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The most common inherited bleeding disorders are:
 
The most common inherited bleeding disorders are:
*hemophilia A and B: caused by a deficiency or lack of certain blood clotting proteins, called factors. This disorder causes heavy or unusual bleeding
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*'''Hemophilia A and B''': caused by a deficiency or lack of certain blood clotting proteins, called factors. This disorder causes heavy or unusual bleeding
*factor II, V, VII, X, XII deficiency: relate to blood clotting problems or abnormal bleeding problems
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*'''Factor II, V, VII, X, XII deficiency''': relate to blood clotting problems or abnormal bleeding problems
*von Willebrand’s disease: the most common inherited bleeding disorder; caused by a deficiency of von Willebrand factor, which helps blood platelets clump together and stick to a blood vessel wall  
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*'''von Willebrand’s Disease''': the most common inherited bleeding disorder; caused by a deficiency of von Willebrand factor, which helps blood platelets clump together and stick to a blood vessel wall.
    
Certain diseases or medical conditions can also cause a deficiency of one or more blood clotting factors. The most common causes of acquired bleeding disorders are end-stage liver disease or vitamin K deficiency. According to the American Association of Clinical Chemistry (AACC), this is because most blood clotting factors are produced in the liver, and certain clotting factors are vitamin k dependent (AACC, 2011).
 
Certain diseases or medical conditions can also cause a deficiency of one or more blood clotting factors. The most common causes of acquired bleeding disorders are end-stage liver disease or vitamin K deficiency. According to the American Association of Clinical Chemistry (AACC), this is because most blood clotting factors are produced in the liver, and certain clotting factors are vitamin k dependent (AACC, 2011).