Talk:Rasna: Difference between revisions

|keywords= *rasna, Pluchea lanceolata Oliv., Indian camphor weed* Therapeutic use, herbs, researches on dravya, Charak Samhita, Dravyaguna, carakasamhitaonline, carakasamhita, caraka samhita, Ayurveda, Charak Samhita English translation, ancient Ayurveda text, Indian system of medicine, Ayurveda, Charak, Charaka Samhita, agnivesha, atreya, gopal basisht, yogesh deole, charak samhita wikipedia edition, charak samhita new edition, charaka samhita new edition, carak samhita new edition, caraka samhita new edition, research on charak samhita, text book charak samhita, fundamental principles of ayurveda, basic concepts of ayurveda,

 

|data2 = Pluchea lanceolata Oliv.

|label3 = Family

|data3 = Asteraceae (Composite)

|label4 = Availability

|label6 = Year of publication  

|data6 = 2026

|label7 = Publisher  

|data7 = [[Charak Samhita Research, Training and Skill Development Centre]]

|label8 = DOI  

|data8 = Awaited

 

== English name ==

 

 

* Conyza rubra Buch.-Ham. ex DC.

 

 

 

== Varieties ==

Mentioned 3 types<ref name="Tripathi2006">Dr. Indradev Tripathi , Raja Nighantu of pandit Narhari, ed.2006, Chaukhambha Krishnadas Academy, Varanasi, pippalyadi varga 81</ref>

== Ayurvedic Pharmacological Properties ==

|+ Properties

! Sr.no. !! Pharmacological criteria !! Properties

| 1 || Taste (rasa) || Bitter (tikta)

| 2 || Potency (veerya) || Hot (ushna)

| 3 || Post digestion effect (vipaka) || Pungent (katu)

| 4 || Qualities (guna) || Heavy (guru)

| 5 || Actions (karma) || Pacify Kapha and Vata

|}

 

== Reference in Charak Samhita and its actions ==

{| class="wikitable"

|+ Herbs and their activities

! Sr.no. !! Reference in Charak Samhita !! Activity

| 1 || Cha.Sa. [[Sutra Sthana]] 4/9(26) || Anuvasanopag mahakashay (unctuous enema)

| 2 || Cha.Sa. [[Sutra Sthana]] 25/40 || Agrya Sangraha

| 3 || Cha.Sa. [[Sutra Sthana]] 27/107 || Shaka Varga (Class of vegetables, mentioned as Sheyasi)

| 4 || Cha.Sa. [[Vimana Sthana]] 8/135 || Vamana dravyani (List of medicines used in therapeutic emesis)

| 5 || Cha.Sa. [[Chikitsa Sthana]] 3/250 || As an ingredient of Jeevantyadi anuvasana basti

| 6 || Cha.Sa. [[Chikitsa Sthana]] 3/267 || As an ingredient of Agurvadi taila

| 7 || Cha.Sa. [[Chikitsa Sthana]] 12/72 || As an Unmardan dravya in Kaphaj Shvayathu

| 8 || Cha.Sa. [[Chikitsa Sthana]] 13/110 || In treatment of Udara roga (for parisheka)

| 9 || Cha.Sa. [[Chikitsa Sthana]] 14/43 || Used in swedana kriya (fomentation)

| 10 || Cha.Sa. [[Chikitsa Sthana]] 14/63 || As an ingredient of traushnadi churna

| 11 || Cha.Sa. [[Chikitsa Sthana]] 17/96 || Used in yusha preparation for hikka svasa

| 12 || Cha.Sa. [[Chikitsa Sthana]] 18/58 || As an ingredient of agastya haritaki leha

| 13 || Cha.Sa. [[Chikitsa Sthana]] 26/82 || As an ingredient of Punarnavadi taila for vataja hrudroga

| 14 || Cha.Sa. [[Chikitsa Sthana]] 28/165 || As an ingredient of Rasna taila

| 15 || Cha.Sa. [[Chikitsa Sthana]] 30/60 || As an ingredient of Guduchyadi taila for Vataja yoni roga

 

 

 

 

 

 

 

 

A comprehensive review of the plant's chemistry and pharmacology records anti-inflammatory and anti-arthritic activity, along with analgesic, laxative and antipyretic activities, and attributes the anti-inflammatory effect mainly to its triterpenoids. This agrees with the classical use of Rasna in Amavata and Vatavyadhi, though the review-level evidence is not a substitute for clinical trials.<ref name="Srivastava2012"/>

 

=== Immunosuppressive and immunomodulatory activity ===

In Balb/c mice, a 50% ethanolic leaf extract reduced the humoral antibody response and delayed-type hypersensitivity, and also decreased phagocytosis and delayed skin-graft rejection. Its chloroform fraction (25–200 mg/kg, orally) significantly suppressed CD8+/CD4+ T-cell surface markers and the intracellular Th1 cytokines IL-2 and IFN-γ. The authors concluded that the plant acts by inhibiting Th1 cytokines, which is relevant to autoimmune joint disease.<ref name="Bhagwat2010">Bhagwat DP, Kharya MD, Bani S, Kaul A, Kour K, Chauhan PS, Suri KA, Satti NK. Immunosuppressive properties of Pluchea lanceolata leaves. Indian Journal of Pharmacology. 2010;42(1):21–26. doi:10.4103/0253-7613.62405</ref>

 

 

 

=== Anti-asthmatic activity (Swasa, Kasa) ===

In isolated guinea pig tracheal chain, the ethyl acetate fraction of the leaf extract (100 µg/mL) significantly reduced histamine-induced contraction; the maximum contraction fell from 100% in controls to 57.81 ± 1.22%. This is an in vitro finding and has not been confirmed in clinical studies.<ref name="Arora2011">Arora R, Gill NS, Dhingra VK, Rana AC. Evaluation of anti-asthmatic potential of ethyl acetate fraction of Pluchea lanceolata. Pharmacologyonline. 2011;2:1126–1133.</ref>

 

The hexane extract and taraxasterol acetate showed antimalarial activity against ''Plasmodium falciparum'' in vitro and ''P. berghei''-infected mice in vivo. Taraxasterol acetate also inhibited pro-inflammatory cytokines and raised blood glucose and haemoglobin levels in infected mice. No synergy with chloroquine was seen.<ref name="Mohanty2013">Mohanty S, Srivastava P, Maurya AK, Cheema HS, Shanker K, Dhawan S, Darokar MP, Bawankule DU. Antimalarial and safety evaluation of Pluchea lanceolata (DC.) Oliv. & Hiern: in-vitro and in-vivo study. Journal of Ethnopharmacology. 2013;149(3):797–802. PMID: 23954323</ref>

 

 

* '''Toxicity:''' The hexane extract was reported as non-toxic at higher concentrations in in vitro and in vivo safety evaluation.<ref name="Mohanty2013"/> No formal human safety data were found.

* '''Precautions (inference, not from a cited study):''' Because the extract showed immunosuppressive activity in mice, caution is reasonable in patients taking immunosuppressant drugs. Data on use in pregnancy, lactation and children are lacking, and people with known sensitivity to the Asteraceae (Compositae) family should be watchful for allergic reactions.

 

|+ Therapeutic Applications of ''Pluchea lanceolata'' (preclinical evidence)

| '''Amavata / joint inflammation''' || Anti-inflammatory and anti-arthritic activity; Th1 cytokine suppression || Review; mouse study

| '''Vatavyadhi (neurological disorders)''' || Reduced TNF-α, IFN-γ and IL-6 (taraxasterol); acetylcholinesterase inhibition (volatile oil) || Cell culture; ex vivo

| '''Swasa / Kasa (asthma, cough)''' || Reduced histamine-induced tracheal contraction || Isolated guinea pig trachea

| '''Jvara (fever, malaria-like fever)''' || Antimalarial activity of hexane extract and taraxasterol acetate || In vitro; mouse model

| '''Oxidative stress / DNA damage''' || Restored renal antioxidant enzymes and DNA integrity || Mouse model

== References ==

<ref name="Khan2010">Khan S, Rawat R, Rawat AKS, Shirwaikar A. A report on the quality control parameters of aerial parts of Pluchea lanceolata (DC.) Oliv. & Hiern, Asteraceae. Revista Brasileira de Farmacognosia. 2010;20. Available from: https://www.scielo.br/j/rbfar/a/vpXGbMFB45qRpt6V76tyhQn/?lang=en</ref>

<ref name="Srivastava2015">Srivastava P, Jyotshna, Chanda D, Shanker K. Chemical characterization and acetylcholinesterase inhibition potential of volatile components of aerial parts of Pluchea lanceolata (DC.) Oliv. & Hiern. Records of Natural Products. 2015;9(4):586–591.</ref>

<ref name="Bhagwat2010">Bhagwat DP, Kharya MD, Bani S, Kaul A, Kour K, Chauhan PS, Suri KA, Satti NK. Immunosuppressive properties of Pluchea lanceolata leaves. Indian Journal of Pharmacology. 2010;42(1):21–26. doi:10.4103/0253-7613.62405</ref>

<ref name="Srivastava2014">Srivastava P, Mohanty S, Bawankule DU, Khan F, Shanker K. Effect of Pluchea lanceolata bioactives in LPS-induced neuroinflammation in C6 rat glial cells. Naunyn-Schmiedeberg's Archives of Pharmacology. 2014;387(2):119–127.</ref>

<ref name="Arora2011">Arora R, Gill NS, Dhingra VK, Rana AC. Evaluation of anti-asthmatic potential of ethyl acetate fraction of Pluchea lanceolata. Pharmacologyonline. 2011;2:1126–1133.</ref>