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{{#seo:

{{#seo:

|title=Neurological diseases  

|title=Neurological diseases  

|titlemode=append

|titlemode=append

|keywords= Principles, diagnosis, management, Neurological diseases,vata vyadhi, vata, pakshaghata, ardita, avarana, cerebrovascular accident, transient ischaemic attack, Ayurveda, treatment interventions, medical system healthcare, symbiohealth, charak samhita, caraka samhita, Indian system of medicine, pathogenesis of disease  

|keywords= Principles, diagnosis, management, Neurological diseases, vata vyadhi, vata, pakshaghata, ardita, avarana, cerebrovascular accident, transient ischemic attack, stroke, Ayurveda, treatment interventions, medical system healthcare, symbiohealth, charak samhita, caraka samhita, Indian system of medicine, pathogenesis of disease, alternative medicine, complementary medicine

|description= Principles of diagnosis and management of neurological diseases in Ayurveda are described.   

|description= Principles of diagnosis and management of neurological diseases in Ayurveda are described.   

|image=http://www.carakasamhitaonline.com/resources/assets/ogimgs.jpg

|image=http://www.carakasamhitaonline.com/resources/assets/ogimgs.jpg

|type=article

|type=article

}}

}}

'''Diagnosis and Management of Neurological Diseases in Ayurveda'''

'''Diagnosis and Management of Neurological Diseases in Ayurveda'''

 

<p style="text-align:justify;">This article is based on the lecture delivered by Prof. (Dr.) S.H. Acharya in Prof. M. S. Baghel Memorial Lecture Series on July 09, 2021.The video lecture can be accessed on the link of [https://fb.watch/8l9a6DVmz6/ facebook page.]

This article is based on the lecture delivered by Prof. (Dr.) S.H. Acharya in Prof. M. S. Baghel Memorial Lecture Series on July 09, 2021.

</p>

</div>

{{Infobox

{{Infobox

|title =  Contributors

|title =  Contributors

|label4 = Editors

|label4 = Editors

|data4 = Deole Y.S.², Anagha.S.²,Basisht G. ²  

|data4 = Deole Y.S.², Anagha.S.², Basisht G. ²  

|label5 = Affiliations

|label5 = Affiliations

|data5 = ¹Distingushed Professor, All India Institute of Ayurveda, New Delhi.

|data5 = ¹Distinguished Professor, All India Institute of Ayurveda, New Delhi.

 

²[[Charak Samhita Research, Training and Development Centre]], I.T.& R.A., Jamnagar, Gujarat, India   

²[[Charak Samhita Research, Training and Development Centre]], I.T.& R.A., Jamnagar, Gujarat, India   

|data6 = carakasamhita@gmail.com

|data6 = carakasamhita@gmail.com

|label7 = Date of first publication:

|label7 = Publisher

|data7 = July 28, 2021

|data7 = [[Charak Samhita Research, Training and Development Centre]], I.T.R.A., Jamnagar, India

|label8 = DOI

|label8 = Date of first publication:

|data8 = Under process

 

|label9 = DOI

|data9 = 10.47468/CSNE.2021.e01.s09.069

}}

}}

== [[Vata]] and Neurological Diseases==

== [[Vata]] and Neurological Diseases==

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<div style="text-align:justify;">  

Neurological diseases are generally considered under the umbrella of diseases of [[vata]] [[dosha]] (vata vyadhi). However, diseases of [[Vata]] does not limit to neurological disorders. Similarly, certain neuropathological conditions are beyond the limits of pure [[vata]] disorders.

Neurological diseases are generally considered under the umbrella of diseases of [[vata]] [[dosha]] (vata vyadhi). However, diseases of [[vata]] does not limit to neurological disorders. Similarly, certain neuropathological conditions are beyond the limits of pure [[vata]] disorders.

</div>

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===Physiological boundaries of [[Vata]] ===

===Physiological boundaries of [[vata]] ===

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[[Vata]] is an essential factor for the sustenance of life and cognitive functions. [Cha. Sa. [[Sutra Sthana ] 25/40]. [[Vata]] is responsible for all activities in living beings, and its derangement can result in many diseases and even fatality. [Cha. Sa. [[Sutra Sthana]] 17/ 118]

[[Vata]] is an essential factor for the sustenance of life and cognitive functions. [Cha. Sa. [[Sutra Sthana ] 25/40]. [[Vata]] is responsible for all activities in living beings, and its derangement can result in many diseases and even fatality. [Cha. Sa. [[Sutra Sthana]] 17/ 118]

All voluntary and involuntary body movements, including natural physiological impulses (somatic & psychosomatic), are executed by neural pathways. These activities with cranial nerve impulses are outcomes of activities of [[vata]].  Respiratory functions, cardiac and circulatory activities are invariably done by [[vata]]. All somatic systems and their regulatory functions and integration are governed or maintained by [[vata]].[ Cha. Sa. [[Sutra Sthana]] 12/ 8] It also controls and regulates the activities of the mind ([[manas]]). [ Cha. Sa. [[Sutra Sthana]] 12/ 8] The perception, cognition, and thought process is under the control of [[vata]].

All voluntary and involuntary body movements, including natural physiological impulses (somatic & psychosomatic), are executed by neural pathways. These activities with cranial nerve impulses are outcomes of activities of [[vata]].  Respiratory functions, cardiac and circulatory activities are invariably done by [[vata]]. All somatic systems and their regulatory functions and integration are governed or maintained by [[vata]].[ Cha. Sa. [[Sutra Sthana]] 12/ 8] It also controls and regulates the activities of the mind ([[manas]]). [Cha. Sa. [[Sutra Sthana]] 12/8] The perception, cognition, and thought process is under the control of [[vata]].

So, the vegetative nervous system, central nervous system or higher nervous system, brain behavior, and mental functions are all governed by [[Vata]] itself.

So, the vegetative nervous system, central nervous system or higher nervous system, brain-behavior, and mental functions are all governed by [[vata]] itself.

The physiology of [[vata]] cannot be limited to neurophysiology. Instead, it can be extended to molecular biology in addition to the neuronal or cellular functions.

The physiology of [[vata]] cannot be limited to neurophysiology. Instead, it can be extended to molecular biology in addition to the neuronal or cellular functions.

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The terms like sira (blood vessels), snayu (tendons) and kandara (ligaments) describe the pathology of seizures (akshepaka, dandaka) and palsies (ardita, pakshaghata). Their description in vata vyadhi confirms the connection of vata dosha disorders with the nervous system.  

The terms like sira (blood vessels), snayu (tendons) and kandara (ligaments) describe the pathology of seizures (akshepaka, dandaka) and palsies (ardita, pakshaghata). Their description in vata vyadhi confirms the connection of vata dosha disorders with the nervous system.  

===Head (shiras) :===

===Head (shiras) ===

The head is the most vital organ in the body (uttamanga). The roots of all the sensory and motor organs ([[indriya]]) are located in the head. [Cha. Sa. [[Sutra Sthana]] 17/12]

The head is the most vital organ in the body (uttamanga). The roots of all the sensory and motor organs ([[indriya]]) are located in the head. [Cha. Sa. [[Sutra Sthana]] 17/12]

Several vital points (marma) are located in the head. Any damage to these areas (marma sthana) can produce symptoms similar to neurological disturbances.  

Several vital points ([[Marma|marma]]) are located in the head. Any damage to these areas (marma sthana) can produce symptoms similar to neurological disturbances.  

The location of mind is described as between the top of the skull and palate by Acharya Bhela. It is precisely where the cortex and limbic system, i.e., the higher nervous system related to the functions of the mind is located.

The location of mind is described as between the top of the skull and palate by Acharya Bhela. It is precisely where the cortex and limbic system, i.e., the higher nervous system related to the functions of the mind is located.

In Ayurveda, more importance is given to functional aspects than the neuro-anatomical structures.

In [[Ayurveda]], more importance is given to functional aspects than the neuro-anatomical structures.

== Ayurvedic  terminologies resembling  neurological diseases ==

== Ayurvedic  terminologies resembling  neurological diseases ==

* Vepathu (Tremors)

* Vepathu (Tremors)

===Neuropsychotic conditions:===

===Neuropsychotic conditions ===

* Vishada (Depression)

* Vishada (Depression)

* Anavasthitha Chitta (fleeting thoughts)

* Anavasthitha Chitta (fleeting thoughts)

===Radiculopathies:===

===Radiculopathies===

 

It includes Gridhrasi (Sciatica), Khalli (twisting pain in

It includes Gridhrasi (Sciatica), Khalli (twisting pain in

the extremities), Vishwachi (shoulder pain), Apabahuka (frozen shoulder), Ansa shosha (atrophy of scapular muscles)

the extremities), Vishwachi (shoulder pain), Apabahuka (frozen shoulder), Ansa shosha (atrophy of scapular muscles)

== Diagnostic and Therapeutic approach in Ayurveda ==

== Diagnostic and Therapeutic approach in Ayurveda ==

=== Cerebrovascular accidents ===

=== Cerebrovascular accidents ===

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==== Incomplete stroke ====

==== Incomplete stroke ====

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The clinical manifestation of ‘ardita’ is described as either half of the entire body or half of the face affected by aggravated [[vata]] [[dosha]].[Cha. Sa.[[Chikitsa Sthana]] 28/42] So, ardita has a very similar clinical picture as that of pakshaghata (hemiplegia). However, a group of illnesses noted along with ‘ardita’ manifest in episodic form (vega). When the episodic event seizes, the patient is almost in normal state. Thus, a differential diagnosis between ardita and pakshaghata is chiefly relying on the transient nature of ardita [Chakrapani commentary, Cha. Sa. [[Chikitsa Sthana]] 28/38-42]

The clinical manifestation of ‘ardita’ is described as either half of the entire body or half of the face affected by aggravated [[vata]] [[dosha]].[Cha. Sa.[[Chikitsa Sthana]] 28/42]  

So, ardita simulates a transient ischemic attack or incomplete stroke, and pakshaghata simulates the condition of complete stroke. The difference in line of treatment for ardita and pakshaghata apparantly reflect the difference in their etiopathological context.  

So, ardita has a very similar clinical picture as that of pakshaghata (hemiplegia). However, a group of illnesses noted along with ‘ardita’ manifest in episodic form (vega). When the episodic event seizes, the patient is almost in normal state. Thus, a differential diagnosis between ardita and pakshaghata is chiefly relying on the transient nature of ardita [Chakrapani commentary, Cha. Sa. [[Chikitsa Sthana]] 28/38-42]

 

Thus, ardita simulates a transient ischemic attack or incomplete stroke, and pakshaghata simulates the condition of complete stroke. The difference in line of treatment for ardita and pakshaghata apparantly reflect the difference in their etiopathological context.  

'''Management of incomplete stroke'''

'''Management of incomplete stroke'''

[[Nasya]] therapy, if performed judicially in accordance with the classical procedure can produce noticeable results in ischaemic conditions. The position of the head shall be lowered from the table. Person in a supine sleeping position with hyper extended neck and head slightly hanging downward (head low position)]  

[[Nasya]] therapy, if performed judicially in accordance with the classical procedure can produce noticeable results in ischaemic conditions. The position of the head shall be lowered from the table. Person in a supine sleeping position with hyper extended neck and head slightly hanging downward (head low position)]  

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====Complete stroke====

====Complete stroke====

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<div style="text-align:justify;">  

When the hemorrhage happens at the area of mostly ner internal capsules, near the circle of Willis, huge edema develops around the area in the brain which is usually referred as peri -hemorrhagic edema. Furthermore, when oedema recedes, there will be some improvements in the signs and symptoms of a stroke. So, at this stage of edema, [[virechana]] works well. It was found to contribute significantly in reducing peri-hemorrhage edema.   

When the hemorrhage happens at the area of mostly ner internal capsules, near the circle of Willis, huge edema develops around the area in the brain which is usually referred as peri -hemorrhagic edema. Furthermore, when oedema recedes, there will be some improvements in the signs and symptoms of a stroke. So, at this stage of edema, [[virechana]] works well. It was found to contribute significantly in reducing peri-hemorrhage edema.   

The recent research on the management of stroke reveals that due to rapid onset, the primary injury of ICH is challenging to treat. Primary injury is followed by secondary injury in the peri hemorrhagic region over several days to weeks and provides a longer treatment window than the primary injury. It is important to minimize the direct effect of clot-related hydrostatic pressure. Clot removal and/or hyperosmolar therapy by mannitol etc. is indicated for the purpose.  

The recent research on the management of stroke reveals that due to rapid onset, the primary injury of ICH is challenging to treat. Primary injury is followed by secondary injury in the peri hemorrhagic region over several days to weeks and provides a longer treatment window than the primary injury. It is important to minimize the direct effect of clot-related hydrostatic pressure. Clot removal and/or hyperosmolar therapy by mannitol etc. is indicated for the purpose.  

A collection of molecules called the ‘complement system’ plays a crucial role in the body’s frontline defense against pathogens. But after a stroke, this system can trigger harmful inflammatory processes that damage the brain. Recent investigations in mice reveal that better outcomes can be achieved by addressing the immune response. It can be done by inhibiting its harmful effects immediately after stroke or promoting its ability to aid recovery.  

A collection of molecules called the ‘complement system’ plays a crucial role in the body’s frontline defense against pathogens. But after a stroke, this system can trigger harmful inflammatory processes that damage the brain. Recent investigations in mice reveal that better outcomes can be achieved by addressing the immune response. It can be done by inhibiting its harmful effects immediately after stroke or promoting its ability to aid recovery.<ref>New therapeutic approaches directed at the post-stroke immune response show promise in mice

So, [[Virechana]] could be a better supplement in Ayurveda clinics for steroids and diuretics to deal with cerebral inflammation. In addition, the mechanism of purification therapies(shodhana) could flush out untoward oxidant molecules generated during the phenomenon of stroke. This can set the immune mechanism to normalcy.

 

So, [[virechana]] could be a better supplement in Ayurveda clinics for steroids and diuretics to deal with cerebral inflammation. In addition, the mechanism of purification therapies(shodhana) could flush out untoward oxidant molecules generated during the phenomenon of stroke. This can set the immune mechanism to normalcy.

When it is established that there is infarction and complete death of the nerve cells in complete stroke, it is usually treated as incurable. However, several patients with hemorrhagic stroke have got complete improvement in symptoms after Ayurvedic treatment. The slow auto-healing of neighboring tissues of infarcted focal area, the concept of neuronal plasticity, sensory-motor integration in the brain etc., can be the reasons behind these recoveries.

When it is established that there is infarction and complete death of the nerve cells in complete stroke, it is usually treated as incurable. However, several patients with hemorrhagic stroke have got complete improvement in symptoms after Ayurvedic treatment. The slow auto-healing of neighboring tissues of infarcted focal area, the concept of neuronal plasticity, sensory-motor integration in the brain etc., can be the reasons behind these recoveries.

==Interactive Session==

==Interactive Session==

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<div style="text-align:justify;">  

1) Which is the best, effective, and safe Ayurvedic medicine for [[virechana]] in acute cerebrovascular stroke? Please share your experiences.

'''1) Which is the best, effective, and safe Ayurvedic medicine for [[virechana]] in acute cerebrovascular stroke? Please share your experiences.'''

Sneha yukta [[virechana]] (therapeutic purgation with unctuous substance) is mainline of treatment. Medicines like eranda taila (castor oil) or castor seeds (eranda beeja) processed in milk with a small amount of cow’s urine (gomutra) for [[virechana]] in stroke patients. We can select the formulations for [[virechana]] according to the pathogenesis (samprapti) also. But, the strength (bala) of the patient should be considered with prime importance.

Sneha yukta [[virechana]] (therapeutic purgation with unctuous substance) is mainline of treatment. Medicines like eranda taila (castor oil) or castor seeds (eranda beeja) processed in milk with a small amount of cow’s urine (gomutra) for [[virechana]] in stroke patients. We can select the formulations for [[virechana]] according to the pathogenesis (samprapti) also. But, the strength (bala) of the patient should be considered with prime importance.

2) What can be a standard research protocol for the management of neurological disorders because the conditions are highly person-specific?

'''2) What can be a standard research protocol for the management of neurological disorders because the conditions are highly person-specific?'''

Ans: It is tough to answer the question because we have to develop such a protocol purely based on Ayurvedic principles. We have to re-modify the trials which had been conducted in pharmacological laboratories with modern standards. We have to re-design the clinical trials by keeping the essence of [[Ayurveda]] in it. At present, we cannot give such a single protocol. However, the development of such an Ayurvedic research protocol incorporating the necessary modern parameters also is under progress. In precise, it cannot be just clinical Drug Trial protocol but to bring the holistic concept of [[Ayurveda]] approach in research also.  

Ans: It is tough to answer the question because we have to develop such a protocol purely based on Ayurvedic principles. We have to re-modify the trials which had been conducted in pharmacological laboratories with modern standards. We have to re-design the clinical trials by keeping the essence of [[Ayurveda]] in it. At present, we cannot give such a single protocol. However, the development of such an Ayurvedic research protocol incorporating the necessary modern parameters also is under progress. In precise, it cannot be just clinical Drug Trial protocol but to bring the holistic concept of [[Ayurveda]] approach in research also.  

</div>

</div>

==References:==

==References:==