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==Importance of concept in diagnosis:==
 
==Importance of concept in diagnosis:==
Dhatu have their respective srotasa (systems). These srotasa get affected due to vitiation of dosha and lead to diseases. Thus, dhatu are the site of lesion in view of diagnosis and target receptors in view of treatment. The increase or decrease of dhatu is also assessed for diagnosis of specific disease. The vitiated dosha reside in dhatu and produce specific clinical features as observed in conditions of jwara and kushtha.  
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Dhatu have their respective srotas (systems). These srotas get affected due to vitiation of dosha and lead to diseases. Thus, dhatu are the site of lesion in view of diagnosis and target receptors in view of treatment.  
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The increase or decrease of dhatu is also assessed for diagnosis of specific disease. The vitiated dosha reside in dhatu and produce specific clinical features as observed in conditions of jwara and kushtha.  
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In view of prognosis, involvement of a particular dhatu has importance in prognosis also.
 
In view of prognosis, involvement of a particular dhatu has importance in prognosis also.
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In jwara, if doshas are located in rasa, rakta, mamsa and medas dhatu, the conditionsare curable; while if those are located in the asthi and majja dhatu, then conditions are difficult to treat. If vitiated doshaare located in shukra dhatu, the condition isincurable. [Cha.Sa. Chikitsasthana 3/75-83]
 
In jwara, if doshas are located in rasa, rakta, mamsa and medas dhatu, the conditionsare curable; while if those are located in the asthi and majja dhatu, then conditions are difficult to treat. If vitiated doshaare located in shukra dhatu, the condition isincurable. [Cha.Sa. Chikitsasthana 3/75-83]
In the pathogenesis of prameha(obstinate urinary disorders) dosha ( kapha, pitta and vat,) along with  the ten factors called dushya i.e, medas, rakta, shukra, ambu (body fluid), vasa (muscle fat), lasika (lymph), majja, rasa, ojas  and mamsa  play the role.[Cha.Sa. Chikitsasthana 6/8]
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While considering the prognosis, “Tulyadushyata” (similarity between the characteristics of dosha and dushya) is a good sign of prognosis[Ashtanga Sangraha Sutra Sthana7/218]
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In the pathogenesis of prameha(obstinate urinary disorders) dosha ( kapha, pitta and vata,) along with  the ten factors called dushya i.e, medas, rakta, shukra, ambu (body fluid), vasa (muscle fat), lasika (lymph), majja, rasa, ojas  and mamsa  play the role.[Cha.Sa. Chikitsasthana 6/8].While considering the prognosis, “Tulyadushyata” (similarity between the characteristics of dosha and dushya) is a good sign of prognosis[Ashtanga Sangraha Sutra Sthana7/218]
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Pathology of kushtha(skin diseases) is related to deranged physiology of seven factors. They are vata, pitta and kapha doshas in aggravated state and dhatus, namely, tvak (since the skin is the organ in which rasa dhatu is present, tvak word is used instead of rasa dhatu), mamsa, shonita and lasika that get deranged due to aggravated dosha. Involvement of higher dhatu makes the disease more complicated. [Cha.Sa. Chikitsasthana 7/9-10]
 
Pathology of kushtha(skin diseases) is related to deranged physiology of seven factors. They are vata, pitta and kapha doshas in aggravated state and dhatus, namely, tvak (since the skin is the organ in which rasa dhatu is present, tvak word is used instead of rasa dhatu), mamsa, shonita and lasika that get deranged due to aggravated dosha. Involvement of higher dhatu makes the disease more complicated. [Cha.Sa. Chikitsasthana 7/9-10]
Visarpa (acute spreading erysepelas)also hasinvolvement of seven dhatu which determine the prognosis of the condition. [Cha.Sa. Chikitsasthana 21/12]
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Visarpa (acute spreading erysepelas)also has involvement of seven dhatu which determine the prognosis of the condition. [Cha.Sa. Chikitsasthana 21/12]
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According to Acharya Sushruta, visha(poison) situated in a particular dhatu produces the dhatupradoshajavikara of that particular dhatu.[Su.sa. Kalpasthana 2/30]
 
According to Acharya Sushruta, visha(poison) situated in a particular dhatu produces the dhatupradoshajavikara of that particular dhatu.[Su.sa. Kalpasthana 2/30]
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Dhatukshaya (degeneration of tissues):  
 
Dhatukshaya (degeneration of tissues):  
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Dhatukshaya means degeneration or decrement of quality and/or quality of body tissues. It is considered an important event in many disease pathologies.  
 
Dhatukshaya means degeneration or decrement of quality and/or quality of body tissues. It is considered an important event in many disease pathologies.  
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In Rajayakshma (wasting diseases) there is direct relationship to the defect in nourishment of body tissues. The diagnosis and treatment depend upon qualitative and quantitative assessment of dhatu. [Cha.Sa. Nidanasthana 6/ 8-9]
 
In Rajayakshma (wasting diseases) there is direct relationship to the defect in nourishment of body tissues. The diagnosis and treatment depend upon qualitative and quantitative assessment of dhatu. [Cha.Sa. Nidanasthana 6/ 8-9]
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Moreover, dhatukshaya is mentioned as the etiology or consequence of different diseases like
 
Moreover, dhatukshaya is mentioned as the etiology or consequence of different diseases like
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• Unmada[Cha.Sa. Chikitsasthana 9/9]
 
• Unmada[Cha.Sa. Chikitsasthana 9/9]
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• Udara[Cha.Sa. Chikitsasthana 13/194]
 
• Udara[Cha.Sa. Chikitsasthana 13/194]
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• Pandu [Cha.Sa. Chikitsasthana 16/5]
 
• Pandu [Cha.Sa. Chikitsasthana 16/5]
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• Hikka, Shwasa[Cha.Sa. Chikitsasthana 17/82]
 
• Hikka, Shwasa[Cha.Sa. Chikitsasthana 17/82]
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• Kasa[Cha.Sa. Chikitsasthana 18/153]
 
• Kasa[Cha.Sa. Chikitsasthana 18/153]
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• Chhardi[Cha.Sa. Chikitsasthana 20/46]
 
• Chhardi[Cha.Sa. Chikitsasthana 20/46]
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• Trushna[Cha.Sa. Chikitsasthana 22/5]
 
• Trushna[Cha.Sa. Chikitsasthana 22/5]
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• Vatavyadhi [Cha.Sa. Chikitsasthana 28/59]
 
• Vatavyadhi [Cha.Sa. Chikitsasthana 28/59]
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• Klaibya [Cha.Sa. Chikitsasthana 30/180]
 
• Klaibya [Cha.Sa. Chikitsasthana 30/180]
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• Marmabhighata- in Kalantarapranahara and VaikalyakaraMarma[Su.Sa. Sharirasthana 6/37-38]
 
• Marmabhighata- in Kalantarapranahara and VaikalyakaraMarma[Su.Sa. Sharirasthana 6/37-38]
  
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