Changes

''Anuvasana'' or ''snehapana'' therapy is indicated on ninth day after cleansing processes. This duration of gap includes seven days of post therapeutic measures and one day of rest. Immediately after cleansing, the digestive power is reduced and it improves gradually in seven days. This gap of total eight days is very much necessary to regain the normal functioning of digestive components in the gastrointestinal tract. Mucosal membrane is one such component of digestive tract that establishes a barrier between external environments and the internal milieu. Normal well formed healthy mucosa is responsible for nutrient absorption and waste secretion, which require a selectively permeable barrier. These functions place the mucosal epithelium at the centre of interactions between the mucosal immune system and luminal contents, including dietary antigens and microbial products <ref> Turner JR, Intestinal mucosal barrier function in health and disease, Nature Reviews and Immunology. 2009 Nov;9(11):799-809 </ref>. Thus in view of regeneration of new healthy mucosal barrier this duration of gap may play a prime role.

''Anuvasana'' or ''snehapana'' therapy is indicated on ninth day after cleansing processes. This duration of gap includes seven days of post therapeutic measures and one day of rest. Immediately after cleansing, the digestive power is reduced and it improves gradually in seven days. This gap of total eight days is very much necessary to regain the normal functioning of digestive components in the gastrointestinal tract. Mucosal membrane is one such component of digestive tract that establishes a barrier between external environments and the internal milieu. Normal well formed healthy mucosa is responsible for nutrient absorption and waste secretion, which require a selectively permeable barrier. These functions place the mucosal epithelium at the centre of interactions between the mucosal immune system and luminal contents, including dietary antigens and microbial products <ref> Turner JR, Intestinal mucosal barrier function in health and disease, Nature Reviews and Immunology. 2009 Nov;9(11):799-809 </ref>. Thus in view of regeneration of new healthy mucosal barrier this duration of gap may play a prime role.

After ''niruha'', type of medicated enema the unctuous enema is indicated on the same day in the evening for the pacification ''vata'' that is remained in the gut even after removal by ''niruha'' or to pacify ''vata'' that is produced due to possible overdose of ''niruha''. Also as per modern perspectives it is possible that due to ''niruha'' type of medicated enema the colon gets cleared providing minimal barrier for absorption and due to increased permeability on virtue of transient inflammation, the transmucosal entry of fats of unctuous enema is facilitated.

After ''niruha'', type of medicated enema the unctuous enema is indicated on the same day in the evening for the pacification ''vata'' that is remained in the gut even after removal by ''niruha'' or to pacify ''vata'' that is produced due to possible overdose of ''niruha''. Also as per modern perspectives it is possible that due to ''niruha'' type of medicated enema the colon gets cleared providing minimal barrier for absorption and due to increased permeability on virtue of transient inflammation, the transmucosal entry of fats of unctuous enema is facilitated <ref>Hollander, Daniel, ''Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives: A Possible Etiologic Factor'', Annals of  Internal Medicine, 1986;105(6):883-885</ref>.

==== Number and sequence of unctuous and ''niruha'' type of enema (verse 23-25) ====

==== Number and sequence of unctuous and ''niruha'' type of enema (verse 23-25) ====