Changes

===Body constitution or phenotype ([[deha prakriti]])===

===Body constitution or phenotype ([[deha prakriti]])===

The body constitution ([[prakriti]]) of a person is based upon the relative proportions of the three dosha. The equilibrium or dominance of dosha at the time of formation of embryo determines the body constitution ([[deha prakriti]]). [Cha.Sa. [[Sutra Sthana]] 7/40] This proportion is further modulated by the diet and lifestyle of mother, age, and the environment in which the person grows to generate the unique dosha-prakriti of the individual.  The individual shows characteristic features of respective dominant dosha in [[prakriti]]. It is very similar to the phenotype in modern biology. Thus, the current genetic paradigms believe that the phenotype of individual results from interaction between genotype (established at fertilization) and the environment, which includes epigenetic changes resulting from parental age, diet, lifestyle, and other environmental factors.<ref>Lakhotia S. C. (2014). Translating Ayurveda's Dosha-Prakriti into objective parameters. Journal of Ayurveda and integrative medicine, 5(3), 176.</ref>  Genomic variations with the classification of [[prakriti]] are studied. It is observed that PGM1 correlates with phenotype of [[pitta prakriti]]. This suggests that the phenotypic classification has a genetic basis; and its [[prakriti]]-based practice resonates with personalized medicine.<ref>Govindaraj, P. et al. Genome-wide analysis correlates Ayurveda Prakriti. Sci. Rep. 5, 15786; doi: 10.1038/srep15786 (2015)</ref>  The relation between clinical phenotype and predisposition of disease is studied. The study was carried out on the association of Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C with type 2 diabetes and prakriti. An extremely strong association between prakriti (kaphaja/kapha-pittaja) and type 2 diabetes (P < 0.00001) was detected in this study.<ref>Gupta A, Ali A, Tewari P, Agrawal NK, Patel R, Byadgi PS. Association of kaphaja and kapha-pittaja prakriti and methylenetetrahydrofolate reductase C677T allele with type 2 diabetes. AYU [serial online] 2018 [cited 2020 Jan 5];39:146-50. Available from: http://www.ayujournal.org/text.asp?2018/39/3/146/255251</ref>

The body constitution ([[prakriti]]) of a person is based upon the relative proportions of the three dosha. The equilibrium or dominance of dosha at the time of formation of embryo determines the body constitution ([[deha prakriti]]). [Cha.Sa. [[Sutra Sthana]] 7/40] This proportion is further modulated by the diet and lifestyle of mother, age, and the environment in which the person grows to generate the unique dosha-prakriti of the individual.  The individual shows characteristic features of respective dominant dosha in [[prakriti]]. It is very similar to the phenotype in modern biology. Thus, the current genetic paradigms believe that the phenotype of individual results from interaction between genotype (established at fertilization) and the environment, which includes epigenetic changes resulting from parental age, diet, lifestyle, and other environmental factors.<ref>Lakhotia S. C. (2014). Translating Ayurveda's Dosha-Prakriti into objective parameters. Journal of Ayurveda and integrative medicine, 5(3), 176.</ref>  Genomic variations with the classification of [[prakriti]] are studied. It is observed that PGM1 correlates with phenotype of [[pitta]] [[prakriti]]. This suggests that the phenotypic classification has a genetic basis; and its [[prakriti]]-based practice resonates with personalized medicine.<ref>Govindaraj, P. et al. Genome-wide analysis correlates Ayurveda Prakriti. Sci. Rep. 5, 15786; doi: 10.1038/srep15786 (2015)</ref>  The relation between clinical phenotype and predisposition of disease is studied. The study was carried out on the association of Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C with type 2 diabetes and prakriti. An extremely strong association between [[prakriti]] (kaphaja/kapha-pittaja) and type 2 diabetes (P < 0.00001) was detected in this study.<ref>Gupta A, Ali A, Tewari P, Agrawal NK, Patel R, Byadgi PS. Association of kaphaja and kapha-pittaja prakriti and methylenetetrahydrofolate reductase C677T allele with type 2 diabetes. AYU [serial online] 2018 [cited 2020 Jan 5];39:146-50. Available from: http://www.ayujournal.org/text.asp?2018/39/3/146/255251</ref>

   

   

Studies have shown that Ayurvedic body type classification may be associated with genes of inflammation and oxidative stress factors, the rate of DNA methylation and development of cardiovascular diseases.<ref>Anna Korossy, Anna Blazovics. Ayurveda for the treatment of Obesity. Orv Hetil 2016 Aug; 157 (34):1349-52. DOI: 10.1556/650.2016.30534.</ref>

Studies have shown that Ayurvedic body type classification may be associated with genes of inflammation and oxidative stress factors, the rate of DNA methylation and development of cardiovascular diseases.<ref>Anna Korossy, Anna Blazovics. Ayurveda for the treatment of Obesity. Orv Hetil 2016 Aug; 157 (34):1349-52. DOI: 10.1556/650.2016.30534.</ref>

===Influence of dosha on digestion ([[agni]]) and gut ([[koshtha]])===

===Influence of dosha on digestion ([[agni]]) and gut ([[koshtha]])===