ''srotas'' or if there is diminution of stable tissue elements like ''rakta'' or if there is diminution of ''dhatu-ushmas'' or ''dhatvagnis'' then ''rajayakshma'' is manifested. In such a case, whatever food is digested in the gastrointestinal tract by ''jatharagni'' is mostly reduced to waste products and very little of it contributes to the formation of ''ojas'' (nourishment). The patient is depleted of all tissue elements and strength. The patient’s stool should be preserved and it is the only source of strength left with him. Because of the obstruction to the ''srotas, rasa dhatu'' becomes ''vidagdha'' (improperly metabolized) in its own location (heart) and this vitiated ''rasa'' comes out through the upper passages in different forms by way of coughing. Subsequently, six or eleven symptoms (or forms of diseases) are manifested, and their aggregation is the syndrome called ''rajayakshma''. Cough, distress in shoulder, change of voice, fever, pain in flanks, headache, vomiting of ''rakta'' and ''kapha'', dyspnea, diarrhea and anorexia are the eleven symptoms of ''rajayakshma'' ; or they are also six viz., cough, fever, pain in flanks, hoarseness of voice diarrhea and anorexia. With eleven, six or even three of the symptoms, a patient is incurable if he is losing ''mamsa'' (flesh tissues) and strength, but he is curable if he is behaving otherwise in spite of showing all the symptoms. [39-47]
    
==== Signs of pratishyaya ====
 
==== Signs of pratishyaya ====

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