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→Majja dhatu
It is one of the main ''dushyas'' (vitiating factors) described by Charaka in regards to ''prameha''. He narrated it especially in ''kaphaja prameha'' and ''avaranjanya madhumeha''. ''Mamsa'' and ''Kapha'' possess similar qualities and both give strength to the body. When vitiated, ''mamsa'' loses its normal consistency and develops ''shaithilya'' and provide space in between for the accumulation of morbid matter. That in turn results in ''putimamsa pidika'' (Ca.Ni. 4/8). ''Mamsa dushti'' can be compared to deranged protein metabolism which is an integral part of diabetes mellitus. Research studies have found that glucocorticoid activities and acidosis stimulates protein and amino acid catabolism . Amino acids breakdown in liver results in increased production of urea and these free amino acids can be compared with ''abaddha mamsa''. ''Putimamsa'' and ''pidaka'' are the morbid states of ''mamsa dhatu''. Two major changes take place in ''mamsa dhatu'' - protein degradation and reduction in its blood supply, both of which along with elevated blood sugar level form a favorable media for the growth and multiplication of microorganisms. The results are putrefaction and evolution of multiple septic foci in ''mamsa dhatu''. Diminished protein synthesis hampers the healing process and these complications adopt chronic course.
It is one of the main ''dushyas'' (vitiating factors) described by Charaka in regards to ''prameha''. He narrated it especially in ''kaphaja prameha'' and ''avaranjanya madhumeha''. ''Mamsa'' and ''Kapha'' possess similar qualities and both give strength to the body. When vitiated, ''mamsa'' loses its normal consistency and develops ''shaithilya'' and provide space in between for the accumulation of morbid matter. That in turn results in ''putimamsa pidika'' (Ca.Ni. 4/8). ''Mamsa dushti'' can be compared to deranged protein metabolism which is an integral part of diabetes mellitus. Research studies have found that glucocorticoid activities and acidosis stimulates protein and amino acid catabolism . Amino acids breakdown in liver results in increased production of urea and these free amino acids can be compared with ''abaddha mamsa''. ''Putimamsa'' and ''pidaka'' are the morbid states of ''mamsa dhatu''. Two major changes take place in ''mamsa dhatu'' - protein degradation and reduction in its blood supply, both of which along with elevated blood sugar level form a favorable media for the growth and multiplication of microorganisms. The results are putrefaction and evolution of multiple septic foci in ''mamsa dhatu''. Diminished protein synthesis hampers the healing process and these complications adopt chronic course.
==== ''Majja dhatu'' ====
===== ''Majjadhatu'' =====
''Majja dhatu'' is not vitiated to maximum extent but ''vata'' causes its ''kshaya'' i.e. depletion. Thus vitiated ''majja'' produces symptoms like ''netragaurava'' (heaviness in eyes), ''angagaurava''(heaviness in body) in patient of ''madhumeha''. The ketone bodies production due to excessive utilization of fat may be referred to ''dushti'' of ''vasa'' and ''majja''. ''Murchcha'' (temporary loss of consciousness) occurs due to dushti of ''majja'' in diabetes mellitus. The condition of hyperglycemic coma is characterized by the accumulation of ketone bodies.
''Majja dhatu'' is not vitiated to maximum extent but ''vata'' causes its ''kshaya'' i.e. depletion. Thus vitiated ''majja'' produces symptoms like ''netragaurava'' (heaviness in eyes), ''angagaurava''(heaviness in body) in patient of ''madhumeha''. The ketone bodies production due to excessive utilization of fat may be referred to ''dushti'' of ''vasa'' and ''majja''. ''Murchcha'' (temporary loss of consciousness) occurs due to dushti of ''majja'' in diabetes mellitus. The condition of hyperglycemic coma is characterized by the accumulation of ketone bodies.