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|title=Trividhakukshiya Vimana

|title=Trividhakukshiya Vimana

|titlemode=append

|titlemode=append

|keywords=Kukshi, capacity of stomach, digestion, quantity of food, diet, poor digestion, ama, visuchika, alasaka, Ayurveda, Indian system of medicine, charak samhita, satiety, factors affecting digestion.

|keywords=Kukshi, capacity of stomach, digestion, quantity of food, diet, poor digestion, ama, visuchika, alasaka, Ayurveda, Indian system of medicine, charak samhita, satiety, factors affecting digestion, non infectious gastroenteritis, sluggish bowel.

|description=Vimana Sthana Chapter 2. Three parts of abdomen and principles of diet

|description=Vimana Sthana Chapter 2. Three parts of abdomen and principles of diet

|image=http://www.carakasamhitaonline.com/mediawiki-1.32.1/resources/assets/ogimgs.jpg

|image=http://www.carakasamhitaonline.com/mediawiki-1.32.1/resources/assets/ogimgs.jpg

<div style="text-align:justify;">This chapter describes the principles of food and dietary intake for healthy living with special emphasis on the quantum of food ingested. It is advised that one must eat in accordance with the capacity of one’s stomach and the quantity of food is determined by the strength of one’s digestion capacity ([[agni]]). [[Ayurveda]] regards [[ama]], or undigested food, as the cause of vitiation of [[dosha]] and consequently various disorders. Proper quantity of food is digested in time without disturbing one’s health. Diet taken with proper consideration of [[agni]] positively promotes one’s strength, complexion, health and life, while improper quantity (amatra) of food - less (heena) or excess (adhika) - leads to various disorders. The chapter mentions  various aspects of satiety and its physioloigcal mechanisms.  </div>

<div style="text-align:justify;">This chapter describes the principles of food and dietary intake for healthy living with special emphasis on the quantum of food ingested. It is advised that one must eat in accordance with the capacity of one’s stomach and the quantity of food is determined by the strength of one’s digestion capacity ([[agni]]). [[Ayurveda]] regards [[ama]], or undigested food, as the cause of vitiation of [[dosha]] and consequently various disorders. Proper quantity of food is digested in time without disturbing one’s health. Diet taken with proper consideration of [[agni]] positively promotes one’s strength, complexion, health and life, while improper quantity (amatra) of food - less (heena) or excess (adhika) - leads to various disorders. The chapter mentions  various aspects of satiety and its physioloigcal mechanisms.  </div>

'''Keywords:''' ''Kukshi'', capacity of stomach, digestion, quantity of food, diet, poor digestion, [[ama]], [[visuchika]], [[alasaka]], satiety, indigestion.

'''Keywords:''' ''Kukshi'', capacity of stomach, digestion, quantity of food, diet, poor digestion, [[ama]], [[visuchika]], [[alasaka]], satiety, indigestion, non infectious gastroenteritis, sluggish bowel.

== Introduction ==

== Introduction ==

Food taken in excessive quantities aggravates all [[dosha]] and produces symptoms characteristic of each of the vitiated [[dosha]] separately.  In addition to the quantity of food, untimely intake and the quality of food, i.e., intake of heavy, unctuous, cold, unclean and mutually contradictory food are responsible for the formation and vitiation of [[ama]]. Wholesome food, even if taken in proper quantity does not get properly digested if the individual is afflicted with anxiety, fear, grief, envy, anger, greed etc. and other such negative emotional states. These causative factors lead to formation of [[ama]].  

Food taken in excessive quantities aggravates all [[dosha]] and produces symptoms characteristic of each of the vitiated [[dosha]] separately.  In addition to the quantity of food, untimely intake and the quality of food, i.e., intake of heavy, unctuous, cold, unclean and mutually contradictory food are responsible for the formation and vitiation of [[ama]]. Wholesome food, even if taken in proper quantity does not get properly digested if the individual is afflicted with anxiety, fear, grief, envy, anger, greed etc. and other such negative emotional states. These causative factors lead to formation of [[ama]].  

[[Ama]] is the undigested food material which remains inside body and  produces toxic effects. The clinical presentation of [[ama]] has two variations-[[visuchika]] (diarrhea and vomiting) and [[alasaka]](sluggish bowels) - with primarily gastrointestinal and few systemic features. The line of management of [[ama]] includes emesis, fomentation, use of suppositories, and fasting followed by the use of [[deepana]] and [[pachana]] class of drugs. The patients should be given massage, [[asthapana]] and [[anuvasana]] types of [[basti]] and also oleation therapy after the patient is free from [[ama]], helping restore the patient’s lost strength.

[[Ama]] is the undigested food material which remains inside body and  produces toxic effects. The clinical presentation of [[ama]] has two variations-[[visuchika]] (non infectious gastroenteritis) and [[alasaka]](sluggish bowels) - with primarily gastrointestinal and few systemic features. The line of management of [[ama]] includes emesis, fomentation, use of suppositories, and fasting followed by the use of [[deepana]] and [[pachana]] class of drugs. The patients should be given massage, [[asthapana]] and [[anuvasana]] types of [[basti]] and also oleation therapy after the patient is free from [[ama]], helping restore the patient’s lost strength.

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==Sanskrit Text, Transliteration and English Translation==               

==Sanskrit Text, Transliteration and English Translation==               

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Physicians describe two types of diseases caused by [[ama]] [[dosha]] –[[visuchika]] (diarrhea and vomiting) and [[alasaka]] (sluggish bowels). [10]

Physicians describe two types of diseases caused by [[ama]] [[dosha]] –[[visuchika]] (non infectious gastroenteritis) and [[alasaka]] (sluggish bowels). [10]

==== [[Visuchika]](diarrhea and vomiting) ====

==== [[Visuchika]](non infectious gastroenteritis) ====

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The expulsion of ''ama dosha'' (undigested food) through both upper and lower passages of the gastrointestinal tract with the features already described above is [[Visuchika]] (diarrhea and vomiting).[11]

The expulsion of ''ama dosha'' (undigested food) through both upper and lower passages of the gastrointestinal tract with the features already described above is [[Visuchika]] (non infectious gastroenteritis).[11]

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==== [[Alasaka]](sluggish bowel) ====

==== [[Alasaka]](sluggish bowel) ====

* If food taken in the morning is digested by evening and food taken in the evening is digested by morning, it indicates that the correct quantity of food has been consumed. Excess or inadequate food causes malnourishment while optimum quantity of food causes nourishment. Food ingested in proper quantity produces effects on all biological systems including sense organs, strength and complexion. Assessment of proper digestion and metabolism can be done as per given signs.  

* If food taken in the morning is digested by evening and food taken in the evening is digested by morning, it indicates that the correct quantity of food has been consumed. Excess or inadequate food causes malnourishment while optimum quantity of food causes nourishment. Food ingested in proper quantity produces effects on all biological systems including sense organs, strength and complexion. Assessment of proper digestion and metabolism can be done as per given signs.  

* Positive mental status is important while ingesting food. The negative mental status while taking food can lead to improper digestion even if the food is in proper quantity.  

* Positive mental status is important while taking food. The negative mental status can lead to improper digestion, even if the food is in proper quantity.  

* The food that is heavy to digest, dry, cold, dehydrated, disliked by consumer, causing constipation and burning, unclean and incompatible causes disorders of [[ama]] such as [[visuchika]], [[alasaka]], and [[dandalasaka]] (indigestion, food poisoning, paralytic ileus).

* The food that is heavy to digest, dry, cold, dehydrated, disliked by consumer, causing constipation and burning, unclean and incompatible causes disorders of [[ama]] such as [[visuchika]], [[alasaka]], and [[dandalasaka]] (indigestion, food poisoning, paralytic ileus).

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A wholesome diet reserves the highest place for proper growth, development, and health maintenance in human life [Cha.Sa.[[Sutra Sthana]]25/31], [Chakrapani on Cha.Sa.[[Sutra Sthana]] 5/2]. The effect of food articles on body tissues primarily depends on eight factors (ashta aahara vidhi vishesha aayatana), including the quantity of food (rashi). The tetrad of chapters on health (Swastha chatushka) in [[sutra sthana]] aims preservation of health and prevention of diseases. It commences with a discussion on food (ahara) and importance of its proper quantity (matra). This indicates the utmost importance of the quantity of food for the maintenance of health [Cha.Sa.[[Sutra Sthana]] 5/3]. This chapter discusses the effect of food articles on body physiology concerning amount explicitly. It further explains [[dosha]] specific disorders with predominant involvement of [[dosha]] in manifestation of the disease; and negligible involvement of [[dushya]] ([[dhatu]] and [[mala]]).   

A wholesome diet reserves the highest place for proper growth, development, and health maintenance in human life [Cha.Sa.[[Sutra Sthana]]25/31], [Chakrapani on Cha.Sa.[[Sutra Sthana]] 5/2]. As described in previous chapter, the effect of food articles on body tissues primarily depends on eight factors (ashta aahara vidhi vishesha aayatana) like  nature of food ([[prakriti]]), preparation methods (karana), combination(samyoga), quantity(rashi), place(desha),  time (kala), rules for use(upayoga -samstha) and consumer(upayokta).[Cha.Sa. [[Vimana Sthana]] 1/21] The quantity of food (rashi) is emphasized in the tetrad of chapters on health (Swastha chatushka) in [[sutra sthana]] for preservation of health and prevention of diseases. [Cha.Sa.[[Sutra Sthana]] 5/3]. This chapter discusses the effect of food articles on body physiology concerning amount explicitly. It further explains [[dosha]] specific disorders with predominant involvement of [[dosha]] in manifestation of the disease; and negligible involvement of [[dushya]] ([[dhatu]] and [[mala]]).   

=== Assessment of food ingestion capacity (ahara shakti) ===

=== Importance of [[Agni]] (digestion and metabolism) in health ===

The food ingestion capacity (aahara shakti) of a person is assessed on two parameters:

The proper quantity of food depends on the strength of [[agni]] (factors responsible for digestion and metabolism). The strength of [[agni]] varies according to season, age and other factors. Thus the amount of food will also vary as per the power of [[agni]]. Suitable variation in quantity of food helps maintaining proper digestion and metabolism. The quantity further subjects to heavy to digest (gurutva) and light to digest (laghutva) nature of food. Nourishing benefits of diet is subjected to the status of [[agni]]. Thus [[agni]] is an important facilitator between health and food. Assessment of the status of [[agni]] is an essential component in maintenance of health as well as while treating diseased conditions.

==== Assessment of status of [[Agni]] ====

# Digestion capacity (jarana shakti) [Cha.Sa.[[Vimana Sthana]] 8/120]

The proper quantity of food depends on the strength of [[agni]] ( factors responsible for digestion and metabolism). The strength of [[agni]] varies according to season, age and other factors. Thus the amount of food will also vary as per the power of [[agni]]. The suitable variation in quantity of food helps maintaining proper digestion and metabolism. The quantity further subjects to heavy to digest (gurutva) and light to digest (laghutva) nature of food.

Depending on the predominance of afflicted [[dosha]], four types of digestive patterns ([[agni]]) are described:

 

#Samagni (Normal state of digestion and metabolism)

=== Assessment of [[Agni]] (digestion and metabolism) ===

#Vishamagni (irregular state of digestion and metabolism)

 

# Tikshagni (rapid or intense state of digestion and metabolism)  

Nourishing benefits of diet is subjected to the status of [[agni]].Thus [[agni]] is an important facilitator between health and food. Assessment of the status of [[agni]] is an essential component in maintenance of health as well as while treating diseased conditions. Singh A, Patwardhan K. et. al. developed and validated a self-assessment tool to estimate strength of [[agni]]. The study also evaluates the practical utility of developed tool by recording serum lipid parameters. Lipid parameters vary significantly according to the status of [agni]]. <ref>Singh A, Singh G,  Patwardhan K, Gehlot S. Development, Validation and Verification of a Self-Assessment Tool to Estimate Agnibala (Digestive Strength). J Evid Based Complementary Altern Med. 2017 Jan;22(1):134-140. doi: 10.1177/2156587216656117. Epub 2016 Jul 4.</ref>

# Mandagni (slow or weak state of digestion and metabolism).  

Eswaran H. T. et. al. prepared an [[agni]] assessment scale comprising 64 questions to evaluate the four types of [[agni]]. The study has validated a scale for internal consistency. <ref>Eswaran HT, Kavita MB, Tripaty TB, and Shivakumar. Formation and validation of questionnaire to assess Jāṭharāgni. Anc Sci Life.2015 Apr-Jun; 34(4): 203–209.</ref>

The first type of normal digestion (samagni) needs 12 hours (4 yama) for complete digestion of food, and 6 hours (2 yama) for proper digestion of medicine. [A.S. Sutra Sthana 11/53]  The time taken for complete digestion suggests digestive pattern of that individual.

Patil VC, Baghel MS et. al. developed formulae for assessment of the digestive functions ([[agni]]) during administration of [[snehana]] (internal oleation). <ref>Patil VC, Baghel MS, Thakar AB. Assessment of [[agni]] (digestive process) and [[koshtha]] (bowel movement with special reference to abhyantara [[snehana]] (internal oleation). Ancient Sci. Life. 2008; 28:26-28</ref>  

Eswaran H. T. et. al. prepared an [[agni]] assessment scale comprising 64 questions to evaluate the four types of [[agni]]. The study has validated a scale for internal consistency. <ref>Eswaran HT, Kavita MB, Tripaty TB, and Shivakumar. Formation and validation of questionnaire to assess Jāṭharāgni. Anc Sci Life.2015 Apr-Jun; 34(4): 203–209.</ref>  Singh A, Patwardhan K. et. al. developed and validated a self-assessment tool to estimate strength of [[agni]] by recording serum lipid parameters. <ref>Singh A, Singh G,  Patwardhan K, Gehlot S. Development, Validation and Verification of a Self-Assessment Tool to Estimate Agnibala (Digestive Strength). J Evid Based Complementary Altern Med. 2017 Jan;22(1):134-140. doi: 10.1177/2156587216656117. Epub 2016 Jul 4.</ref> Patil VC, Baghel MS et. al. developed formulae for assessment of the digestive functions ([[agni]]) during administration of [[snehana]] (internal oleation). <ref>Patil VC, Baghel MS, Thakar AB. Assessment of [[agni]] (digestive process) and [[koshtha]] (bowel movement with special reference to abhyantara [[snehana]] (internal oleation). Ancient Sci. Life. 2008; 28:26-28</ref> These tools are used to assess the status of [[agni]] and determine proper qunatity.

[[Agni]] performs various functions of digestion, metabolism and assimilation. Gastric secretions is a digestive fluid, formed in the stomach and contain numerous compounds including hydrochloric acid (HCL), pepsin, lipase, mucin. Kulatunga et al assessed the status of [[agni]] in the patients of [[pandu]] (anemia and blood deficiency disorders) and find out its relationship with the acidity of gastric secretions by use of fractional test meal examination. Their study concluded that HCL reduction in patients of anemia seriously affects the protein and iron absorption; thus Hypochlorhydria (found in 72.8% of the patients) indicates hypofunction of [[agni]].<ref>Kulatunga R D H, Rai N P, Ali Z. Status of Agni in Pandu Roga (anemia) and its association with the acidity of gastric secretions-A Clinical Study. IAMJ: Volume 7, Issue 1, January – 2019.</ref>

[[Agni]] performs various functions of digestion, metabolism and assimilation. Gastric secretions is a digestive fluid, formed in the stomach and contain numerous compounds including hydrochloric acid (HCL), pepsin, lipase, mucin. Kulatunga et al assessed the status of [[agni]] in the patients of [[pandu]] (anemia and blood deficiency disorders) and find out its relationship with the acidity of gastric secretions by use of fractional test meal examination. Their study concluded that HCL reduction in patients of anemia seriously affects the protein and iron absorption; thus Hypochlorhydria (found in 72.8% of the patients) indicates hypofunction of [[agni]]. <ref>Kulatunga R D H, Rai N P, Ali Z. Status of Agni in Pandu Roga (anemia) and its association with the acidity of gastric secretions-A Clinical Study. IAMJ: Volume 7, Issue 1, January – 2019.</ref> The fractional meal test examination is applied to study status of [[agni]] in relatio to disease formation.

=== Classification of food ===

=== Varieties of food for determining quantity ===

[[File: Fig 1 Extrinsic factors.jpg|500px|thumb|right|'''Fig.1: Extrinsic factors influencing quantity of food''']]

[[File: Fig 1 Extrinsic factors.jpg|500px|thumb|right|'''Fig.1: Extrinsic factors influencing quantity of food''']]

[[File: Fig 2 Intrinsic factors.jpg|500px|thumb|right|'''Fig.2: Intrinsic factors influencing quantity of food''']]

[[File: Fig 2 Intrinsic factors.jpg|500px|thumb|right|'''Fig.2: Intrinsic factors influencing quantity of food''']]

Depending on the consistency, the food articles are classified into four categories: drinkable, likable, eatable, and chewable. These four types are further abbreviated under two classes as liquid foods and solid foods respectively. Thus both type of food shall be consumed till half of it satiety or till feeling of satiety. This quantity will definitely be digested in due time, without disturbing [[dosha]] physiology ([[prakriti]]), thus indicates proper quantity (aahara matra). Subjective parameters shall be observed carefully to decide the proper quantity of food. [Cha. Sa.[[Vimana Sthana]] 2/6] Food consumed in the appropriate quantity enhances strength, complexion, and nourishment of tissues.

Depending on the consistency, the food articles are classified into various categories:  

There are other six types of food patterns described depending upon the consistency of food viz.  

# Lickables (lehya) e.g. rasala (curd mixed with sugar and spices) and kadhi (a traditional Indian dish consisting mainly of yogurt and gram floor)

# Hard eatables(bhakshya) e.g. laddu, modak (kind of sweet meal)

# Chewables (charvya) e.g. poha, roasted horse gram

# Suckables(chushya) e.g. sugarcane

# Suckables(chushya) e.g. sugarcane

These food articles are heavy for digestion in ascending order. [B.P. Prathama Khanda 4/142-143]<ref>Bhavamishra. Bhavaprakasha -Volume I. Translated from Sanskrit by K.R. Srikantha Murthy. 1st ed. Varanasi: Krishnadas academy;2000.</ref>

These food articles are heavy for digestion in ascending order. [B.P. Prathama Khanda 4/142-143] <ref>Bhavamishra. Bhavaprakasha -Volume I. Translated from Sanskrit by K.R. Srikantha Murthy. 1st ed. Varanasi: Krishnadas academy;2000.</ref> These types are further abbreviated under two major classes as liquid foods and solid foods. Both types of food shall be consumed till half of it satiety or till feeling of satiety. If consumed in proper qunatity, these are digested in due time, without disturbing [[dosha]] physiology ([[prakriti]]). Subjective parameters shall be observed carefully to decide the proper quantity of food. [Cha. Sa.[[Vimana Sthana]] 2/6] 

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==== [[Amashaya]]- Site of digestion ====

=== [[Amashaya]]- site of digestion ===

Amashaya is a site of digestion of all types of food. After complete digestion, the digested essence of food reaches all the body organs through vessels. Amashaya is a seat of [[pitta dosha]] and [[kapha dosha]] [Cha. Sa.[[Sutra Sthana]] 20/8] and the disorders originated from [[amashaya]] are specifically grouped as the disorders having a predominance of these two [[dosha]]. [Cha.Sa.[[Vimana Sthana]] 6/3] The Pachaka pitta and kledaka kapha play important role in digestion. Surface anatomy describes [[amashaya]] as the organ situated between the umbilicus and the breast. Stomach can be considered as upper segment of [[amashaya]]. Small intestine along with liver and pancreas can be considered as the lower segment of [[amashaya]].   

Amashaya is a site of digestion of all types of food. After complete digestion, the digested essence of food reaches all the body organs through vessels. Amashaya is a seat of [[pitta dosha]] and [[kapha dosha]] [Cha. Sa.[[Sutra Sthana]] 20/8] and the disorders originated from [[amashaya]] are specifically grouped as the disorders having a predominance of these two [[dosha]]. [Cha.Sa.[[Vimana Sthana]] 6/3] The Pachaka pitta and kledaka kapha play vital role in digestion. [[Amashaya]] is situated between the umbilicus and the breast as per surface anatomy. Stomach is considered as upper segment of [[amashaya]]. Small intestine along with liver and pancreas is considered as the lower segment of [[amashaya]].   

==== Proper quantity of food ====

=== Proper quantity of food ===

If a person has taken excellent quality food as per the eight specific dietary factors (ashta aahara vidhi vishesha ayatana) and followed all the rules while taking food ([[aahara vidhi]] vidhana), then the food is digested in due time without disturbing the equilibrium of [[dosha]] ([[prakriti]]), and that amount of food is termed as the "proper quantity of food for that person".

If a person has taken excellent quality food as per the eight specific dietary factors (ashta aahara vidhi vishesha ayatana) and followed all the rules while taking food ([[aahara vidhi]] vidhana), then the food is digested in due time without disturbing the equilibrium of [[dosha]] ([[prakriti]]), and that amount of food is termed as the "proper quantity of food for that person".

The extrinsic and intrinsic factors influencing quantity of food are shown in fig.1 and fig.2 respectively.

The extrinsic and intrinsic factors influencing quantity of food are shown in fig.1 and fig.2 respectively.

==== Role of satiety and three parts of ingestion capacity ====

==== Role of satiety and three parts of ingestion capacity ====

Satiety is one of the subjective parameters to assess the ingestion capacity of a person. The maximum ingestion capacity of a person should be divided into three parts. One-third part of food intake should be consumed in solid form and one third part as liquid diet, remaining one third part of total capacity should be kept empty for movement of [[vata]], [[pitta]] and [[kapha]]. This is the indicator of satiety. This means once the two third part of stomach will be filled, a person will have the feeling of satisfaction [Cha.Sa.[[Sutra Sthana]]25/40]. At this point the person should stop eating. If this limit is crossed, the excess food stuff will occupy the third part of stomach which interrupts the process of digestion, causing extra burden on [[agni]] (digestive power) and may result indigestion. The divisions of stomach (amashaya) are not in equal proportion, but it is in accordance with user’s suitability and the adaptive pattern of food consumption [Chakrapani on Cha.Sa.[[Vimana Sthana]]2/3]. Power of ingestion (abhyavaharana shakti) is different for every individual and it depends upon the strength of digestive capacity (jatharagni). The proper quantity of food (ahara matra) to be consumed is subjected to power of ingestion and consistency of food articles i.e. solid and liquid.

Satiety is one of the subjective parameters to assess the ingestion capacity of a person. The maximum ingestion capacity of a person should be divided into three parts. One-third part of food intake should be consumed in solid form and one third part as liquid diet, remaining one third part of total capacity should be kept empty for movement of [[vata]], [[pitta]] and [[kapha]]. This is the indicator of satiety. This means once the two third part of stomach will be filled, a person will have the feeling of satisfaction [Cha.Sa.[[Sutra Sthana]]25/40]. At this point the person should stop eating. If this limit is crossed, the excess food stuff will occupy the third part of stomach which interrupts the process of digestion, causing extra burden on [[agni]] (digestive power) and may result indigestion. The divisions of stomach (amashaya) are not in equal proportion, but it is in accordance with user’s suitability and the adaptive pattern of food consumption [Chakrapani on Cha.Sa.[[Vimana Sthana]]2/3]. Power of ingestion (abhyavaharana shakti) is different for every individual and it depends upon the strength of digestive capacity (jatharagni). The proper quantity of food (ahara matra) to be consumed is subjected to power of ingestion and consistency of food articles i.e. solid and liquid.

Some Ayurveda scholars have divided ingestion capacity of amashaya in four parts and advised to take two parts with solid food, one part with liquids and rest one fourth part to be left empty for [[dosha]] (as a normal physiology of digestion). [A.Hr.[[Sutra Sthana]]8/46-47]<ref name="A. Hridaya">Vagbhata. Ashtanga Hridayam. Edited by Harishastri Paradkar Vaidya. 1st ed. Varanasi: Krishnadas Academy;2000.</ref> Arundatta, commentator of Vagbhata has considered this capacity of [[amashaya]] as the measurement of satiety.

Some Ayurveda scholars have divided ingestion capacity of [[amashaya]] in four parts and advised to take two parts with solid food, one part with liquids and rest one fourth part to be left empty for [[dosha]] (as a normal physiology of digestion). [A.Hr.[[Sutra Sthana]]8/46-47]<ref name="A. Hridaya">Vagbhata. Ashtanga Hridayam. Edited by Harishastri Paradkar Vaidya. 1st ed. Varanasi: Krishnadas Academy;2000.</ref> Arundatta, commentator of Vagbhata has considered this capacity of [[amashaya]] as the measurement of satiety.

==== Understanding proper quantity of food (sauhitya matra) and physiological mechanism of satiation====

==== Physiological mechanism of satiation and proper quantity of food (sauhitya matra)====

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Ghrelin potentially enhances appetite. It is the first hormone which shows stimulating effect on food intake.<ref>Wren AM, Seal LJ, Cohen MA, et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab. 2001;86(12):5992. doi:10.1210/jcem.86.12.8111</ref><ref>Kalra SP, Bagnasco M, Otukonyong EE, Dube MG, Kalra PS. Rhythmic, reciprocal ghrelin and leptin signaling: new insight in the development of obesity. Regul Pept. 2003;111(1-3):1-11. doi:10.1016/s0167-0115(02)00305-1</ref> Ghrelin secreted mainly from the gastric mucosa, its level are at their peak just before a meal, and decreased slowly when food nutrients are travelled into intestine. It acts on hippocampal neurons involved in spatial learning and memory, thus empty stomach passes signal to brain for asking to engage in appetite behavior, filling of hunger. Ghrelin as orexigenic factor promoted food intake and weight gain. Various cognitive components participate in the initiation of eating and in the selection of food. Schmid DA et al research findings suggest that along with stimulation of appetite, Ghrelin affects cognitive functions. They have noted vivid, plastic visualization of preferred meal by study subjects after administration of ghrelin.<ref>Schmid DA, Held K, Ising M, Uhr M, Weikel JC, & Steiger A (2005). Ghrelin Stimulates Appetite, Imagination of Food, GH, ACTH, and Cortisol, but does not Affect Leptin in Normal Controls. Neuropsychopharmacology, 30(6), 1187–1192. https://doi.org/10.1038/sj.npp.1300670</ref> Peptide YY has a suppressive effect on food intake.<ref>Jones ES, Nunn N, Chambers AP, Østergaard S, Wulff BS, Luckman SM. Modified Peptide YY Molecule Attenuates the Activity of NPY/AgRP Neurons and Reduces Food Intake in Male Mice. Endocrinology. 2019 Nov 1;160(11):2737-2747. doi: 10.1210/en.2019-00100. PMID: 31074796; PMCID: PMC6806261.</ref>PPY rise is observed in post prandial phase and are lowest in fasting state. Peripheral administration of PYY3e36 reduces food intake. PPY have shown effect on intestinal motility, delays gastric emptying.<ref>Asakawa A, Inui A, Yuzuriha H, Ueno N, Katsuura G, Fujimiya M, Fujino MA, Niijima A, Meguid MM, Kasuga M. Characterization of the effects of pancreatic polypeptide in the regulation of energy balance. Gastroenterology. 2003 May;124(5):1325-36. doi: 10.1016/s0016-5085(03)00216-6. PMID: 12730873.</ref>  

Ghrelin potentially enhances appetite. It is the first hormone which shows stimulating effect on food intake.<ref>Wren AM, Seal LJ, Cohen MA, et al. Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab. 2001;86(12):5992. doi:10.1210/jcem.86.12.8111</ref><ref>Kalra SP, Bagnasco M, Otukonyong EE, Dube MG, Kalra PS. Rhythmic, reciprocal ghrelin and leptin signaling: new insight in the development of obesity. Regul Pept. 2003;111(1-3):1-11. doi:10.1016/s0167-0115(02)00305-1</ref> Ghrelin secreted mainly from the gastric mucosa, its level are at their peak just before a meal, and decreased slowly when food nutrients are travelled into intestine. It acts on hippocampal neurons involved in spatial learning and memory, thus empty stomach passes signal to brain for asking to engage in appetite behavior, filling of hunger. Ghrelin as orexigenic factor promoted food intake and weight gain. Various cognitive components participate in the initiation of eating and in the selection of food. Schmid DA et al research findings suggest that along with stimulation of appetite, Ghrelin affects cognitive functions. They have noted vivid, plastic visualization of preferred meal by study subjects after administration of ghrelin.<ref>Schmid DA, Held K, Ising M, Uhr M, Weikel JC, & Steiger A (2005). Ghrelin Stimulates Appetite, Imagination of Food, GH, ACTH, and Cortisol, but does not Affect Leptin in Normal Controls. Neuropsychopharmacology, 30(6), 1187–1192. https://doi.org/10.1038/sj.npp.1300670</ref> Peptide YY has a suppressive effect on food intake.<ref>Jones ES, Nunn N, Chambers AP, Østergaard S, Wulff BS, Luckman SM. Modified Peptide YY Molecule Attenuates the Activity of NPY/AgRP Neurons and Reduces Food Intake in Male Mice. Endocrinology. 2019 Nov 1;160(11):2737-2747. doi: 10.1210/en.2019-00100. PMID: 31074796; PMCID: PMC6806261.</ref>PPY rise is observed in post prandial phase and are lowest in fasting state. Peripheral administration of PYY3e36 reduces food intake. PPY have shown effect on intestinal motility, delays gastric emptying.<ref>Asakawa A, Inui A, Yuzuriha H, Ueno N, Katsuura G, Fujimiya M, Fujino MA, Niijima A, Meguid MM, Kasuga M. Characterization of the effects of pancreatic polypeptide in the regulation of energy balance. Gastroenterology. 2003 May;124(5):1325-36. doi: 10.1016/s0016-5085(03)00216-6. PMID: 12730873.</ref>  

===== Signaling pathways involved in the mechanism of satiation =====

=====3. Signaling pathways involved in the mechanism of satiation =====

Food is considered the basic necessity for sustenance of life and attain physical stoutness [Cha.Sa.[[Sutra Sthana]] 25/40(1)]. Energy hemostasis depends on food we consume. Hypothalamus and brainstem are mainly involved to maintain the energy levels. The arcuate nucleus (ARC) of hypothalamus plays important role to control intake of food. ARC has orexigenic neurons (appetite stimulating) and anorexigenic neurons (appetite inhibiting). During digestion, food nutrients stimulate G-protein coupled receptor present on enteroendocrine cell, which stimulates release of gut hormone. Gut hormones influences the vagus nerve, hypothalamus and brainstem. Stimulating and inhibitory neurons present in hypothalamus interact with peripheral signals which results in alteration of eating drive. Vagal afferents stimulated by the gut hormone and sensitive to the stomach's mechanical stretch further connect with the nucleus of the brainstem. Brainstem passes neural signals to hypothalamus. Numerous hormonal and neural signals influence ARC nucleus, which projects to a number of regions including hypothalamic paraventricular nucleus where some essential energy regulating pathways arise.  

Food is considered the basic necessity for sustenance of life and attain physical stoutness [Cha.Sa.[[Sutra Sthana]] 25/40(1)]. Energy hemostasis depends on food we consume. Hypothalamus and brainstem are mainly involved to maintain the energy levels. The arcuate nucleus (ARC) of hypothalamus plays important role to control intake of food. ARC has orexigenic neurons (appetite stimulating) and anorexigenic neurons (appetite inhibiting). During digestion, food nutrients stimulate G-protein coupled receptor present on enteroendocrine cell, which stimulates release of gut hormone. Gut hormones influences the vagus nerve, hypothalamus and brainstem. Stimulating and inhibitory neurons present in hypothalamus interact with peripheral signals which results in alteration of eating drive. Vagal afferents stimulated by the gut hormone and sensitive to the stomach's mechanical stretch further connect with the nucleus of the brainstem. Brainstem passes neural signals to hypothalamus. Numerous hormonal and neural signals influence ARC nucleus, which projects to a number of regions including hypothalamic paraventricular nucleus where some essential energy regulating pathways arise.  

Gastrointestinal track releases various peptide hormones. Stomach has its hormonal and neural control mechanism. Presence of food nutrients along with distention of stomach release gut hormones such as PPY, GLP-1, and oxyntomodulin (OXM).Theses are mainly responsible for phenomenon of satiation. These peptide, decreases hypothalamic orexigenic signaling and increases anorexigenic signaling. Negative feedback mechanism results due to these peptides also contribute to increase satiety between meals. Effect of these gut hormones in union with CNS effect results in satiation and satiety. The enteroendocrine cells released hormones interact at different brain levels through circulation and or through primary afferent neurons. Along with induction of satiation and meal termination, gut hormones also produce a positive feeling of reward and satisfaction. Nutrient sensors and their signaling to brain are vital to give feeling of satisfaction.<ref>Sam AH, Troke RC, Tan TM, Bewick GA. The role of the gut/brain axis in modulating food intake. Neuropharmacology. 2012 Jul;63(1):46-56. doi: 10.1016/j.neuropharm.2011.10.008. Epub 2011 Oct 21. PMID: 22037149</ref> <ref>Murphy KG, Bloom SR. Gut hormones and the regulation of energy homeostasis. Nature. 2006 Dec 14;444(7121):854-9. doi: 10.1038/nature05484. PMID: 17167473.</ref> <ref>Berthoud HR. Vagal and hormonal gut-brain communication: from satiation to satisfaction. Neurogastroenterol Motil. 2008;20 Suppl 1(0 1):64-72. doi:10.1111/j.1365-2982.2008.01104.</ref>

Gastrointestinal tract releases various peptide hormones. Stomach has its hormonal and neural control mechanism. Presence of food nutrients along with distention of stomach release gut hormones such as PPY, GLP-1, and oxyntomodulin (OXM).Theses are mainly responsible for phenomenon of satiation. These peptide, decreases hypothalamic orexigenic signaling and increases anorexigenic signaling. Negative feedback mechanism results due to these peptides also contribute to increase satiety between meals. Effect of these gut hormones in union with CNS effect results in satiation and satiety. The enteroendocrine cells released hormones interact at different brain levels through circulation and or through primary afferent neurons. Along with induction of satiation and meal termination, gut hormones also produce a positive feeling of reward and satisfaction. Nutrient sensors and their signaling to brain are vital to give feeling of satisfaction.<ref>Sam AH, Troke RC, Tan TM, Bewick GA. The role of the gut/brain axis in modulating food intake. Neuropharmacology. 2012 Jul;63(1):46-56. doi: 10.1016/j.neuropharm.2011.10.008. Epub 2011 Oct 21. PMID: 22037149</ref> <ref>Murphy KG, Bloom SR. Gut hormones and the regulation of energy homeostasis. Nature. 2006 Dec 14;444(7121):854-9. doi: 10.1038/nature05484. PMID: 17167473.</ref> <ref>Berthoud HR. Vagal and hormonal gut-brain communication: from satiation to satisfaction. Neurogastroenterol Motil. 2008;20 Suppl 1(0 1):64-72. doi:10.1111/j.1365-2982.2008.01104.</ref>

D Chapelot has described subjective and objective tools for measuring meal size, microstructure of the meal, meal request and inter-meal intervals. A multidimensional approach for assessing satiety is proposed with intensity, duration and intake as main variables.<ref>Chapelot D. Quantifying satiation and satiety. In: Blundell JE, Bellisle F, ed. Satiation, Satiety and the Control of Food Intake:Woodhead Publishing Series in Food Science, Technology and Nutrition; 2013:Pages12-39.  https://www.sciencedirect.com/science/book/9780857095435</ref> Commings DE et.al have reviewed the interaction of gastric, intestinal, and pancreatic signals in food regulation. They have also discussed the important role of short acting GI factors and long-acting adiposity hormones in food intake regulation. Gerry Smith survey indicates that gastric signals are volumetric in nature and intestinal signals are nutritive in nature.<ref>Powley TL, Phillips RJ. Gastric satiation is volumetric, intestinal satiation is nutritive. Physiol Behav. 2004 Aug;82(1):69-74. doi: 10.1016/j.physbeh.2004.04.037. PMID: 15234593.</ref>

D Chapelot has described subjective and objective tools for measuring meal size, microstructure of the meal, meal request and inter-meal intervals. A multidimensional approach for assessing satiety is proposed with intensity, duration and intake as main variables.<ref>Chapelot D. Quantifying satiation and satiety. In: Blundell JE, Bellisle F, ed. Satiation, Satiety and the Control of Food Intake:Woodhead Publishing Series in Food Science, Technology and Nutrition; 2013:Pages12-39.  https://www.sciencedirect.com/science/book/9780857095435</ref> Commings DE et.al have reviewed the interaction of gastric, intestinal, and pancreatic signals in food regulation. They have also discussed the important role of short acting GI factors and long-acting adiposity hormones in food intake regulation. Gerry Smith survey indicates that gastric signals are volumetric in nature and intestinal signals are nutritive in nature.<ref>Powley TL, Phillips RJ. Gastric satiation is volumetric, intestinal satiation is nutritive. Physiol Behav. 2004 Aug;82(1):69-74. doi: 10.1016/j.physbeh.2004.04.037. PMID: 15234593.</ref>

'''Low satiety phenotype:'''  ‘Low satiety phenotype’ is associated with specific behavioral and metabolic profiles that could explain their susceptibility to overeating. These individuals do not recognize their appetite sensation before and after meal. This is considered as an important step in individualized obesity treatment.<ref>DrapeauV, Gallant A. The low satiety phenotype. In: Blundell JE, Bellisle F, ed. Satiation, Satiety and the Control of Food Intake: Woodhead Publishing Series in Food Science, Technology and Nutrition; 2013:Pages 273–297. https://doi.org/10.1533/9780857098719.5.273</ref>

'''Low satiety phenotype:'''  ‘Low satiety phenotype’ is associated with specific behavioral and metabolic profiles that could explain their susceptibility to overeating. These individuals do not recognize their appetite sensation before and after meal. This is considered as an important step in individualized obesity treatment.<ref>DrapeauV, Gallant A. The low satiety phenotype. In: Blundell JE, Bellisle F, ed. Satiation, Satiety and the Control of Food Intake: Woodhead Publishing Series in Food Science, Technology and Nutrition; 2013:Pages 273–297. https://doi.org/10.1533/9780857098719.5.273</ref>

==== Effects of deficient quantity of food ====

==== Effects of deficient or inadequate quantity of food ====

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A deficient and excessive quantity of food both are detrimental to human health. The deficient quantity of food reduces strength, complexion, and nourishment of body tissues and makes the person a home for various disorders of [[vata dosha]]. The quantity of food is one of the major factors which decide the wholesome and unwholesome effect of food on body tissues. [Cha.Sa.[[Sutra Sthana]] 25/32]  

A deficient and excessive quantity of food both are detrimental to human health. The deficient quantity of food reduces strength, complexion, and nourishment of body tissues and makes the person a home for various disorders of [[vata dosha]]. The quantity of food is one of the major factors which decide the wholesome and unwholesome effect of food on body tissues. [Cha.Sa.[[Sutra Sthana]] 25/32]  

# Quantity of each food article in a meal (parigraha).

# Quantity of each food article in a meal (parigraha).

The inclusion of different food articles in a meal is to ascertain all the six rasas (tastes) in the required proportion. The nutritional requirement of everybody tissue is different. Proportionate quantity of six [[rasa]] will ensure the tissue requirement.[Fig.3] The balanced diet concept of [[Ayurveda]] is essentially based of this principle. Imbalanced diet concerning six [[rasa]] leads to improper nourishment of body tissues, which further leads to depletion of body tissues ([[dhatu]]) [Cha. Sa.[[Sutra Sthana]] 5/4-Chakrapani]. Long-term exposure of imbalanced diet triggers wear and tear mechanism of tissues and may result in early senility. Biomedical fundamentals of nutrition, macronutrients and micronutrients need to be studied in correlation with Six Rasa principle to offer better nutritional solutions to the society.

The inclusion of different food articles in a meal is to ascertain all the six rasas (tastes) in the required proportion. The nutritional requirement of everybody tissue is different. Proportionate quantity of six [[rasa]] will ensure the tissue requirement.[Fig.3] The balanced diet concept of [[Ayurveda]] is essentially based of this principle. Imbalanced diet concerning six [[rasa]] leads to improper nourishment of body tissues, which further leads to depletion of body tissues ([[dhatu]]) [Chakrapani on Cha. Sa.[[Sutra Sthana]] 5/4]. Long-term exposure of imbalanced diet triggers wear and tear mechanism of tissues and may result in early senility. Biomedical fundamentals of nutrition, macronutrients and micronutrients need to be studied in correlation with Six Rasa principle to offer better nutritional solutions to the society.

[[File:VM_Pic.PNG|400px|'''Fig.3: Deficiency of food'''|thumb]]

[[File:VM_Pic.PNG|400px|'''Fig.3: Deficiency of food'''|thumb]]

'''Consequences''' : Malnutrition in adults is greatly associated with risk of sarcopenia, frailty, falls, dependence in activities, respiratory muscle wasting, effects musculoskeletal system,  experience metabolic changes in cellular electrolytes including calcium accumulation, reduced resistance to infection, poor functioning of excretory systems, longer hospital stay, poor response to other medical conditions. Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength and it is strictly correlated with physical disability, poor quality of life and death.<ref>Santilli V, Bernetti A, Mangone M, Paoloni M. Clinical definition of sarcopenia. Clin Cases Miner Bone Metab. 2014;11(3):177-180</ref>Cachexia is a multifactorial syndrome with involuntary progressive weight loss as a result of reduction of skeletal muscle mass with or without depletion of adipose tissue.<ref>Vanhoutte G, van de Wiel M, Wouters K, et al. Cachexia in cancer: what is in the definition?. BMJ Open Gastroenterol. 2016;3(1):e000097. Published 2016 Oct 18. doi:10.1136/bmjgast-2016-000097</ref>Frailty is a common clinical syndrome in older adults and is associated with poor health outcomes including falls, disability, hospitalization, decline in functions of various physiological systems and mortality.<ref>Xue QL. The frailty syndrome: definition and natural history. Clin Geriatr Med. 2011;27(1):1-15. doi:10.1016/j.cger.2010.08.009</ref>

'''Consequences''' : Malnutrition in adults is greatly associated with risk of sarcopenia, frailty, falls, dependence in activities, respiratory muscle wasting, effects musculoskeletal system,  experience metabolic changes in cellular electrolytes including calcium accumulation, reduced resistance to infection, poor functioning of excretory systems, longer hospital stay, poor response to other medical conditions. Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength and it is strictly correlated with physical disability, poor quality of life and death.<ref>Santilli V, Bernetti A, Mangone M, Paoloni M. Clinical definition of sarcopenia. Clin Cases Miner Bone Metab. 2014;11(3):177-180</ref>Cachexia is a multifactorial syndrome with involuntary progressive weight loss as a result of reduction of skeletal muscle mass with or without depletion of adipose tissue.<ref>Vanhoutte G, van de Wiel M, Wouters K, et al. Cachexia in cancer: what is in the definition?. BMJ Open Gastroenterol. 2016;3(1):e000097. Published 2016 Oct 18. doi:10.1136/bmjgast-2016-000097</ref>Frailty is a common clinical syndrome in older adults and is associated with poor health outcomes including falls, disability, hospitalization, decline in functions of various physiological systems and mortality.<ref>Xue QL. The frailty syndrome: definition and natural history. Clin Geriatr Med. 2011;27(1):1-15. doi:10.1016/j.cger.2010.08.009</ref>

=====Treatment strategies of undernutrition=====  

===== Treatment strategies of undernutritio n=====  

* Provide dietary solutions considering Guts changes of the elderly.<ref>Rémond D, Shahar DR, Gille D, et al. Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition. Oncotarget. 2015;6(16):13858-13898. doi:10.18632/oncotarget.4030</ref>

* Provide dietary solutions considering Guts changes of the elderly.<ref>Rémond D, Shahar DR, Gille D, et al. Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition. Oncotarget. 2015;6(16):13858-13898. doi:10.18632/oncotarget.4030</ref>

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Excessive food triggers all three [[dosha]] vitiation as there is no space left for [[dosha]] functioning. [[Dosha]] are the main functional unit of human physiology. [[Dosha]] also govern the physiology of digestion. Samana [[vayu]] functions nearby the abode of digestive fire (jatharagni), kindles [[agni]]. Prana [[vayu]] and apana [[vayu]] supports the functions of [[agni]]. Pachaka [[pitta]] when devoid of its liquid property, functions as digestive fire.[A. Hr. Sutra Sthana 12/10-11]<ref name="A. Hridaya"/> Kledaka [[kapha]] is responsible to moisten the ingested food. Thus the process of digestion is driven by [[dosha]]. Factors responsible for complete transformation and absorption of food(ahara parinamakara bhava) explain this phenomenon in-depth. [Cha.Sa.[[Sharira Sthana]]6/14],[Cha.Sa.[[Chikitsa Sthana]] 15/6-8]. The vitiated [[dosha]] leads to the formation of [[ama]].  

Excessive food triggers all three [[dosha]] vitiation as there is no space left for functions of [[dosha]]. [[Dosha]] govern the physiology of digestion. Samana [[vayu]] functions nearby the abode of digestive factors (jatharagni), kindles [[agni]]. Prana [[vayu]] and apana [[vayu]] supports the functions of [[agni]]. Pachaka [[pitta]] when devoid of its liquid property, is responsible for digestion.[A. Hr. Sutra Sthana 12/10-11]<ref name="A. Hridaya"/> Kledaka [[kapha]] is responsible to moisten the ingested food. Thus the process of digestion is driven by [[dosha]]. Factors responsible for complete transformation and absorption of food(ahara parinamakara bhava) explain this phenomenon in-depth. [Cha.Sa.[[Sharira Sthana]]6/14],[Cha.Sa.[[Chikitsa Sthana]] 15/6-8]. The normal functions of digestion and metabolism are not carried out due to the vitiated [[dosha]]. This leads to the formation of [[ama]].  

Excessive eating is one of the etiological factors for non-communicable diseases like obesity and diabetes mellitus which are more prevalent in society. Excess intake of calorie food which is not processed properly by digestive power (jatharagni) and further utilized by dhatvagni (type of [[agni]] present at tissue level) leads to obesity and related disorders.  

Excessive eating is one of the etiological factors for non-communicable diseases like obesity and diabetes mellitus which are more prevalent in society. Excess intake of calorie food which is not processed properly by digestive power (jatharagni) and further utilized by dhatvagni (type of [[agni]] present at tissue level) leads to obesity and related disorders.  

==== Understanding links between mental health and gastrointestinal tract mediated through gut microbiota ====

==== Influnece of mental health on gut microbiota ====

The microbiome is the collective genome of all the microorganisms (bacteria, fungi, protozoa and viruses) living in a particular environment, especially living on and inside the human body. Microbiota is the community of microorganisms. Collective genome of various microorganisms of gastrointestinal (GI) tract, termed as gut microbiome.<ref>Valdes AM, Walter J, Segal E, Spector TD. Role of the gut microbiota in nutrition and health. BMJ. 2018 Jun 13;361:k2179. doi: 10.1136/bmj.k2179. PMID: 29899036; PMCID: PMC6000740.</ref>

The microbiome is the collective genome of all the microorganisms (bacteria, fungi, protozoa and viruses) living in a particular environment, especially living on and inside the human body. Microbiota is the community of microorganisms. Collective genome of various microorganisms of gastrointestinal (GI) tract, termed as gut microbiome.<ref>Valdes AM, Walter J, Segal E, Spector TD. Role of the gut microbiota in nutrition and health. BMJ. 2018 Jun 13;361:k2179. doi: 10.1136/bmj.k2179. PMID: 29899036; PMCID: PMC6000740.</ref>

Gut-Brain axis has bidirectional communication between central and enteric nervous system. It connects emotional and cognitive centers of brain to peripheral intestinal functions. By means of neural, endocrine, immune, and humoral links gut microbiota interact with GBA axis .<ref>Moloney RD, Desbonnet L, Clarke G, Dinan TG, Cryan JF. The microbiome: stress, health and disease. Mamm Genome. 2014 Feb; 25(1-2):49-74. doi: 10.1007/s00335-013-9488-5. Epub 2013 Nov 27.</ref>Marilia Carabotti et al in there review article have explored these interactions, as well as the possible pathophysiological mechanisms involved. Microbiota-gut-brain axis monitors and integrates gut functions and links emotional and cognitive centers of the brain with peripheral intestinal functions. This complex network includes central nervous system (CNS), the autonomic nervous system (ANS), the enteric nervous system (ENS) and the hypothalamic pituitary adrenal (HPA) axis. Central nervous system communicates with enteric nervous system (ENS), intestinal muscle layers and gut mucosa through various afferent and efferent autonomic pathways. Gastrointestinal wall connect with CNS through enteric, spinal and vagal efferent pathways. Limbic system which includes Amygdala (AMG), hippocampus (HIPP), and hypothalamus (HYP): predominantly responsible for memory and emotional responses. Hypothalamic pituitary adrenal (HPA) axis which is a part of limbic system activates in response to emotional stress and releases corticotropin-releasing factor (CRF) from the hypothalamus. CRF further stimulates adrenocorticotropic hormone (ACTH) secretion from the pituitary gland, causing the secretion of cortisol (main Stress hormone) from the adrenal glands. This hormone affects brain functions. Brain through neural communication influences various intestinal cell targets. The Gut microbiota also influences these same cells.  Gut microbiota interact locally with intestinal cells and enteric nervous system (ENS), it also connect with central nervous system (CNS) through neuroendocrine and metabolic pathways.<ref>Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol. 2015 Apr-Jun;28(2):203-209. PMID: 25830558; PMCID:PMC4367209.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367209/#:~:text=The%20gut%2Dbrain%20axis%20(GBA,microbiota%20in%20influencing%20these%20interactions.</ref>

Gut-Brain axis has bidirectional communication between central and enteric nervous system. It connects emotional and cognitive centers of brain to peripheral intestinal functions. By means of neural, endocrine, immune, and humoral links gut microbiota interact with GBA axis .<ref>Moloney RD, Desbonnet L, Clarke G, Dinan TG, Cryan JF. The microbiome: stress, health and disease. Mamm Genome. 2014 Feb; 25(1-2):49-74. doi: 10.1007/s00335-013-9488-5. Epub 2013 Nov 27.</ref>Marilia Carabotti et al in there review article have explored these interactions, as well as the possible pathophysiological mechanisms involved. Microbiota-gut-brain axis monitors and integrates gut functions and links emotional and cognitive centers of the brain with peripheral intestinal functions. This complex network includes central nervous system (CNS), the autonomic nervous system (ANS), the enteric nervous system (ENS) and the hypothalamic pituitary adrenal (HPA) axis. Central nervous system communicates with enteric nervous system (ENS), intestinal muscle layers and gut mucosa through various afferent and efferent autonomic pathways. Gastrointestinal wall connect with CNS through enteric, spinal and vagal efferent pathways. Limbic system which includes Amygdala (AMG), hippocampus (HIPP), and hypothalamus (HYP): predominantly responsible for memory and emotional responses. Hypothalamic pituitary adrenal (HPA) axis which is a part of limbic system activates in response to emotional stress and releases corticotropin-releasing factor (CRF) from the hypothalamus. CRF further stimulates adrenocorticotropic hormone (ACTH) secretion from the pituitary gland, causing the secretion of cortisol (main Stress hormone) from the adrenal glands. This hormone affects brain functions. Brain through neural communication influences various intestinal cell targets. The Gut microbiota also influences these same cells.  Gut microbiota interact locally with intestinal cells and enteric nervous system (ENS), it also connect with central nervous system (CNS) through neuroendocrine and metabolic pathways.<ref>Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol. 2015 Apr-Jun;28(2):203-209. PMID: 25830558; PMCID:PMC4367209.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367209/#:~:text=The%20gut%2Dbrain%20axis%20(GBA,microbiota%20in%20influencing%20these%20interactions.</ref>

Review article of Clair R. Martin et al states that Gut microbes communicate to the central nervous system through at least 3 parallel and interacting channels involving nervous, endocrine, and immune signaling mechanisms. Based on preclinical and clinical evidence from various studies, scholars have concluded that  brain by affecting community structure and functions of gut microbiota can modulate regional gut motility, intestinal transit and secretion, and gut permeability, and potentially through the luminal secretion of hormones that directly modulate microbial gene expression.<ref>Martin CR, Osadchiy V, Kalani A, Mayer EA. The Brain-Gut-Microbiome Axis. Cell Mol Gastroenterol Hepatol. 2018 Apr 12;6(2):133-148. doi: 10.1016/j.jcmgh.2018.04.003. PMID: 30023410; PMCID: PMC6047317.</ref>

Clair R. Martin et al states that Gut microbes communicate to the central nervous system through at least 3 parallel and interacting channels involving nervous, endocrine, and immune signaling mechanisms. Based on preclinical and clinical evidence from various studies, scholars have concluded that  brain by affecting community structure and functions of gut microbiota can modulate regional gut motility, intestinal transit and secretion, and gut permeability, and potentially through the luminal secretion of hormones that directly modulate microbial gene expression.<ref>Martin CR, Osadchiy V, Kalani A, Mayer EA. The Brain-Gut-Microbiome Axis. Cell Mol Gastroenterol Hepatol. 2018 Apr 12;6(2):133-148. doi: 10.1016/j.jcmgh.2018.04.003. PMID: 30023410; PMCID: PMC6047317.</ref>

Research validates the important role of brain and mental health in digestion and metabolism. Mental health is closely linked with gastrointestinal health. Emotions like stress, anxiety, mood swings may trigger stomach problems and gastrointestinal disturbances affect mental health.<ref>Park AJ, Collins J, Blennerhassett PA, Ghia JE, Verdu EF, Bercik P, Collins SM. Altered colonic function and microbiota profile in a mouse model of chronic depression. Neurogastroenterol Motil. 2013 Sep;25(9):733-e575. doi: 10.1111/nmo.12153. Epub 2013 Jun 17. PMID: 23773726; PMCID: PMC3912902.</ref> <ref>Washabau, R. J. (2013). Chapter 41 - Antispasmodic Agents (R. J. Washabau & M. J. B. T.-C. and F. G. Day (eds.); pp. 481–485). W.B. Saunders. https://doi.org/https://doi.org/10.1016/B978-1-4160-3661-6.00041-9

Research validates the important role of brain and mental health in digestion and metabolism. Mental health is closely linked with gastrointestinal health. Emotions like stress, anxiety, mood swings may trigger stomach problems and gastrointestinal disturbances affect mental health.<ref>Park AJ, Collins J, Blennerhassett PA, Ghia JE, Verdu EF, Bercik P, Collins SM. Altered colonic function and microbiota profile in a mouse model of chronic depression. Neurogastroenterol Motil. 2013 Sep;25(9):733-e575. doi: 10.1111/nmo.12153. Epub 2013 Jun 17. PMID: 23773726; PMCID: PMC3912902.</ref> <ref>Washabau, R. J. (2013). Chapter 41 - Antispasmodic Agents (R. J. Washabau & M. J. B. T.-C. and F. G. Day (eds.); pp. 481–485). W.B. Saunders. https://doi.org/https://doi.org/10.1016/B978-1-4160-3661-6.00041-9

==== Causes of [[ama]] formation ====

==== Causes of [[ama]] formation ====

This chapter provides details regarding causative factors of [[ama]] formation. [[Ama]] is unique concept of [[Ayurveda]]. It is the undigested and non-metabolized food material which remains inside the body and produces toxic effects. Quantity of food is considered as an important causative factor in formation of [[ama]]. Excessive as well as deficient quantity of food leads to [[ama]] formation. Along with quantity, if dietetic code and conduct are not followed it may leads to [[ama]] formation. Quality of food like heavy to digest and food with properties like dry, cold, dehydrated, disliked by the consumer, constipation-causing, causing a burning sensation, unclean, incompatible, and/or consumed untimely leads to [[ama]] formation.  

[[Ama]] is unique concept of [[Ayurveda]]. It is the undigested and non-metabolized food material which remains inside the body and produces toxic effects. This chapter provides details regarding causative factors of [[ama]] formation.Improper quantity of food is considered as an important causative factor in formation of [[ama]]. Furthermore, if [[dietary guidelines]] are not followed, it leads to [[ama]] formation.  

 

Quality of food like heavy to digest and food with properties like dry, cold, dehydrated, disliked by the consumer, constipation-causing, causing a burning sensation, unclean, incompatible, and/or consumed untimely leads to [[ama]] formation.  

 

Mental factors like food intake while the mind being afflicted with passion/desires, anger, greed, infatuation, envy, bashfulness, grief, conceit, excitement, and fear are also the cause of formation of [[ama]]. Any unwholesome food, even if taken in right quantity also leads to [[ama]] formation. An individual who regularly consumes an incompatible diet, multiple heavy meals (in short intervals) and eats even before the previous meal is digested, results in a clinical state of indigestion characterized by the manifestation of toxic symptoms termed as "ama visha". Some scholars opine that [[ama]] originate from highly vitiated [[dosha]] itself by their conjugation; as visha (aflatoxins) develops in (stored up, edible) kodo millet (kodrava). [A.Hr. Sutra Sthana 13/26]<ref name="A. Hridaya"/> In recent years many non-communicable and metabolic disorders like obesity, diabetes, and thyroid dysfunction are prevalent in society due to indulgence of above factors leading to [[ama]] formation which triggers enormous pathological conditions. Various causal factors should be avoided by an individual to maintain the status [[agni]] and preserve health.  

Mental factors like food intake while the mind being afflicted with passion/desires, anger, greed, infatuation, envy, bashfulness, grief, conceit, excitement, and fear are also the cause of formation of [[ama]]. Any unwholesome food, even if taken in right quantity also leads to [[ama]] formation. An individual who regularly consumes an incompatible diet, multiple heavy meals (in short intervals) and eats even before the previous meal is digested, results in a clinical state of indigestion characterized by the manifestation of toxic symptoms termed as "ama visha". Some scholars opine that [[ama]] originate from highly vitiated [[dosha]] itself by their conjugation; as visha (aflatoxins) develops in (stored up, edible) kodo millet (kodrava). [A.Hr. Sutra Sthana 13/26]<ref name="A. Hridaya"/> In recent years many non-communicable and metabolic disorders like obesity, diabetes, and thyroid dysfunction are prevalent in society due to indulgence of above factors leading to [[ama]] formation which triggers enormous pathological conditions. Various causal factors should be avoided by an individual to maintain the status [[agni]] and preserve health.  

==== Nature of [[ama]] ====

==== Nature of [[ama]] ====

The [[ama]] is termed as "ama visha" (clinical state of indigestion characterized by manifestation of toxic symptoms) because of resemblance of manifested symptoms to that of poisoning. It is considered incurable because of its acute presentation and contradictory line of management. Physicians describe two types of diseases caused by [[ama]] namely [[visuchika]] (diarrhea and vomiting like symptoms) and [[alasaka]] (sluggish bowels). The [[ama]] which is formed due to weak digestive fire is heavy, liquid, different colored, unctuous, slimy, sticky, undigested, have fetid smell, continuous pain and considered as root cause of many diseases [Arundatta on A.Hr.Sutra Sthana 13/27].<ref name="A. Hridaya"/> This form of food will not be absorbed, gets associated with [[dosha]] leading to "saama dosha" (undigested food with vitiated [[dosha]]) condition.

The [[ama]] is also termed as "ama visha" (clinical state of indigestion characterized by manifestation of toxic symptoms) because of resemblance of manifested symptoms to that of poisoning. It is considered incurable because of its acute presentation and contradictory line of management.

 

Due to various etiological factors, deteriorated state of [[agni]] is unable to digest even the light food. [Cha.Sa.[[Chikitsa Sthana]] 15/43]. This afflicted [[agni]] forms an intermediate substance called [[ama]], which turns sour (shukta) during fermentation and finally turns in poisonous substance. (ama visha) [Cha.Sa.[[Chikitsa Sthana]] 15/44]  

Food if it is properly digested and metabolized by [[agni]] leads to proper tissue formation otherwise leads to poisonous state like [[ama]] formation. Due to various etiological factors deteriorated state of agni is unable to digest even the light food. [Cha.Sa.[[Chikitsa Sthana]] 15/43]. This vitiated digestive fire forms an intermediate substance called [[ama]], which turns sour (shukta) during fermentation and finally turns in poisonous substance. (ama visha) [Cha.Sa.[[Chikitsa Sthana]] 15/44]

The characteristic features of ama include heavyness, liquid, different colored, unctuous, slimy, sticky, undigested, have fetid smell, continuous pain and considered as root cause of many diseases [Arundatta on A.Hr.Sutra Sthana 13/27].<ref name="A. Hridaya"/> This form of food will not be absorbed, gets associated with [[dosha]] leading to "saama dosha" (undigested food with vitiated [[dosha]]) condition.

==== Symptoms produced due to [[ama]] ====

==== Symptoms produced due to [[ama]] ====

Following  are symptoms produced by ama in various body systems and comprise symptoms of [[dosha]] associated with [[ama]]. [A.H. Sutra Sthana 13/23-24]<ref name="A. Hridaya"/>  

Following  are symptoms produced by [[ama]] in various body systems and comprise symptoms of [[dosha]] associated with [[ama]]. [A.H. Sutra Sthana 13/23-24]<ref name="A. Hridaya"/>  

*Obstruction of body channels (srotorodha)  

*Obstruction of body channels (srotorodha)  

==== Disorders of [[ama]] ====

==== Disorders of [[ama]] ====

Two types of diseases caused by [[ama]] namely [[visuchika]] (diarrhea and vomiting) and [[alasaka]] (sluggish bowels). A frail person having weak digestive power and aggravated [[kapha]] condition, even exerting pressure does not push the undigested food out of the passage since it is obstructed by [[kapha]]. This condition is called [[alasaka]]. Taking food either in excess quantity or very little quantity is a type of "vishamashana" (a type of unhealthy dietary pattern). This leads to various [[ama]] disorders [Cha.Sa.[[Chikitsa Sthana]] 15/236].

Two types of disordres are caused by [[ama]] viz. [[visuchika]] (non infectious gastroenteritis) and [[alasaka]] (sluggish bowels). [[Visuchika]] is characterized by suddent vomiting, diarhoea and pricking pain in abdomen. A frail person having weak digestive power and aggravated [[kapha]] condition, even exerting pressure is not able to elimiate the undigested food out of the passage. This condition is called [[alasaka]].  

==== Assessment of [[ama]] ====

==== Assessment of [[ama]] ====

==== Management principles of [[ama]] ====

==== Management principles of [[ama]] ====

[[Ama]] is the preliminary cause for many disorders; hence the term ‘aamaya’ (means indigestion) is enlisted as the synonym of disease. [Chakrapani on Cha.Sa.[[Nidana Sthana]] 1/15] Physician should assess the status of [[agni]] and severity of [[ama]] before starting any treatment or therapeutic procedure. Treatment in 'saama' (presence of ama in pathogenesis of disease) and 'niraama' (absence of ama in pathogenesis) conditions are totally different.  

[[Ama]] is the preliminary cause for many disorders; hence the term ‘aamaya’ (means indigestion) is enlisted as the synonym of disease. [Chakrapani on Cha.Sa.[[Nidana Sthana]] 1/15] Physician should assess the status of [[agni]] and severity of [[ama]] before starting any treatment or therapeutic procedure. Treatment in 'saama' (presence of ama in pathogenesis of disease) and 'niraama' (absence of [[ama]] in pathogenesis) conditions are totally different.  

===== Contraindication of [[shodhana]] in [[ama]] associated state =====

===== Contraindication of [[shodhana]] in [[ama]] associated state =====

===== Primary treatment measures =====

===== Primary treatment measures =====

[[Langhana]] (measures of fasting and lightness by removing wastes) and [[pachana]] (digestive therapy) is the foremost treatment used to treat [[ama]] disorders. [Cha.Sa.[[Chikitsa Sthana]] 15/95] Fasting helps to digest [[ama]] and kindles digestive fire. Absolute fasting or liquid light food is advised considering state of [[ama]]. [[Agni]] is responsible for digestion of food; kindled digestive fire in absence of food will digest increased [[dosha]] or remainant of [[ama]] in the body. [A. Hr. Chikitsa Sthana 10/91]<ref name="A. Hridaya"/>

[[Langhana]] (measures of fasting and lightness by removing wastes) and [[pachana]] (digestive therapy) is the foremost treatment used to treat [[ama]] disorders. [Cha.Sa.[[Chikitsa Sthana]] 15/95] Fasting helps to digest [[ama]] and kindles digestive fire. Absolute fasting or liquid light food is advised considering state of [[ama]]. [[Agni]] is responsible for digestion of food; kindled digestion in absence of food will digest increased [[dosha]] or remnant of [[ama]] in the body. [A. Hr. Chikitsa Sthana 10/91]<ref name="A. Hridaya"/>

When the digestion of food is completed, but yet the patient experiences fullness and heaviness of the stomach, medicines are to be given which bring about the breakdown of the remaining [[dosha]] and increase digestive process. After [[langhana]] and [[pachana]] therapies, patient should be advised to follow special dictum of dietary regimen starting from thin gruel (peyadi sansarjana krama) to ignite digestive process. Fasting reduces the aggravated [[dosha]], kindles digestive power, restores appetite, and renders lightness to the body. Fasting should be performed to that extent which will not hamper the vitality or strength of an individual. The aim of all these measures is to regain the health which also depends on the physical, mental and spiritual well being. [Cha.Sa.[[Chikitsa Sthana]] 3/140-142]

When the digestion of food is completed, but yet the patient experiences fullness and heaviness of the stomach, medicines are to be given which bring about the breakdown of the remaining [[dosha]] and increase digestive process. After [[langhana]] and [[pachana]] therapies, patient should be advised to follow special dictum of dietary regimen starting from thin gruel (peyadi sansarjana krama) to ignite digestive process. Fasting reduces the aggravated [[dosha]], kindles digestive power, restores appetite, and renders lightness to the body. Fasting should be performed to that extent which will not hamper the vitality or strength of an individual. The aim of all these measures is to regain the health which also depends on the physical, mental and spiritual well being. [Cha.Sa.[[Chikitsa Sthana]] 3/140-142]

==== Cauterization ([[Agni karma]]) ====

==== Cauterization ([[Agni karma]]) ====

   

   

In severe cases of [[visuchika]] (indigestion with vomiting and diarrhea), cauterization on the heels is recommended. [A.S. Sutra Sthana 11/26]

In severe cases of [[visuchika]] (non infectious gastroenteritis), cauterization on the heels is recommended. [A.S. Sutra Sthana 11/26]

==== Clinical assessment of complete digestion ====

==== Clinical assessment of complete digestion ====

==== Prevention of [[ama]] formation ====

==== Prevention of [[ama]] formation ====

The dietary guidelines ([[ahara vidhi]]) shall be strictly followed to prevent formation of [[ama]]. Taking food twice only in day is important measure to prevent formation of [[ama]]. [[Ayurveda]] prohibits the ingestion of food during night time. Hence, during day two meal times are suggested for health preservation. The ideal times are when the person feels hungry in the morning and evening before sunset. [Indu on A.S.Sutra Sthana 11/54] Bhavamishra advises to take food after three hours of sunrise for proper digestion suggest avoiding food past afternoon. The second meal can be taken before sunset. [B.P.Pradhama Khanda 4/115-116] It is advisable to consume that quantity of food which will be digested within twelve hours, without disturbing daily physical activities. Many efforts have been taken in biomedical science to unlock the complex mechanism underling this appetite science.

The dietary guidelines ([[ahara vidhi]]) shall be strictly followed to prevent formation of [[ama]]. Taking food twice only in day is important measure to prevent formation of [[ama]]. [[Ayurveda]] prohibits the ingestion of food during night time. Hence, during day two meal times are suggested for health preservation. The ideal times are when the person feels hungry in the morning and evening before sunset. [Indu on A.S.Sutra Sthana 11/54] Bhavamishra advises to take food after three hours of sunrise for proper digestion suggest avoiding food past afternoon. The second meal can be taken before sunset. [B.P.Prathama Khanda 4/115-116] It is advisable to consume that quantity of food which will be digested within twelve hours, without disturbing daily physical activities. Many efforts have been taken in biomedical science to unlock the complex mechanism underling this appetite science.

 

 

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==== Contemporary views and research updates on [[ama]] ====  

==== Contemporary views and research updates on [[ama]] ====  

[[Ama]] is an important principle to understand the etiopathogenetic of all disorders and to decide the treatment modalities. [[Agni]] is the digestive and metabolic factor responsible for any transformation in body. Transformation of food material predominantly takes place at the level of gastrointestinal tract ([[grahani]]-seat of jatharagni) and at the level of tissues (dhatvagni-abodes of [[dhatu]]). Dysfunction of [[agni]] results into undigested or partly digested intermediator product called as [[ama]]. [[Ama]] act as toxic element and form the basis for many pathological conditions. It can be considered raw, uncooked, unripe, immature, undigested or incompletely oxidized / metabolized or similar to a poisonous substance that disrupts body physiology. Accumulation of metabolic waste ([[mala]]) may takes place at various levels in body physiology. The amalgamation of aggravated [[dosha]] with metabolic waste results in [[ama]] formation, which is considered the initial stage of disease formation. Origin of [[ama]] is mainly considered from gastrointestinal tract ([[amashaya]]). [[Agni]] functions at different levels; hence, [[ama]] can be formed at different levels at different body sites. Forms of [[agni]] - jatharagni, bhutagni and dhatvagni functions at different level hence any impairment at the corresponding level leads to [[ama]] formation.

==== [[Ama]] formation in mouth ====

 

Digestion of food starts in mouth. If person is not following [[dietary guidelines]] codes, eating hurriedly without proper mastication, disturbed mental health while taking food will affect the first cephalic phase of digestion. It will lead to [[ama]] formation due to improper digestion process in mouth. Mastication of food is subjected to condition of teeth.  Studies have attempted to find a correlation between tooth loss and nutrition. Deteriorated dental health affects mechanical digestion process and leads to nutritional deficiency.<ref>Najeeb S, Zafar MS, Khurshid Z, Zohaib S, Almas K. The role of nutrition in periodontal health: An Update. Nutrients. 2016 Aug 30;8(9):530. doi: 10.3390/nu8090530. PMID: 27589794; PMCID: PMC5037517. </ref> Another study observed that modifying the mastication rate alters the glycemic index of rice. Its glycemic index classification shows impact of digestion process on the final outcome of food.<ref>Ranawana, V., Leow, M. K.-S., & Henry, C. J. K. (2014). Mastication effects on the glycemic index: impact on variability and practical implications. European Journal of Clinical Nutrition, 68(1), 137–139. https://doi.org/10.1038/ejcn.2013.231</ref>

Digestion process starts from mouth where mechanical and chemical digestion of food takes place. Thinking, smelling and seeing food secrets saliva, helps in digestion. Component of saliva like water, mucus, electrolytes and enzymes has a unique function. Starch breakdown starts here due to the enzyme in saliva called salivary amylase. Mucus lubricates the food and helps in the formation of bolus in mouth. Small food particles are dissolved by saliva and it makes dry food moist enough to swallow comfortably. If person is not following dietary codes, eating hurriedly without proper mastication, disturbed mental health while taking food will affect this cephalic phase of digestion. It will lead to [[ama]] formation due to improper digestion process in mouth. Mastication of food is subjected to condition of teeth.  Studies have attempted to find a correlation between tooth loss and nutrition. Deteriorated dental health affects mechanical digestion process and leads to nutritional deficiency.<ref>Najeeb S, Zafar MS, Khurshid Z, Zohaib S, Almas K. The role of nutrition in periodontal health: An Update. Nutrients. 2016 Aug 30;8(9):530. doi: 10.3390/nu8090530. PMID: 27589794; PMCID: PMC5037517. </ref> Another study observed that modifying the mastication rate alters the glycemic index of rice. Its glycemic index classification shows impact of digestion process on the final outcome of food.<ref>Ranawana, V., Leow, M. K.-S., & Henry, C. J. K. (2014). Mastication effects on the glycemic index: impact on variability and practical implications. European Journal of Clinical Nutrition, 68(1), 137–139. https://doi.org/10.1038/ejcn.2013.231</ref>

==== [[Ama]] formation in gut ====

Health of a person is essentially dependents on healthy gut. Mucosal integrity is more important for proper absorption of nutrient from villi. The intestines also play an essential role in protecting the body from harmful bacteria and toxins. If mucosal integrity is hampered it results into leaky gut syndrome. It affects the lining of intestinal mucosa leading to bacteria and other toxins to pass into the bloodstream. It also leads to the imbalance of gut microbiome.<ref>Gerwyn Morris, Michael Berk, André F. Carvalho, Javier R. Caso, Yolanda Sanz and Michael Maes, “The Role of Microbiota and Intestinal Permeability in the Pathophysiology of Autoimmune and Neuroimmune Processes with an Emphasis on Inflammatory Bowel Disease Type 1 Diabetes and Chronic Fatigue Syndrome”, Current Pharmaceutical Design (2016) 22: 6058. https://doi.org/10.2174/1381612822666160914182822</ref>  

Health of a person is essentially dependents on healthy gut. Mucosal integrity is more important for proper absorption of nutrient from villi. The intestines also play an essential role in protecting the body from harmful bacteria and toxins. If mucosal integrity is hampered it results into leaky gut syndrome. It affects the lining of intestinal mucosa leading to bacteria and other toxins to pass into the bloodstream. It also leads to the imbalance of gut microbiome.<ref>Gerwyn Morris, Michael Berk, André F. Carvalho, Javier R. Caso, Yolanda Sanz and Michael Maes, “The Role of Microbiota and Intestinal Permeability in the Pathophysiology of Autoimmune and Neuroimmune Processes with an Emphasis on Inflammatory Bowel Disease Type 1 Diabetes and Chronic Fatigue Syndrome”, Current Pharmaceutical Design (2016) 22: 6058. https://doi.org/10.2174/1381612822666160914182822</ref>  

This gut leakage and dysbiosis leads to gut inflammation, also disrupt an immune homeostasis. It causes systemic immune activation, neurological disturbances and auto immune diseases. All these predisposing conditions cause [[ama]] formation which triggers many complex pathological conditions, act as route cause for many diseases.<ref>Sharma H. Leaky Gut Syndrome, Dysbiosis, Ama, Free Radicals, and Natural Antioxidants. AYU. 2009; 30 (2): 88-105.</ref>

This gut leakage and dysbiosis leads to gut inflammation, also disrupt an immune homeostasis. It causes systemic immune activation, neurological disturbances and auto immune diseases. All these predisposing conditions cause [[ama]] formation which triggers many complex pathological conditions, act as route cause for many diseases.<ref>Sharma H. Leaky Gut Syndrome, Dysbiosis, Ama, Free Radicals, and Natural Antioxidants. AYU. 2009; 30 (2): 88-105.</ref>

Formation of [[ama]] occurs at the level of tissues or cellular level due to impaired metabolism or due to free radical activity. Free radicals are highly reactive atom or molecule which is having one or more unpaired electrons. It always tries to have stability by giving its electron or by acquiring extra electron form adjacent molecules. After providing the electron adjacent molecule becomes unstable and acts as a free radical, a chain reaction sets in to damage many molecules. A higher concentration of free radicals causes damage to the cellular structure like DNA, protein, lipid, and other cell parts. It causes disturbance in homeostasis of body leading to disease condition.<ref>Sharma GN, Gupta G, Sharma P. A Comprehensive Review of Free Radicals, Antioxidants, and Their Relationship with Human Ailments. Crit Rev Eukaryot Gene Expr. 2018;28(2):139-154. doi:10.1615/CritRevEukaryotGeneExpr.2018022258</ref>

Formation of [[ama]] occurs at the level of tissues or cellular level due to impaired metabolism or due to free radical activity. Free radicals are highly reactive atom or molecule which is having one or more unpaired electrons. It always tries to have stability by giving its electron or by acquiring extra electron form adjacent molecules. After providing the electron adjacent molecule becomes unstable and acts as a free radical, a chain reaction sets in to damage many molecules. A higher concentration of free radicals causes damage to the cellular structure like DNA, protein, lipid, and other cell parts. It causes disturbance in homeostasis of body leading to disease condition.<ref>Sharma GN, Gupta G, Sharma P. A Comprehensive Review of Free Radicals, Antioxidants, and Their Relationship with Human Ailments. Crit Rev Eukaryot Gene Expr. 2018;28(2):139-154. doi:10.1615/CritRevEukaryotGeneExpr.2018022258</ref>

[[Ama]] formation occurs due to the accumulation of toxic or intermediate product of metabolism in the body termed as mala. These intermediate products are formed due to defect in the metabolism of protein, carbohydrate or lipid. Excessive uric acid is formed due to improper metabolism of protein which is hazardous to body tissue and joint structure. Lactic acid, acetone and ketone bodies are formed due to improper metabolism of carbohydrate and fats. Lack of insulin activity defunct carbohydrate metabolism and leads to formation of intermediate products in the body. This intermediate products act as [[ama]] and leads to many disease conditions.

 

[[Ama]] formation occurs due to the accumulation of toxic or intermediate product of metabolism in the body termed as [[mala]]. These intermediate products are formed due to defect in the metabolism of protein, carbohydrate or lipid. Excessive uric acid is formed due to improper metabolism of protein which is hazardous to body tissue and joint structure. Lactic acid, acetone and ketone bodies are formed due to improper metabolism of carbohydrate and fats. Lack of insulin activity defunct carbohydrate metabolism and leads to formation of intermediate products in the body. This intermediate products act as [[ama]] and leads to many disease conditions.

'''Metabolic waste functions as [[ama]]''': Tissue nutrients after action of metabolism (dhatvagni) nourishes body tissues and part is formed as excretory product ([[mala]]). Accumulation of this metabolic waste beyond certain limits disrupts the [[dosha]] hemostasis, leads to formation of [[ama]]. Depending on the type of metabolic waste and predominance of [[dosha]] exhibits many diseases.  

'''Metabolic waste functions as [[ama]]''': Tissue nutrients after action of metabolism (dhatvagni) nourishes body tissues and part is formed as excretory product ([[mala]]). Accumulation of this metabolic waste beyond certain limits disrupts the [[dosha]] hemostasis, leads to formation of [[ama]]. Depending on the type of metabolic waste and predominance of [[dosha]] exhibits many diseases.  

*[[Grahani Chikitsa]]

*[[Grahani Chikitsa]]

*[[Ahara vidhi]]

*[[Ahara vidhi]]

==References ==

==References ==