Changes

#''Bhojanamadhya'' (in the midst of lunch) e.g. water or any liquids  

#''Bhojanamadhya'' (in the midst of lunch) e.g. water or any liquids  

#''Bhojanante'' (at the end of lunch) e.g. ''lavanga'' (clove) and fruits of ''haritaki'' (Chebulic myrobalans)

#''Bhojanante'' (at the end of lunch) e.g. ''lavanga'' (clove) and fruits of ''haritaki'' (Chebulic myrobalans)

#''Bhojanapurvante'' (before and after lunch) e.g. ''dhatriloha'': a formulation made of ''dhatri'' (Emblica officinalis) and ''loha'' (iron) ''bhasma'' prescribed in ''amlapitta'' (acid peptic disease).  [299]

#''Bhojanapurvante'' (before and after lunch) e.g. ''dhatriloha'': a formulation made of ''dhatri'' (Emblica officinalis) and ''loha'' (iron) ''bhasma'' prescribed in ''amlapitta'' (acid peptic disease).<ref>Dr.S.S.Sawrikar, ''Sharangdhar Samhita, Pre-published English Translation and Discussion'' </ref> [299]

The time of drug administration which is related to the type of disease and status of the ''doshas'' in the body can be called as chronotherapeutics. Chronotherapeutics refers to a treatment method in which in-vivo drug availability is timed to match rhythms of disease in order to optimize therapeutic outcomes and minimize side effects. It is based on the observation that there is an interdependent relationship between the peak-to-trough rhythmic activity in disease symptoms and risk factors, pharmacologic sensitivity, and pharmacokinetics of many drugs.

The time of drug administration which is related to the type of disease and status of the ''doshas'' in the body can be called as chronotherapeutics. Chronotherapeutics refers to a treatment method in which in-vivo drug availability is timed to match rhythms of disease in order to optimize therapeutic outcomes and minimize side effects. It is based on the observation that there is an interdependent relationship between the peak-to-trough rhythmic activity in disease symptoms and risk factors, pharmacologic sensitivity, and pharmacokinetics of many drugs.