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There is always an inter-relationship between ''avayava'' (organ) and ''avayavi'' (part of organ) or ''ashraya''(seat) and ''ashrayi'' (seated). Either of the one has an impact on the other, hence if ''grahaniavayava'' is in normal state then ''agni'' the ''avayavi'' functions normally and vice versa also holds true, whereas if ''dusti'' of ''grahani'' takes place ''agni vaishamyata'' (imbalance) is seen e.g. ileitis, wherein digestion is hampered. ''Grahani'' is the seat for ''jatharagni''. (Ca.Ci.15 /56) ''Agni'' is responsible for ''ayu'' (longevity of life), ''varna'' (complexion), ''bala'' (strength), ''svasthya'' (health), ''utsaha'' (enthusiasm), ''upachaya'' (proper metabolism), ''prabha'' (glow) and ''oja'' (core energy). ''Prakrita agni'' (normal digestive power) is essential for long and healthy life while, vitiated ''agni'' is responsible for ''roga avastha''(disease).(Ca. Ci. 15/3-4)  
 
There is always an inter-relationship between ''avayava'' (organ) and ''avayavi'' (part of organ) or ''ashraya''(seat) and ''ashrayi'' (seated). Either of the one has an impact on the other, hence if ''grahaniavayava'' is in normal state then ''agni'' the ''avayavi'' functions normally and vice versa also holds true, whereas if ''dusti'' of ''grahani'' takes place ''agni vaishamyata'' (imbalance) is seen e.g. ileitis, wherein digestion is hampered. ''Grahani'' is the seat for ''jatharagni''. (Ca.Ci.15 /56) ''Agni'' is responsible for ''ayu'' (longevity of life), ''varna'' (complexion), ''bala'' (strength), ''svasthya'' (health), ''utsaha'' (enthusiasm), ''upachaya'' (proper metabolism), ''prabha'' (glow) and ''oja'' (core energy). ''Prakrita agni'' (normal digestive power) is essential for long and healthy life while, vitiated ''agni'' is responsible for ''roga avastha''(disease).(Ca. Ci. 15/3-4)  
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In this chapter, Charaka describes formation of body tissues in detail with the role of ahara which is supplied continuously to maintain homeostasis. Vyāna vāta is promoter of rasa raktādi circulation.( Ca. Ci. 15/36)  It transports rasa raktādi drava dhātu throughout body continuously and as per metabolic demand. This explanation shows that closed circulation in human was known to Caraka.
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In this chapter, Charaka describes formation of body tissues in detail with the role of ''ahara'' which is supplied continuously to maintain homeostasis. ''Vyana vata'' is promoter of ''rasa raktadi'' circulation.( Ca. Ci. 15/36)  It transports ''rasa raktadi drava'' ''dhatu'' throughout body continuously and as per metabolic demand. This explanation shows that closed circulation in human was known to Charaka.
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Grahaṇī is prime place where digestion and absorption of ahara rasa takes place. Āhara rasa provides nutrition for the rasādi sapta dhātu, along-with three sharirik dōṣha and three manasik dōṣha. Nourishment of satva, raja and tama is influenced by sātvika, rājasik and tāmasik ahāra. Tāmasika and rājasik ahāra suppresses satva guna thereby causing alpa satva in individual, a common predisposing factor of psychiatric disorders for e.g. alpa satva as mentioned in unmāda (Ca. Ci. 9/5)In vātaja grahaṇīvyādhishankā (feeling of suffering from disease) manifests in patients with alpa satva.  
 
Grahaṇī is prime place where digestion and absorption of ahara rasa takes place. Āhara rasa provides nutrition for the rasādi sapta dhātu, along-with three sharirik dōṣha and three manasik dōṣha. Nourishment of satva, raja and tama is influenced by sātvika, rājasik and tāmasik ahāra. Tāmasika and rājasik ahāra suppresses satva guna thereby causing alpa satva in individual, a common predisposing factor of psychiatric disorders for e.g. alpa satva as mentioned in unmāda (Ca. Ci. 9/5)In vātaja grahaṇīvyādhishankā (feeling of suffering from disease) manifests in patients with alpa satva.  
  

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