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*Striking seasonal variations have been demonstrated in the plasma and saliva levels of the glucocorticoid, cortisol, which promotes carbohydrate metabolism. The lowest levels of cortisol were found in healthy individuals during spring and summer, while the highest levels were found during autumn and winter seasons.<ref>  Walker et al, 1997 </ref>
 
*Striking seasonal variations have been demonstrated in the plasma and saliva levels of the glucocorticoid, cortisol, which promotes carbohydrate metabolism. The lowest levels of cortisol were found in healthy individuals during spring and summer, while the highest levels were found during autumn and winter seasons.<ref>  Walker et al, 1997 </ref>
 
*''Agni'' (digestive power) of individuals is strong during winter i.e. ''hemanta'' and ''shishira ritu'', and weakest during ''grishma'' and ''varsha ritu.''
 
*''Agni'' (digestive power) of individuals is strong during winter i.e. ''hemanta'' and ''shishira ritu'', and weakest during ''grishma'' and ''varsha ritu.''
 
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*Rheumatic diseases vary in severity by season. The incidence of acute gouty attacks (an inflammatory arthritis) is highest in the spring season.<ref> Schlesinger N et al., 1998 </ref> Schlesinger N.et al. (2009) explained in his paper “Seasonal Variation of Rheumatic Diseases” that seasonal variation has been shown in a number of rheumatic diseases.<ref> Schlesinger N et al, 2009 </ref>
Rheumatic diseases vary in severity by season. The incidence of acute gouty attacks (an inflammatory arthritis) is highest in the spring season.<ref> Schlesinger N et al., 1998 </ref> Schlesinger N.et al. (2009) explained in his paper “Seasonal Variation of Rheumatic Diseases” that seasonal variation has been shown in a number of rheumatic diseases.<ref> Schlesinger N et al, 2009 </ref>
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*Coronary artery disease shows a winter peak and summer trough in incidence and mortality.<ref> Sher L., 2001 </ref> Leo Sher also proposed that seasonal mood changes may contribute to the increased incidence and mortality of coronary artery disease in winter. Depression is associated with increased incidence, morbidity, and mortality of coronary artery disease.
 
*Coronary artery disease shows a winter peak and summer trough in incidence and mortality.<ref> Sher L., 2001 </ref> Leo Sher also proposed that seasonal mood changes may contribute to the increased incidence and mortality of coronary artery disease in winter. Depression is associated with increased incidence, morbidity, and mortality of coronary artery disease.
 
“Seasonal affective disorder” is a condition where depression in the winter and fall alternate with non-depressive periods in the spring and summer. The degree to which seasonal changes affect mood, energy, sleep, appetite, food preference, or the wish to socialize with other people has been called "seasonality." Recent studies have demonstrated that seasonal mood changes are related to the genetic factors. It means that people may have genetically‐determined sensitivity to seasons.     
 
“Seasonal affective disorder” is a condition where depression in the winter and fall alternate with non-depressive periods in the spring and summer. The degree to which seasonal changes affect mood, energy, sleep, appetite, food preference, or the wish to socialize with other people has been called "seasonality." Recent studies have demonstrated that seasonal mood changes are related to the genetic factors. It means that people may have genetically‐determined sensitivity to seasons.     

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