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''Rajayakshma'' has been identified since Vedic period (2400 BC). ''Yakshma'',the word, first appeared in the vedas (Rigveda and Atharvaveda), but a detailed description was missing. In the Ayurvedic treatises, or the Samhitas (1000 BC to 500 AD), a detailed description of ''rajayakshma'' can be found. An account of its definition, etiology, pathogenesis, general features, management, and the prognosis is found in [[Charaka Samhita]], ''Sushruta Samhita'', and ''Ashtanga Hridaya'' with more extensive description is in [[Charaka Samhita]]. Four etiological factors are described, ''sahasa'' (over exertion or working beyond one's capacity), ''samdharana'' (suppression of natural urges), ''kshaya'' (depletion of tissue element) and ''vishamashana'' (irregular diet).  
 
''Rajayakshma'' has been identified since Vedic period (2400 BC). ''Yakshma'',the word, first appeared in the vedas (Rigveda and Atharvaveda), but a detailed description was missing. In the Ayurvedic treatises, or the Samhitas (1000 BC to 500 AD), a detailed description of ''rajayakshma'' can be found. An account of its definition, etiology, pathogenesis, general features, management, and the prognosis is found in [[Charaka Samhita]], ''Sushruta Samhita'', and ''Ashtanga Hridaya'' with more extensive description is in [[Charaka Samhita]]. Four etiological factors are described, ''sahasa'' (over exertion or working beyond one's capacity), ''samdharana'' (suppression of natural urges), ''kshaya'' (depletion of tissue element) and ''vishamashana'' (irregular diet).  
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The three chapters viz. [[Shosha Nidana]], [[Rajayakshma Chikitsa]] and [[Kshatakshina Chikitsa]] deal with similar clinical presentation of disease and priniciples of management. Dhatukshaya is common feature in all. Advancement of dhatukshaya in shosha reaches a stage when immunosuppression with resulting opportunistic infection occurs and is called rajyakshma.  In kshatshina or urakshata there is chest injury due to direct or indirect trauma along with dhatukshaya. Brumhana of dhatu (nourishment) is the priniciple line of management.  
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The three chapters viz. [[Sosha Nidana]], [[Rajayakshma Chikitsa]] and [[Kshatakshina Chikitsa]] deal with similar clinical presentation of disease and priniciples of management. Dhatukshaya is common feature in all. Advancement of dhatukshaya in shosha reaches a stage when immunosuppression with resulting opportunistic infection occurs and is called rajyakshma.  In kshatshina or urakshata there is chest injury due to direct or indirect trauma along with dhatukshaya. Brumhana of dhatu (nourishment) is the priniciple line of management.  
 
Thus 'upsarga'(addional contact or exposure to) may be considered as "Sannikrishta Nidana" (recent cause) of rajayakshma. Sushruta was aware of this fact, and he has described its contagious nature by saying that skin diseases, fever, rajayakshma and conjunctivitis are infectious diseases which spread from one man to another man.
 
Thus 'upsarga'(addional contact or exposure to) may be considered as "Sannikrishta Nidana" (recent cause) of rajayakshma. Sushruta was aware of this fact, and he has described its contagious nature by saying that skin diseases, fever, rajayakshma and conjunctivitis are infectious diseases which spread from one man to another man.
  

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