From Charak Samhita
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The word is formed by union of four words like Asatmya(unsuitable) + Indriya(sense or locomotor organs) + Artha (objects) + samyoga (union). Thus it means improper or unsuitable union of sense and locomotor organs with their objects.
This is one of the three fundamental causes of disease. (Cha.Su.11/43)

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