Changes

As mentioned earlier, ''prameha'' can be correlated with obesity, metabolic syndrome, and diabetes mellitus. The early manifestation of the disease process in these conditions is characterized by lipid, carbohydrate, and protein metabolism disturbances accompanied by glycosuria, proteinuria, etc., which can be equates with a ''kaphaja'' condition (i.e., which can be easily controlled and cured.  ''Pittaja prameha'' can be correlated with the inflammatory conditions accompanied with diabetes like urinary tract infection and diabetic ketoacidosis. The advanced stage of disease, with metabolic disturbances associated with loss of immunity, correlates with type 2 diabetes that has progressed to insulin dependent diabetes, and correlates with the hereditary form of type 1 diabetes, which both correlate with ''vataja prameha''. Both of these forms are incurable as described by Charaka.

As mentioned earlier, ''prameha'' can be correlated with obesity, metabolic syndrome, and diabetes mellitus. The early manifestation of the disease process in these conditions is characterized by lipid, carbohydrate, and protein metabolism disturbances accompanied by glycosuria, proteinuria, etc., which can be equates with a ''kaphaja'' condition (i.e., which can be easily controlled and cured.  ''Pittaja prameha'' can be correlated with the inflammatory conditions accompanied with diabetes like urinary tract infection and diabetic ketoacidosis. The advanced stage of disease, with metabolic disturbances associated with loss of immunity, correlates with type 2 diabetes that has progressed to insulin dependent diabetes, and correlates with the hereditary form of type 1 diabetes, which both correlate with ''vataja prameha''. Both of these forms are incurable as described by Charaka.

==== Prameha classified according to physique ====

==== ''Prameha'' classified according to physique ====

Charaka Samhita has classified the patients of prameha into two main categories on the basis of their body constitution with regard to physique::

[[Charaka Samhita]] has classified the patients of ''prameha'' into two main categories on the basis of their body constitution with regard to physique::

1. Sthula pramehi refers to obese diabetic patients and corresponds to individuals with Type 2 diabetes, and  

#''Sthula pramehi'' refers to obese diabetic patients and corresponds to individuals with Type 2 diabetes, and  

2. Krisha pramehi refers to asthenic diabetic patients and corresponds to krisha pramehi corresponds to patients with Type-I diabetes.   

#''Krisha pramehi'' refers to asthenic diabetic patients and corresponds to ''krisha pramehi'' corresponds to patients with Type-I diabetes.   

Research shows that sedentary lifestyle, coupled with an excessive intake of sugar-rich substances lead to a build up of toxins that could be equated to ama (or toxins resulting from improperly digested food and metabolic products). This ama then leads to the formation of meda (fat).  When this resultant meda is also coupled with vitiated doshas (primarily, kapha and vata), and agni (the digestive processes), it provides for a conducive ground for the causation of prameha.

Research shows that sedentary lifestyle, coupled with an excessive intake of sugar-rich substances lead to a build up of toxins that could be equated to ama (or toxins resulting from improperly digested food and metabolic products). This ama then leads to the formation of meda (fat).  When this resultant meda is also coupled with vitiated doshas (primarily, kapha and vata), and agni (the digestive processes), it provides for a conducive ground for the causation of prameha.

Modern scientific research also correlates insulin resistance with obesity, where insulin resistance increases with weight gain and reduces with weight loss. Hormones such as resistin (derived from adipose tissues) provide for a direct link between obesity and diabetes, as they cause insulin resistance.  

Modern scientific research also correlates insulin resistance with obesity, where insulin resistance increases with weight gain and reduces with weight loss. Hormones such as resistin (derived from adipose tissues) provide for a direct link between obesity and diabetes, as they cause insulin resistance.  

  In Ayurveda, much emphasis has been given to the role of meda in the pathogenesis of prameha. However, its role is not only as a dushya (disturbed functioning of the dhatus), but something more than that. Bahudrava shleshma (kapha that contains too much liquid) joins and affects meda, causing it to become abadha (unobstructed or fluid) in nature. This form of meda has been described to have an effect on mamsa (muscle tissue), thereby increasing the volume of body fluid. This has been described as sharira- kleda (body fluid). This route of pathogenesis for prameha is closely related to obesity.  

  In Ayurveda, much emphasis has been given to the role of meda in the pathogenesis of prameha. However, its role is not only as a dushya (disturbed functioning of the dhatus), but something more than that. Bahudrava shleshma (kapha that contains too much liquid) joins and affects meda, causing it to become abadha (unobstructed or fluid) in nature. This form of meda has been described to have an effect on mamsa (muscle tissue), thereby increasing the volume of body fluid. This has been described as sharira- kleda (body fluid). This route of pathogenesis for prameha is closely related to obesity.

==== Samprapti (pathogenesis) of prameha ====

==== Samprapti (pathogenesis) of prameha ====