Nidana Sthana Chapter 2. Diagnosis and etiopathogenesis of Bleeding Disorders
Keywords: Etio-pathogenesis of raktapitta, bleeding disorders, epistaxis, hemorrhage, hematemesis, rectal bleeding.
|Section/Chapter||Nidana Sthana Chapter 2|
|Preceding Chapter||Jwara Nidana|
|Succeeding Chapter||Gulma Nidana|
|Other Sections||Sutra Sthana, Vimana Sthana, Sharira Sthana, Indriya Sthana, Chikitsa Sthana, Kalpa Sthana, Siddhi Sthana|
- 1 Introduction
- 2 Sanskrit Text, Transliteration and English Translation
- 3 Tattva Vimarsha (Fundamental principles)
- 4 Vidhi Vimarsha (Applied Inferences)
- 4.1 Vitamin K
- 4.2 Omega-3 Fatty Acids
- 4.3 Alcohol
- 4.4 Excess heat
- 4.5 Hereditary issues
- 4.6 Pathophysiology of Bleeding/Hemorrhagic Disorders in modern medicine
- 4.7 Causes of Bleeding
- 4.8 Correlation between Ayurvedic knowledge and Western medicine
- 4.9 Summary
- 4.10 Related Chapters
- 5 References
The second chapter of the Nidana Sthana focuses on rakta, the second dhatu, just as the first chapter on jwara focused on the first dhatu, rasa. Pitta is the primary cause of jwara which causes elevated temperature, leading to raktapitta. Thus it can be said that jwara is a cause of raktapitta, and an aggravated pitta is the cause of both jwara and raktapitta.
Bleeding disorders also include conditions where bleeding is not apparent. Hemorrhagic strokes, vessel diseases, and heart attacks cause internal bleeding and do not erupt through the skin or orifices. These are typically due to vascular and other events and not caused due to raktapitta. These disorders should be classified under avarana and shiragata vata.
Raktapitta manifests through two broadly divided routes that correlate with the flow of dosha energies in the body: the upper tract and the lower tract. The upper tract includes the orifices of eyes, ear, nose, and mouth/throat and is the route taken by the flow of blood when the person has an abundance of body kapha besides rakta and pitta. When there is an abundance of body vata with an interplay of rakta and pitta, raktapitta manifests through the lower tract using urine via hematuria and feces via occult blood. When bleeding manifests through both the routes, it indicates the involvement of both the doshas, vata and kapha.
Raktapitta from the upper orifices is curable, while that from the lower orifices is considered palliable. Manifestation of bleeding from both the tracts is said to be incurable. Charak advocates that in order to avoid progression to this stage, prompt preventive action should be taken.
Sanskrit Text, Transliteration and English Translation
athātō raktapittanidānaṁ vyākhyāsyāmaḥ||1||
iti ha smāha bhagavānātrēyaḥ||2||
athAto raktapittanidAnaM vyAkhyAsyAmaH||1||
iti ha smAha bhagavAnAtreyaH||2||
Now we shall expound the chapter "Raktapitta Nidana" (Diagnosis and etiopathogenesis of Bleeding Disorders). Thus said Lord Atreya.[1-2]
Synonym of raktapitta
पित्तं यथाभूतं लोहितपित्तमिति सञ्ज्ञां लभते, तद्व्याख्यास्यामः||३||
pittaṁ yathābhūtaṁ lōhitapittamiti sañjñāṁ labhatē, tad  vyākhyāsyāmaḥ||3||
pittaM yathAbhUtaM lohitapittamiti sa~jj~jAM labhate, tad  vyAkhyAsyAmaH||3||
Also explained would be the origin of lohitapitta as an alternate name for pitta. 
यदा जन्तुर्यवकोद्दालककोरदूषप्रायाण्यन्नानि भुङ्क्ते, भृशोष्णतीक्ष्णमपि चान्यदन्नजातं निष्पावमाषकुलत्थसूपक्षारोपसंहितं, दधिदधिमण्डोदश्वित्कट्वराम्लकाञ्जिकोपसेकं वा, वाराहमाहिषाविकमात्स्यगव्यपिशितं, पिण्याकपिण्डालुशुष्कशाकोपहितं, मूलकसर्षपलशुन-करञ्ज-शिग्रुमधुशिग्रु(खडयूष) भूस्तृणसुमुखसुरसकुठेरकगण्डीरकालमालकपर्णासक्षवकफ-णिज्झ-कोपदंशं, सुरासौवीरतुषोदकमैरेयमेदकमधूलकशुक्तकुवलबदराम्लप्रायानुपानं वा, पिष्टान्नोत्तरभूयिष्ठम्; उष्णाभितप्तो वाऽतिमात्रमतिवेलं वाऽऽमं पयः पिबति, पयसा समश्नाति रौहिणीकं काणकपोतं वा सर्षपतैलक्षारसिद्धं, कुलत्थपिण्याकजाम्बवलकुचपक्वैः शौक्तिकैर्वा सह क्षीरं बत्युष्णाभितप्तः तस्यैवमाचरतः पित्तं प्रकोपमापद्यते, लोहितं च स्वप्रमाणमतिवर्तते तस्मिन् प्रमाणातिवृत्ते पित्तं प्रकुपितं शरीरमनुसर्पद्यदेव यकृत्प्लीहप्रभवाणां लोहितवहानां च स्रोतसां लोहिताभिष्यन्दगुरूणि मुखान्यासाद्य प्रतिरुन्ध्यात् तदेव लोहितं दूषयति||४||
yadā janturyavakōddālakakōradūṣaprāyāṇyannāni bhuṅktē, bhr̥śōṣṇatīkṣṇamapi cānyadannajātaṁ niṣpāvamāṣakulatthasūpakṣārōpasaṁhitaṁ,dadhidadhimaṇḍōdaśvitkaṭvarāmlakāñjikōpasēkaṁ  vā, vārāhamāhiṣāvikamātsyagavyapiśitaṁ, piṇyākapiṇḍāluśuṣkaśākōpahitaṁ,mūlakasarṣapalaśunakarañjaśigrumadhuśigru(khaḍayūṣa  ) bhūstr̥ṇasumukhasurasakuṭhērakagaṇḍīrakālamālakaparṇāsakṣavakaphaṇijjhakōpadaṁśaṁ,surāsauvīratuṣōdakamairēyamēdakamadhūlakaśuktakuvalab
pānaṁ vā, piṣṭānnōttarabhūyiṣṭham; uṣṇābhitaptō vā'timātramativēlaṁ vāmaṁpayaḥ pibati, payasā samaśnāti rauhiṇīkaṁ  , kāṇakapōtaṁ vā sarṣapatailakṣārasiddhaṁ, kulatthapiṇyākajāmbavalakucapakvaiḥ śauktikairvā saha kṣīraṁpibatyuṣṇābhitaptaḥ  ; tasyaivamācarataḥ pittaṁ prakōpamāpadyatē, lōhitaṁ ca  svapramāṇamativartatē| tasmin pramāṇātivr̥ttē pittaṁ prakupitaṁ śarīramanusarpadyadēva  yakr̥tplīhaprabhavāṇāṁ lōhitavahānāṁ ca srōtasāṁ lōhitābhiṣyandagurūṇi mukhānyāsādyapratirundhyāt  tadēva  lōhitaṁ dūṣayati||4||
yadA janturyavakoddAlakakoradUShaprAyANyannAni bhu~gkte, bhRushoShNatIkShNamapi cAnyadannajAtaM niShpAvamAShakulatthasUpakShAropasaMhitaM,dadhidadhimaNDodashvitkaTvarAmlakA~jjikopasekaM  vA, vArAhamAhiShAvikamAtsyagavyapishitaM, piNyAkapiNDAlushuShkashAkopahitaM,mUlakasarShapalashunakara~jjashigrumadhushigru(khaDayUSha )bhUstRuNasumukhasurasakuTherakagaNDIrakAlamAlakaparNAsakShavakaphaNijjhakopadaMshaM,surAsauvIratuShodakamaireyamedakamadhUlakas
huktakuvalabadarAmlaprAyAnupAnaM vA, piShTAnnottarabhUyiShTham; uShNAbhitapto vA~atimAtramativelaMvA~a~amaM payaH pibati, payasA samashnAti rauhiNIkaM , kANakapotaM vA sarShapatailakShArasiddhaM, kulatthapiNyAkajAmbavalakucapakvaiH shauktikairvAsaha kShIraM pibatyuShNAbhitaptaH  ; tasyaivamAcarataH pittaM prakopamApadyate, lohitaM ca  svapramANamativartate| tasmin pramANAtivRutte pittaM prakupitaM sharIramanusarpadyadeva  yakRutplIhaprabhavANAM lohitavahAnAM ca srotasAM lohitAbhiShyandagurUNimukhAnyAsAdya pratirundhyAt  tadeva  lohitaM dUShayati||4||
When a person consumes a diet or food consisting mostly of:
- Grains such as yavaka, uddalaka, and koradusha, in excess quantities, along with other food items that are ushna (hot in potency) and tikshna ( sharply acting) such as legumes of nishpaava, black gram, horse gram and alkali, or with curd, whey, buttermilk, sour buttermilk or sour gruel
- Meat of pig, buffalo, sheep, fish and cow,
- Vegetables of oil cake, pindalu (a tuber) and dried potherbs
- Upadamsha (chutney or salad) of radish, mustard, garlic, karanja, shigru, madhu shigru, kharabusa, bhustruna, sumukha, surasa, kutheraka, gandira, kalamala, parnasa, kshavaka and phanijzaka
- Drink of sura (wine), sauvira, tushodaka (types of vinegar), maireya, medaka, madhulaka (fermented beverages), shukta (sour beverage), sour preparations of kuvala and badara (types of jujube)
- Preparations of (rice) flour in excess after meals
- Excessive quantities of pishtanna (triturated grains)
- Unboiled milk in excessive quantity or frequently, especially after exposure to intense heat, or when recovering from a heat-stroke
- Rohini (vegetable) along with milk
- Kanakapota (a type of pigeon) cooked with mustard oil and alkali
- Milk along with sour beverages cooked with horse gram, oil cake, fruits or jambu and lakucha, when taken after exposure to intense heat.
With such food articles, a person’s pitta gets vitiated and the quantity of blood in his body exceeds its normal quantity. Along with the increased quantity of vitiated blood in the system, vitiated pitta gets into the circulation and reaches raktavaha srotas and its organs like liver and spleen. Due to abhishyandi and guru qualities of rakta, obstructions in the channels occur leading to morbidity in rakta. 
संसर्गाल्लोहितप्रदूषणाल्लोहितगन्धवर्णानुविधानाच्च पित्तं लोहितपित्तमित्याचक्षते||५||
saṁsargāllōhitapradūṣaṇāllōhitagandhavarṇānuvidhānācca  pittaṁ lōhitapittamityācakṣatē||5||
saMsargAllohitapradUShaNAllohitagandhavarNAnuvidhAnAcca  pittaM lohitapittamityAcakShate||5||
Pitta gets the name lohitapitta because after mixing with blood it acquires the color and smell of blood. 
तस्येमानि पूर्वरूपाणि भवन्ति; तद्यथा- अनन्नाभिलाषः, भुक्तस्य विदाहः, शुक्ताम्लगन्धरस उद्गारः, छर्देरभीक्ष्णमागमनं, छर्दितस्य बीभत्सता, स्वरभेदो, गात्राणां सदनं, परिदाहः, मुखाद्धूमागम इव, लोहलोहितमत्स्यामगन्धित्वमिव चास्यस्य, रक्तहरितहारिद्रत्वमङ्गावयवशकृन्मूत्रस्वेदलालासिङ्घाणकास्यकर्णमलपिडकोलिकापिडकानाम्, अङ्गवेदना, लोहितनीलपीतश्यावानामर्चिष्मतां च रूपाणां स्वप्ने दर्शनमभीक्ष्णमिति (लोहितपित्तपूर्वरूपाणि भवन्ति)||६||
tasyēmāni pūrvarūpāṇi bhavanti; tadyathā- anannābhilāṣaḥ, bhuktasya vidāhaḥ, śuktāmlagandharasa udgāraḥ, chardērabhīkṣṇamāgamanaṁ, charditasyabībhatsatā, svarabhēdō, gātrāṇāṁ sadanaṁ, paridāhaḥ, mukhāddhūmāgama iva, lōhalōhitamatsyāmagandhitvamiva cāsyasya,raktaharitahāridratvamaṅgāvayavaśakr̥nmūtrasvēdalālāsiṅghāṇakāsyakarṇamalapiḍakōlikāpiḍakānām  , aṅgavēdanā, lōhitanīlapītaśyāvānāmarciṣmatāṁ carūpāṇāṁ svapnē darśanamabhīkṣṇamiti (lōhitapittapūrvarūpāṇi  bhavanti)||6||
tasyemAni pUrvarUpANi bhavanti; tadyathA- anannAbhilAShaH, bhuktasya vidAhaH, shuktAmlagandharasa udgAraH, charderabhIkShNamAgamanaM, charditasyabIbhatsatA, svarabhedo, gAtrANAM sadanaM, paridAhaH, mukhAddhUmAgama iva, lohalohitamatsyAmagandhitvamiva cAsyasya,raktaharitahAridratvama~ggAvayavashakRunmUtrasvedalAlAsi~gghANakAsyakarNamalapiDakolikApiDakAnAm  , a~ggavedanA,lohitanIlapItashyAvAnAmarciShmatAM ca rUpANAM svapne darshanamabhIkShNamiti (lohitapittapUrvarUpANi  bhavanti)||6||
The prodromal symptoms of raktapitta include aversion to food, hot eructation just after meal, belches with smell and aftertaste of sour gruel, frequent vomiting, ugliness of vomitus, hoarseness of voice, malaise, radiating burning sensation, emittance of smoke from the mouth, smell of metal, blood, or fish , mucus in the mouth, appearance of red, green or yellow spots in body parts, feces, urine, sweat, saliva, nose-secretion, excreta from mouth and ear and boils, bodyache, and frequent vision of red, blue, yellow, blackish and brilliant objects in dreams. 
उपद्रवास्तु खलु दौर्बल्यारोचकाविपाकश्वासकासज्वरातीसारशोफशोषपाण्डुरोगाः स्वरभेदश्च||७||
upadravāstu khalu daurbalyārōcakāvipākaśvāsakāsajvarātīsāraśōphaśōṣapāṇḍurōgāḥ svarabhēdaśca||7||
upadravAstu khalu daurbalyArocakAvipAkashvAsakAsajvarAtIsArashophashoShapANDurogAH svarabhedashca||7||
Complications (of raktapitta) include debility, anorexia, indigestion, dyspnea, cough, fever, diarrhea, edema, emaciation, anemia and hoarseness of voice. 
मार्गौ पुनरस्य द्वौ ऊर्ध्वं, चाधश्च तद्बहुश्लेष्मणि शरीरे श्लेष्मसंसर्गादूर्ध्वं प्रतिपद्यमानं कर्णनासिकानेत्रास्येभ्यः प्रच्यवते, बहुवाते तु शरीरे वातसंसर्गादधः प्रतिपद्यमानं मूत्रपुरीषमार्गाभ्यां प्रच्यवते, बहुश्लेष्मवाते तु शरीरे श्लेष्मवातसंसर्गाद्द्वावपि मार्गौ प्रतिपद्यते, तौ मार्गौ प्रतिपद्यमानं सर्वेभ्य एव यथोक्तेभ्यः खेभ्यः प्रच्यवते शरीरस्य||८||
mārgau punarasya dvau ūrdhvaṁ, cādhaśca| tadbahuślēṣmaṇi śarīrē ślēṣmasaṁsargādūrdhvaṁ pratipadyamānaṁ karṇanāsikānētrāsyēbhyaḥ pracyavatē, bahuvātē tu śarīrē vātasaṁsargādadhaḥpratipadyamānaṁ mūtrapurīṣamārgābhyāṁ pracyavatē, bahuślēṣmavātē tu śarīrē ślēṣmavātasaṁsargāddvāvapi mārgau pratipadyatē, tau mārgaupratipadyamānaṁ sarvēbhya ēva yathōktēbhyaḥ khēbhyaḥ pracyavatē śarīrasya||8||
mArgau punarasya dvau UrdhvaM, cAdhashca| tadbahushleShmaNi sharIre shleShmasaMsargAdUrdhvaM pratipadyamAnaM karNanAsikAnetrAsyebhyaH pracyavate, bahuvAte tu sharIre vAtasaMsargAdadhaHpratipadyamAnaM mUtrapurIShamArgAbhyAM pracyavate, bahushleShmavAte tu sharIre shleShmavAtasaMsargAddvAvapi mArgau pratipadyate, tau mArgaupratipadyamAnaM sarvebhya eva yathoktebhyaH khebhyaH pracyavate sharIrasya||8||
There are two routes of the manifestation of raktapitta - upwards and downwards. In persons having an abundance of kapha, vitiated rakta goes up and bleeding occurs from ear, nose, eyes and mouth. In those having an excess of vata, rakta flows downwards along with vata and patients bleed through the urinary tract and rectum. Finally, in those having abundance of both kapha and vata, rakta comes out from the body with both the routes and thus bleeds through all the aforesaid orifices. 
तत्र यदूर्ध्वभागं तत् साध्यं, विरेचनोपक्रमणीयत्वाद्बह्वौषधत्वाच्च; यदधोभागं तद्याप्यं, वमनोपक्रमणीयत्वादल्पौषधत्वाच्च; यदुभयभागं तदसाध्यं, वमनविरेचनायोगित्वादनौषधत्वाच्चेति||९||
tatra yadūrdhvabhāgaṁ tat sādhyaṁ, virēcanōpakramaṇīyatvādbahvauṣadhatvācca; yadadhōbhāgaṁ tadyāpyaṁ, vamanōpakramaṇīyatvādalpauṣadhatvācca;yadubhayabhāgaṁ tadasādhyaṁ, vamanavirēcanāyōgitvādanauṣadhatvāccēti||9||
tatra yadUrdhvabhAgaM tat sAdhyaM, virecanopakramaNIyatvAdbahvauShadhatvAcca; yadadhobhAgaM tadyApyaM, vamanopakramaNIyatvAdalpauShadhatvAcca;yadubhayabhAgaM tadasAdhyaM, vamanavirecanAyogitvAdanauShadhatvAcceti||9||
Amongst these, that which comes out of the upper orifices is curable and is treatable by purgation due to availability of plenty of drugs for the purpose. That coming out from the lower orifices is palliable because of being amenable to emesis and availability of lesser number of drugs for the purpose. That coming out from both the routes is incurable because of non-applicability of both emesis and purgation and in want of suitable drugs. (9)
Origin of raktapitta
रक्तपित्तप्रकोपस्तु खलु पुरा दक्षयज्ञोद्ध्वंसे रुद्रकोपामर्षाग्निना प्राणिनां परिगतशरीरप्राणानामभवज्ज्वरमनु||१०||
raktapittaprakōpastu khalu purā dakṣayajñōddhvaṁsē rudrakōpāmarṣāgninā  prāṇināṁ parigataśarīraprāṇānāmabhavajjvaramanu||10||
raktapittaprakopastu khalu purA dakShayaj~joddhvaMse rudrakopAmarShAgninA  prANinAM parigatasharIraprANAnAmabhavajjvaramanu||10||
Hystorically, raktapitta occured after jwara because of Rudra’s anger pervaded the human being at the time of destruction of Daksha's sacrifice. 
General principles of management
तस्याशुकारिणो दावाग्नेरिवापतितस्यात्ययिकस्याशु प्रशान्त्यै प्रयतितव्यं मात्रां देशं कालं चाभिसमीक्ष्य सन्तर्पणेनापतर्पणेन वा मृदुमधुरशिशिरतिक्तकषायैरभ्यवहार्यैः प्रदेहपरिषेकावगाहसंस्पर्शनैर्वमनाद्यैर्वा तत्रावहितेनेति||११||
tasyāśukāriṇō dāvāgnērivāpatitasyātyayikasyāśu praśāntyai prayatitavyaṁ mātrāṁ dēśaṁ kālaṁ cābhisamīkṣya santarpaṇēnāpatarpaṇēna vāmr̥dumadhuraśiśiratiktakaṣāyairabhyavahāryaiḥ pradēhapariṣēkāvagāhasaṁsparśanairvamanādyairvā tatrāvahitēnēti||11||
tasyAshukAriNo dAvAgnerivApatitasyAtyayikasyAshu prashAntyai prayatitavyaM mAtrAM deshaM kAlaM cAbhisamIkShya santarpaNenApatarpaNena vAmRudumadhurashishiratiktakaShAyairabhyavahAryaiH pradehapariShekAvagAhasaMsparshanairvamanAdyairvA tatrAvahiteneti||11||
The disease is acute in nature and becomes critical very quickly, spreading like bush fire. Hence its treatment should be done immediately with saturating or de-saturating soft, sweet, cold, bitter and astringent diet and pastes, baths, emesis etc. after due consideration of dose, place and time. 
भवन्ति चात्र- साध्यं लोहितपित्तं तद्यदूर्ध्वं प्रतिपद्यते|
विरेचनस्य योगित्वाद्बहुत्वाद्भेषजस्य च||१२||
विरेचनं तु पित्तस्य जयार्थे परमौषधम्|
यश्च तत्रान्वयः श्लेष्मा तस्य चानधमं स्मृतम्||१३||
भवेद्योगावहं तत्र मधुरं चैव भेषजम्|
तस्मात् साध्यं मतं रक्तं यदूर्ध्वं प्रतिपद्यते||१४||
bhavanti cātra- sādhyaṁ lōhitapittaṁ tadyadūrdhvaṁ pratipadyatē|
virēcanasya yōgitvādbahutvādbhēṣajasya ca||12||
virēcanaṁ tu pittasya jayārthē paramauṣadham|
yaśca tatrānvayaḥ  ślēṣmā tasya cānadhamaṁ smr̥tam||13||
bhavēdyōgāvahaṁ tatra madhuraṁ  caiva bhēṣajam|
tasmāt sādhyaṁ mataṁ raktaṁ yadūrdhvaṁ pratipadyatē||14||
bhavanti cAtra- sAdhyaM lohitapittaM tadyadUrdhvaM pratipadyate|
virecanasya yogitvAdbahutvAdbheShajasya ca||12||
virecanaM tu pittasya jayArthe paramauShadham|
yashca tatrAnvayaH  shleShmA tasya cAnadhamaM smRutam||13||
bhavedyogAvahaM tatra madhuraM  caiva bheShajam|
tasmAt sAdhyaM mataM raktaM yadUrdhvaM pratipadyate||14||
The “upward” variety of raktapitta is curable because of applicability of purgation and abundance of useful drugs. Purgation is the best remedy for alleviation of pitta and ambivalence to kapha. Sweet drugs are also applicable in this case. Hence, bleeding from the upper part is curable. [12-14]
रक्तं तु यदधोभागं तद्याप्यमिति निश्चितम्|
वमनं हि न पित्तस्य हरणे श्रेष्ठमुच्यते|
यश्च तत्रान्वयो वायुस्तच्छान्तौ चावरं स्मृतम्||१६||
तच्चायोगावहं तत्र कषायं तिक्तकानि च|
तस्माद्याप्यं समाख्यातं यदुक्तमनुलोमगम्||१७||
raktaṁ tu yadadhōbhāgaṁ tadyāpyamiti niścitam|
vamanaṁ hi na pittasya haraṇē  śrēṣṭhamucyatē|
yaśca tatrānvayō  vāyustacchāntau cāvaraṁ smr̥tam||16||
taccāyōgāvahaṁ  tatra kaṣāyaṁ tiktakāni ca|
tasmādyāpyaṁ samākhyātaṁ yaduktamanulōmagam  ||17||
raktaM tu yadadhobhAgaM tadyApyamiti nishcitam|
vamanaM hi na pittasya haraNe  shreShThamucyate|
yashca tatrAnvayo  vAyustacchAntau cAvaraM smRutam||16||
taccAyogAvahaM  tatra kaShAyaM tiktakAni ca|
tasmAdyApyaM samAkhyAtaM yaduktamanulomagam  ||17||
Hemorrhage from the lower parts is decidedly palliable because emesis has limited efficacy here and effective drugs are also a few. Emesis is not so efficacious for elimination of pitta and it is also ineffective in alleviation of vata responsible for the downward flow. Moreover, astringents and bitter drugs are not applicable there. Hence hemorrhage from the lower parts is considered palliable. [15-17]
रक्तपित्तं तु यन्मार्गौ द्वावपि प्रतिपद्यते|
असाध्यमिति तज्ज्ञेयं पूर्वोक्तादेव कारणात्||१८||
नहि संशोधनं किञ्चिदस्त्यस्य प्रतिमार्गगम्|
प्रतिमार्गं च हरणं रक्तपित्ते विधीयते||१९||
एवमेवोपशमनं सर्वशो नास्य विद्यते|
संसृष्टेषु च दोषेषु सर्वजिच्छमनं मतम् ||२०||
इत्युक्तं त्रिविधोदर्कं रक्तं मार्गविशेषतः||२१||
raktapittaṁ tu yanmārgau dvāvapi pratipadyatē|
asādhyamiti tajjñēyaṁ pūrvōktādēva kāraṇāt||18||
nahi saṁśōdhanaṁ kiñcidastyasya pratimārgagam|
pratimārgaṁ ca haraṇaṁ raktapittē vidhīyatē||19||
ēvamēvōpaśamanaṁ sarvaśō nāsya vidyatē|
saṁsr̥ṣṭēṣu ca dōṣēṣu sarvajicchamanaṁ matam  ||20||
ityuktaṁ trividhōdarkaṁ raktaṁ mārgaviśēṣataḥ|21|
raktapittaM tu yanmArgau dvAvapi pratipadyate|
asAdhyamiti tajj~jeyaM pUrvoktAdeva kAraNAt||18||
nahi saMshodhanaM ki~jcidastyasya pratimArgagam|
pratimArgaM ca haraNaM raktapitte vidhIyate||19||
evamevopashamanaM sarvasho nAsya vidyate|
saMsRuShTeShu ca doSheShu sarvajicchamanaM matam  ||20||
ityuktaM trividhodarkaM raktaM mArgavisheShataH|21|
In cases where blood comes out from both the routes, raktapitta is incurable because no effective evacuative measure is applicable. In raktapitta, elimination of dosha from the opposite route is recommended. Thus, the three types (on the basis of the routes taken by rakta) of raktapitta progression (udarka) have been described. [18-20]
एभ्यस्तु खलु हेतुभ्यः किञ्चित्साध्यं न सिध्यति||२१||
अकर्मतश्च साध्यत्वं कश्चिद्रोगोऽतिवर्तते||२२||
तत्रासाध्यत्वमेकं स्यात् साध्ययाप्यपरिक्रमात्|२३|
ēbhyastu khalu hētubhyaḥ kiñcitsādhyaṁ na sidhyati||21||
akarmataśca sādhyatvaṁ kaścidrōgō'tivartatē||22||
tatrāsādhyatvamēkaṁ syāt sādhyayāpyaparikramāt|23|
ebhyastu khalu hetubhyaH ki~jcitsAdhyaM na sidhyati||21||
akarmatashca sAdhyatvaM kashcidrogo~ativartate||22||
tatrAsAdhyatvamekaM syAt sAdhyayApyaparikramAt|23|
Some curable diseases do not get treated successfully because of the lack of attendants and equipments, uncontrolled self and fault of the physician. If the disease is not treated, then it proceeds to incurability. If treated well, sometimes the incurable disease may become curable or palliable. [21-23]
Signs of incurable raktapitta
रक्तपित्तस्य विज्ञानमिदं तस्योपदिश्यते||२३||
यत् कृष्णमथवा नीलं यद्वा शक्रधनुष्प्रभम्|
रक्तपित्तमसाध्यं तद्वाससो रञ्जनं च यत्||२४||
भृशं पूत्यतिमात्रं च सर्वोपद्रववच्च यत्|
बलमांसक्षये यच्च तच्च रक्तमसिद्धिमत्||२५||
येन चोपहतो रक्तं रक्तपित्तेन मानवः|
पश्येद्दृश्यं वियच्चापि तच्चासाध्यं न संशयः||२६||
raktapittasya vijñānamidaṁ tasyōpadiśyatē||23||
yat kr̥ṣṇamathavā nīlaṁ yadvā śakradhanuṣprabham|
raktapittamasādhyaṁ tadvāsasō rañjanaṁ ca yat||24||
bhr̥śaṁ pūtyatimātraṁ ca sarvōpadravavacca yat|
balamāṁsakṣayē yacca tacca raktamasiddhimat||25||
yēna cōpahatō raktaṁ raktapittēna mānavaḥ|
paśyēddr̥śyaṁ viyaccāpi taccāsādhyaṁ na saṁśayaḥ||26||
raktapittasya vij~jAnamidaM tasyopadishyate||23||
yat kRuShNamathavA nIlaM yadvA shakradhanuShprabham|
raktapittamasAdhyaM tadvAsaso ra~jjanaM ca yat||24||
bhRushaM pUtyatimAtraM ca sarvopadravavacca yat|
balamAMsakShaye yacca tacca raktamasiddhimat||25||
yena copahato raktaM raktapittena mAnavaH|
pashyeddRushyaM viyaccApi taccAsAdhyaM na saMshayaH||26||
Now described are types of raktapitta, identified (by their physical appearance). Raktapitta which is black, blue or of rainbow color and stains clothes is incurable. Bleeding which is of excessively fetid smell, in large quantities, and which is associated with all the complications particularly in weak and emaciated patients is incurable. A patient, if sees things around him and the sky red, is certainly suffering from an incurable variant of the disease. [23-26]
तत्रासाध्यं परित्याज्यं, याप्यं यत्नेन यापयेत्|
साध्यं चावहितः सिद्धैर्भेषजैः साधयेद्भिषक्||२७|
tatrāsādhyaṁ parityājyaṁ, yāpyaṁ yatnēna yāpayēt|
sādhyaṁ cāvahitaḥ siddhairbhēṣajaiḥ sādhayēdbhiṣak||27||
tatrAsAdhyaM parityAjyaM, yApyaM yatnena yApayet|
sAdhyaM cAvahitaH siddhairbheShajaiH sAdhayedbhiShak||27||
A patient suffering from the incurable variant should be avoided, while the one with the palliable variant should be managed with efforts and the curable one should be treated successfully with tried remedies. 
कारणं नामनिर्वृत्तिं पूर्वरूपाण्युपद्रवान्|
मार्गौ दोषानुबन्धं च साध्यत्वं न च हेतुमत्||२८||
निदाने रक्तपित्तस्य व्याजहार पुनर्वसुः|
tatra ślōkau- kāraṇaṁ nāmanirvr̥ttiṁ pūrvarūpāṇyupadravān|
mārgau dōṣānubandhaṁ ca sādhyatvaṁ na ca hētumat||28||
nidānē raktapittasya vyājahāra punarvasuḥ|
tatra shlokau- kAraNaM nAmanirvRuttiM pUrvarUpANyupadravAn|
mArgau doShAnubandhaM ca sAdhyatvaM na ca hetumat||28||
nidAne raktapittasya vyAjahAra punarvasuH|
Now summarizing the chapter–
Etiology, etymology of the disease, prodroma, complications, routes, association of doshas, curability (or otherwise), with reasoning – all this has been addressed in the chapter on diagnosis of raktapitta by Punarvasu who has shed off tamas and rajas, doshas, greed, conceit and pride. [28-29]
इत्यग्निवेशकृते तन्त्रे चरकप्रतिसंस्कृते|
निदानस्थाने रक्तपित्तनिदानं नाम द्वितीयोऽध्यायः||२||
ityagnivēśakr̥tē tantrē carakapratisaṁskr̥tē
nidānasthānē raktapittanidānaṁ nāma dvitīyō'dhyāyaḥ||2||
ityagniveshakRute tantre carakapratisaMskRute
nidAnasthAne raktapittanidAnaM nAma dvitIyo~adhyAyaH||2||
Thus ends the second chapter on diagnosis of raktapitta in Nidana Sthana in the treatise composed by Agnivesha and redacted by Charak. 
Tattva Vimarsha (Fundamental principles)
- Rakta and pitta have a cause-and-effect relationship because of their common origin, and this fact is important in the pathogenesis and manifestation of raktapitta.
- The amla (sour), lavana (salty), katu (pungent) food articles with ushna (hot potency), tikshna (sharply acting) lead to vitiation of pitta dosha and blood. This causes abhishyanda (excess discharge leading to increase in volume of fluid) and guru (heaviness) in blood. This results in obstruction of raktavaha srotasa rooted in yakrita(liver)-pleeha (spleen) and raktapitta (hemorrhage).
- Raktapitta disorders can be classified by the route of bleeding. The vitiated pitta and rakta if gets associated with vitiated kapha causes bleeding from the upper orifices in the body. While if associated with vitiated vata, it leads to bleeding from the lower orifices. Vitiation of all the three doshas, from the standpoint of raktapitta, is considered incurable.
- Purification therapy from the opposite route is unique for the treatment of raktapitta. If the bleeding is from upper orifices then purgation is done and if it is from the lower route then vamana is indicated.
- Prognosis is based on dosha, route, purification treatment, and availability of effective medicines.
Vidhi Vimarsha (Applied Inferences)
What is rakta’s relationship with blood? Rakta is a dhatu, or a flowing tissue that is responsible for the sustenance of life. Unlike what has been written in various commentaries or texts on rakta, blood is not the same as raktadhatu. Blood contains formed elements (RBC, WBC, platelets) which are products of sarakta meda, the integral component of majjadhatu. It has plasma containing minerals, vitamins, procoagulant and anticoagulant factors, enzymes, hormones, neurotransmitters, nutrients, etc., which are mostly assigned to rasadhatu. Blood also contains fats, cholesterol, free fatty acids etc., which are products of medadhatu. It contains blood proteins such as actin, myosin, myoglobin, etc. which are integral components of mamsadhatu. It also contains metabolic wastes such as urea and lactic acid etc., which are mala. Therefore, raktadhatu is a component of blood, using it as part of its material structure for its functions.
Blood is a balanced fluid that will not cause disease on its own, since its job is to give life. Rakta is a dhatu with the functions of jeevana, carriage, transformation, and the role of traveling through the arterial system, providing building blocks for creation and sustenance of the organs in the koshtha. Indeed, it was rakta that helped create them in the embryonic state. Prolonged consumption of pitta provoking diet and lifestyle vitiate rakta/blood. When the rakta/blood is vitiated, then it becomes an incompatible substance to the body. The body tries to clear it by expelling it in the form of bleeding.
The rakta, containing this contaminated pitta dosha provoking it, becomes increased in volume, and continues to circulate through the body, disturbing and dominating over all the functions of the rakta tissue. This rakta-pitta then blocks, coats, and vitiates the blood and the organs that rakta produces and nourishes. In raktapitta, the disease requires recognition early in its course to provide a person a cure, as manifestation of actual symptoms indicates end-stage.
Nutritional research claims on substances linked to hypo-coagulation and/or bleeding disorders
Much of the research on dietary interactions with bleeding disorders comes from the interaction of foods with warfarin. Since 1951, warfarin has been used as an anticoagulant, effectively preventing the formation of blood clots in the blood vessels and their migration elsewhere in the body respectively. warfarin reduces the availability of the reduced form of Vitamin K1, a critical molecule in the coagulation cascade, affecting blood coagulation proteins prothrombin and factor VII. Warfarin inhibits the enzyme vitamin K epoxide reductase, which recycles Vitamin K1 from its oxidized form to a ready reduced form. The net effect is that coagulation is lessened. Foods with high vitamin K1 directly supply the vitamin to the body, bypassing the inhibition of warfarin; thus they reinitiate the coagulation pathway.
These foods include leafy vegetables such as spinach, cabbage and broccoli, darker varieties of lettuces, some radishes, and the herbs parsley, cilantro and dill.
Spices and herbs with high salicylate content block vitamin K and act as natural blood thinners. The food substances mentioned in the etiology are rich in salicylates.
Garlic (Rasona) is clearly-mentioned among the etiological factors of raktapitta (C.Ni. 2/4). Garlic contains nine different naturally-occurring anti-platelet compounds. It also acts as natural antibiotic that can kill intestinal bacteria, which manufacture vitamin K.
Omega-3 Fatty Acids
Fish oil is a rich source of omega–3 fatty acids. Omega-3-fatty acids help to thin the blood. Fish may therefore be a great food for people who are at risk of blood clots but too much consumption of omega-3 can be at risk of bleeding disorders. This fact was long back observed and reported in Ayurveda Ayurveda in Charak Samhita (Ni.2.4).
Charak describes a group of preparations containing alcohol under nidana (Ni.2.4) (etiological factors): sura, sauvira, shukta, badaramala. Ayurvedic classics warn against excessive use of alcohols in pitta-vitiated patients, due to their heating and drying. In addition, biomedical research in 1986, suggests that subclinical vitamin K deficiency occurs in alcoholics, contributing to hypo-coagulability.
In summary, it appears that all the foods listed, either due to inherent veerya (heat dosha transfer potential) or combinations that create difficulty to digest using the body’s own heat, will raise a level of heat in the body that aggravates pitta dosha and initiates the cascade of pittakopa that leads eventually, if un-intervened, to raktapitta.
Among the lifestyle factors that lead down to aggravated pitta (viharaja nidanas) and raktapitta are excessive exercise(vyayama), and exposure to sunlight. Scientific evidence has now established that vigorous exercise appears to lower vitamin K levels and thus thin the blood. Sunlight increases the conversion of Vitamin D to Vitamin D3 in the skin; a recent clinical trial of a biologically active metabolite of Vitamin D3 demonstrated an unanticipated reduction of thrombosis in cancer patients. Therefore, it appears that Vitamin D3 reduces blood clotting.
Some bleeding disorders are known as hereditary or acquired through genetic transmission. Ayurveda Ayurveda seems to point to specific foods and habits that promote the manifestation of acquired bleeding disorders; one could propose an epigenetic mechanism to explain these disorders that have eventual onset. Bleeding disorders such as hemophilia that occur from birth, indeed all hereditary imperfections, are explained in Ayurveda Ayurveda with the concept of beeja dosha, or inheritance of paapam through cycles of karma.
Some pharmaceutical medications promote bleeding disorders. These situations can be treated by avoiding the etiological factors listed in this chapter. Once bleeding begins, the disease can be treated by removing the medicine, giving the patient sources of strong healthy pitta dosha, and fortifying the rakta so that organs fed by rakta can remain as healthy as possible.
Pathophysiology of Bleeding/Hemorrhagic Disorders in modern medicine
Per biomedicine, bleeding disorders are a group of heterogenous conditions that occur when the blood cannot clot properly. In normal clotting, platelets stick together when prompted by a stimulus that invokes the clotting pathway to ultimately form a plug at the site of an injured blood vessel. Proteins in the blood (clotting factors) are activated when either a pathogen or an exposed cell wall signal rupture of the blood vessel. An interactive cascade then leads to the formation of a fibrin clot, which holds the platelets in place and allows repair to occur at the site of the injury while preventing blood from escaping the blood vessel. While too much clotting can create either a thrombus or embolus that may lead to a heart attack and stroke, the inability to form clots can be very dangerous as well, as excess bleeding will also interrupt the integrity of the vascular system.
Many bleeding disorders are considered to be hereditary. Hemophilia, affecting mostly males, is perhaps the most well-known bleeding disorder, although it is relatively rare (affecting about 1 in 5,000 people worldwide). Many more people are affected by von Willebrand disease (VWD), the most common bleeding disorder in the USA. von Willebrand disease can affect both males and females.
Normal coagulation pathophysiology is described according to its major components:
- Vessel wall
- Platelet function
- Coagulation pathway
- Clot inhibition/lysis
I. Hemorrhagic Disorder Classifications
Hemorrhagic disorders can also occur from functional abnormalities of the vascular wall and are classified as:
- Hereditary: hereditary hemorrhagic telangiectasia, hereditary disorders of connective tissue such as Ehlers-Danlos syndrome
- Secondary: infections, chemical factors or drugs, disorders of metabolism (Vitamin C or K deficiency), pathological changes of vascular wall (atherosclerosis), connective tissue diseases
- Allergy: allergic purpura
- Other purpuras: purpura simplex, senile purpura, mechanic purpura, paraproteinemia
II. Platelet abnormalities
- Diminished or defective platelet production: aplastic anemia, marrow infiltration (carcinoma, leukemia, myelofibrosis, tuberculosis, etc), infections, drugs that act on platelet production (alcohol, thiazide diuretics).
- Enhanced platelet destruction: idiopathic thrombocytopenic purpura, drug-induced, thrombotic thrombocytopenic purpura. ##Sequestration of platelets: hypersplenism
- Primary: essential thrombocythemia.
- Secondary: infections, injury, post-splenectomy chronic myelocytic leukemia, other myeloproliferative disorders (such as polycythemia vera)
- Functional abnormalities of platelets:
- Congenital: thrombasthenia, giant platelet syndrome (Bernard-Soulier syndrome).
- Acquired: due to drugs, uremia, liver diseases, dysproteinemias
III. Coagulation disorders due to coagulation factor deficiencies
- Congenital: hemophilia A (F VIII deficiency), hemophilia B (F IX deficiency),factor XI deficiency (formerly hemophilia C), hypothrombinogenemia, hypofibrinogenemia, von Willebrand’s disease, other coagulation factors deficiency, including deficiency of activatedprotein C inhibitor structural abnormalities
- Acquired: Vitamin K deficiency, severe liver diseases, drugs (dicumarol), disseminated intravascular coagulation (DIC) etc
- Primary: Congenital deficiency of α2 antiplasmin, clinical use of urokinase, liver diseases, liberation of tissue plasminogen activator into the circulation
- Secondary: DIC
Causes of Bleeding
When normal hemostatic mechanisms fail, major hemorrhage may follow minor trauma or may appear to arise spontaneously. Biomedicine observes spontaneous bleeding primarily from either the rectum or from the naso-pharyngeal cavity.
A.Causes of bleeding from the mouth
- Common causes of bleeding from the mouth include:
- Dental caries, due to decay from chronic bacteria
- Trauma, due to mechanical injury
- Periodontal diseases, due to tissue decay from infectious origin, metabolic diseases or nutritional deficiencies
- Rare causes of bleeding from the mouth include:
- Viral hemorrhagic fevers
- Iatrogenic procedures such as crown placement, dental cleaning, placement and use of dentures, plaque removal, root canal, post tonsillectomy bleeding, and tooth extraction
- Other causes of bleeding from the mouth include:
- Bleeding diathesis
- Carcinoma, squamous cell of head and neck
- Idiopathic thrombocytopenic purpura
- Tonsillar abscess
B.Causes of Rectal Bleeding
Rectal bleeding, known medically as hematochezia, refers to the passage of red blood through the anus, often mixed with stool and/or blood clots. Rectal bleeding occurs from the tissues adjoining the anus. Blood in the stool does not always originate from the rectum but can come from any part of the gastro-intestinal tract. In fact, the color of the blood in the stool signifies its origin and could be red, maroon, brown, or black. The blood may also be invisible to the naked eye and only appear in the stool under microscopic investigation (thus it is called occult blood). When the blood passes through the zone of digestion in the duodenum, enzymes denature the hemoglobin changing its color from red to brown. When the blood passes through both the stomach’s intense acidic environment into the duodenum’s alkaline enzymes, the denaturing process renders it black by the time it exits from the rectum. Some of the common causes of rectal bleeding include anal fissure, hemorrhoids, diverticulosis, colon cancer and polyps, post-polypectomy, angiodysplasias, colitis, proctitis, and Meckel's diverticula. Rectal bleeding originating in the colon generally appears red in color. The origin of rectal bleeding is determined by history and physical examination, including tests such as anoscopy, flexible sigmoidoscopy, colonoscopy, radionuclide scans, visceral angiograms, and blood tests. The severity of rectal bleeding, determined by the quantity of blood passed, varies widely. Most blood in the stool or rectal bleeding is mild and self-limited. Many patients report only passing a few drops of fresh blood that turns the toilet water pink or observing spots of blood on toilet paper. Others may report brief passage of a spoonful or two of blood.
Bleeding may be moderate or severe. Patients with moderate bleeding will repeatedly pass larger quantities of bright or dark red (maroon-colored) blood often mixed with stools and/or blood clots. Patients with severe bleeding may either suffer from multiple bowel movements in a day or a single bowel movement containing a large amount of blood. Moderate or severe rectal bleeding can exhibit typical symptoms of anemia - weakness, dizziness, near-fainting or fainting, signs of low blood pressure or orthostatic hypotension, or a significant drop in blood pressure when going from a sitting or lying position to a standing position. In rare cases, the bleeding may be so severe that the body exhibits symptoms of shock due to excessive loss of blood. Moderate or severe rectal bleeding must be evaluated and treated in the hospital and may require the patient to undergo emergency hospitalization and transfusion of blood. Rectal bleeding is treated by correcting the resulting low blood volume and anemia, by determining the site and cause of blood loss, by stopping the bleeding, and by preventing relapse in bleeding.
Correlation between Ayurvedic knowledge and Western medicine
Biomedical textbooks rarely discuss the pathophysiology of bleeding disorders in terms of diet or nutrition, unlike Ayurveda. There is, therefore, a need to research the correlation between food articles and bleeding disorders. The following food substances are etiological factors of raktapitta, since these seem to act as blood thinners and can cause bleeding disorders in predisposed patients: (C.Ni. 2/4)
- Mulaka (Raphanus sativus Linn.), radish, Brassicaceae family
- Sarshapa (Brassica compestris Var.), Brassica rapa - turnip, napa cabbage, canola,
- Lashuna (Allium sativum Linn.), garlic
- Sumukha (Ocimum sp),
- Kutheraka (Ocimum sp.)
Also, the pathogenesis of blood disorders do not mention why a body would be predisposed to vessel wall problems, platelet dysfunctions, or clot inhibitions. Bleeding from different orifices of the body is not correlated with pathophysiology in biomedicine. Ayurveda however discusses raktapitta as an endpoint to a series of imbalancing events, and separates the discussion of diagnosis in Nidana Sthana from the discussion of treatment in Chikitsa Sthana.
Internal hemorrhage/hemorrhagic disorders of conventional medicine are well described in Ayurvedic texts in the form of raktapitta disorders, and the pathogenesis of raktapitta diseases forms the basis of this chapter. Raktapitta bleeding occurs through bodily orifices (mouth, rectum, urethra, nose, eye, ear, vagina, as well as hair-roots), per Ayurveda. The parallels between the description of bleeding disorders in conventional medicine and Ayurveda are quite apparent in this regard. An important aspect of the discussion on raktapitta disorders is the fact that some disorders are curable, some palliable and some are incurable – and that all these variants are dependent on doshic imbalances beyond just the pitta vitiation. It is important to note here that if proper attention is not paid, even curable disorders can soon aggravate to incurable variants. Avoidance of known causative factors is certainly one of the best measures to overcome this disease. Attempts need to be made to collect data on the effect of these factors (known to Ayurveda) and establish an empirical, evidence-based relationship between food articles (some of the primary etiological factors) and bleeding disorders.