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''Dravyas'' with properties of ''ushna'' (hot), ''tikshna'' (sharp), ''sukshma'' (minute), ''laghu'' (light), ''ruksha'' (rough), ''vishada'' (non-slimy) and predominant ''rupa'' is ''agneya'' (i.e., constituting primarily of ''agni'' (''tejas bhuta'')) produce ''daha'' (burning/heat), ''paka'' (digestion), ''prabha'' (luster), ''prakash'' (light) and ''varna'' (complexion).
 
''Dravyas'' with properties of ''ushna'' (hot), ''tikshna'' (sharp), ''sukshma'' (minute), ''laghu'' (light), ''ruksha'' (rough), ''vishada'' (non-slimy) and predominant ''rupa'' is ''agneya'' (i.e., constituting primarily of ''agni'' (''tejas bhuta'')) produce ''daha'' (burning/heat), ''paka'' (digestion), ''prabha'' (luster), ''prakash'' (light) and ''varna'' (complexion).
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''Dravyas'' having properties of ''laghu'' (light), ''sheeta'' (cold), ''ruksha'' (rough), ''khara'' (coarse), ''vishada'' (non-slimy), ''sukshma'' (minute) and the predominant ''sparsha'' is ''vayavya'' (i.e., primarily made up of vayu bhuta). They produce actions of raukshya (roughness), glani (depression), vichara (movement), vaishdya (non-sliminess) and laghava (lightness).
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''Dravyas'' having properties of ''laghu'' (light), ''sheeta'' (cold), ''ruksha'' (rough), ''khara'' (coarse), ''vishada'' (non-slimy), ''sukshma'' (minute) and the predominant ''sparsha'' is ''vayavya'' (i.e., primarily made up of ''vayu bhuta''). They produce actions of ''raukshya'' (roughness), ''glani'' (depression), ''vichara'' (movement), ''vaishdya'' (non-sliminess) and ''laghava'' (lightness).
Dravyas having predominance in the properties of mrudu (soft), laghu (light), sukshma (minute), shlakshna (smooth)and the predominantly shabda are akashiya (constituted predominantly of akasha bhuta). They exert actions of softening, hollowing and making light. [11]
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''Dravyas'' having predominance in the properties of ''mridu'' (soft), ''laghu'' (light), ''sukshma'' (minute), ''shlakshna'' (smooth)and the predominantly ''shabda'' are ''akashiya'' (constituted predominantly of ''akasha bhuta''). They exert actions of softening, hollowing and making light. [11]
    
अनेनोपदेशेन नानौषधिभूतं जगति किञ्चिद्द्रव्यमुपलभ्यते  
 
अनेनोपदेशेन नानौषधिभूतं जगति किञ्चिद्द्रव्यमुपलभ्यते  
 
तां तां युक्तिमर्थं च तं तमभिप्रेत्य||१२||
 
तां तां युक्तिमर्थं च तं तमभिप्रेत्य||१२||
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anēnōpadēśēna nānauṣadhibhūtaṁ jagati kiñciddravyamupalabhyatē  
 
anēnōpadēśēna nānauṣadhibhūtaṁ jagati kiñciddravyamupalabhyatē  
 
tāṁ tāṁ yuktimarthaṁ ca taṁ tamabhiprētya||12||  
 
tāṁ tāṁ yuktimarthaṁ ca taṁ tamabhiprētya||12||  
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anenopadeshena nAnauShadhibhUtaM jagati ki~jciddravyamupalabhyate tAM tAM yuktimarthaM ca taM tamabhipretya||12||
 
anenopadeshena nAnauShadhibhUtaM jagati ki~jciddravyamupalabhyate tAM tAM yuktimarthaM ca taM tamabhipretya||12||
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On this basis, there is no substance in the universe which cannot be used as a medicinal drug, on the condition that they are used with rational method and with a definite objective. [12]   
 
On this basis, there is no substance in the universe which cannot be used as a medicinal drug, on the condition that they are used with rational method and with a definite objective. [12]   
Description of drug action:
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==== Description of drug action ====
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न तु केवलं गुणप्रभावादेव द्रव्याणि कार्मुकाणि भवन्ति; द्रव्याणि हि  
 
न तु केवलं गुणप्रभावादेव द्रव्याणि कार्मुकाणि भवन्ति; द्रव्याणि हि  
 
द्रव्यप्रभावाद्गुणप्रभावाद्द्रव्यगुणप्रभावाच्च तस्मिंस्तस्मिन्  
 
द्रव्यप्रभावाद्गुणप्रभावाद्द्रव्यगुणप्रभावाच्च तस्मिंस्तस्मिन्  
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यदा कुर्वन्ति, स कालः; यथा कुर्वन्ति, स उपायः; यत् साधयन्ति, तत्  
 
यदा कुर्वन्ति, स कालः; यथा कुर्वन्ति, स उपायः; यत् साधयन्ति, तत्  
 
फलम्||१३||
 
फलम्||१३||
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na tu kēvalaṁ guṇaprabhāvādēva dravyāṇi kārmukāṇi bhavanti;  
 
na tu kēvalaṁ guṇaprabhāvādēva dravyāṇi kārmukāṇi bhavanti;  
 
dravyāṇi hi dravyaprabhāvādguṇaprabhāvāddravyaguṇaprabhāvācca  
 
dravyāṇi hi dravyaprabhāvādguṇaprabhāvāddravyaguṇaprabhāvācca  
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yatra kurvanti, tadadhikaraṇaṁ; yadā kurvanti, sa kālaḥ; yathā kurvanti,  
 
yatra kurvanti, tadadhikaraṇaṁ; yadā kurvanti, sa kālaḥ; yathā kurvanti,  
 
sa upāyaḥ; yat sādhayanti, tat phalam||13||  
 
sa upāyaḥ; yat sādhayanti, tat phalam||13||  
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na tu kevalaM guNaprabhAvAdeva dravyANi kArmukANi bhavanti; dravyANi hi dravyaprabhAvAdguNaprabhAvAddravyaguNaprabhAvAcca tasmiMstasmin kAletattadadhikaraNamAsAdya tAM tAM ca yuktimarthaM ca taM tamabhipretya yat kurvanti, tat karma; yena kurvinti, tadvIryaM; yatra kurvanti, tadadhikaraNaM; yadAkurvanti, sa kAlaH; yathA kurvanti, sa upAyaH; yat sAdhayanti, tat phalam||13||  
 
na tu kevalaM guNaprabhAvAdeva dravyANi kArmukANi bhavanti; dravyANi hi dravyaprabhAvAdguNaprabhAvAddravyaguNaprabhAvAcca tasmiMstasmin kAletattadadhikaraNamAsAdya tAM tAM ca yuktimarthaM ca taM tamabhipretya yat kurvanti, tat karma; yena kurvinti, tadvIryaM; yatra kurvanti, tadadhikaraNaM; yadAkurvanti, sa kAlaH; yathA kurvanti, sa upAyaH; yat sAdhayanti, tat phalam||13||  
 
The activity of drugs is not due to its properties only, but their own intrinsic composition, properties and both combined together in particular time, on reaching a particular locus, with a particular mechanism and objective are also involved in the mode of action of drug. What they perform is karma (action), by means of which they act is veerya (potency), where they act is adhikarana (locus of action), when they act is kala (time), how they act is upaya (mechanism) and what they achieve is phalam (result). [13]
 
The activity of drugs is not due to its properties only, but their own intrinsic composition, properties and both combined together in particular time, on reaching a particular locus, with a particular mechanism and objective are also involved in the mode of action of drug. What they perform is karma (action), by means of which they act is veerya (potency), where they act is adhikarana (locus of action), when they act is kala (time), how they act is upaya (mechanism) and what they achieve is phalam (result). [13]

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