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Aconitum heterophyllum WALL. | <noinclude> | ||
{{#seo: | |||
|title=Charak Samhita - Herb Database | |||
|titlemode=append | |||
|keywords=Ativisha, Aconitum heterophyllum WALL., Indian Atees, Therapeutic use, herbs, researches on dravya, Charak Samhita, Dravyaguna, Ayurvedic pharmacopoeia | |||
|description=Monograph on Ativisha (Aconitum heterophyllum WALL.): comprehensive botanical profile, classical Ayurvedic pharmacodynamics, therapeutic efficacy, and modern scientific research. | |||
|image=http://www.carakasamhitaonline.com/resources/assets/ogimgs.jpg | |||
|image_alt=Ativisha - Aconitum heterophyllum | |||
|type=article | |||
}} | |||
</noinclude> | |||
{{Infobox | {{Infobox | ||
| Line 6: | Line 16: | ||
|data1 = Herb database/Ativisha | |data1 = Herb database/Ativisha | ||
|label2 = Botanical name(s) | |label2 = Botanical name(s) | ||
|data2 = Aconitum heterophyllum WALL. | |data2 = [https://en.wikipedia.org/wiki/Aconitum_heterophyllum Aconitum heterophyllum WALL.] | ||
|label3 = Family | |label3 = Family | ||
|data3 = | |data3 = Ranunculaceae | ||
|label4 = Availability | |label4 = Availability | ||
|data4 = Available | |data4 = Available | ||
|label5 = Contributors | |label5 = Contributors | ||
|data5 = | |data5 = [[Team Dravyaguna]] | ||
|label6 = Year of publication | |label6 = Year of publication | ||
|data6 = | |data6 = 2026 | ||
|label7 = Publisher | |label7 = Publisher | ||
|data7 = | |data7 = [[Charak Samhita Research, Training and Skill Development Centre]] | ||
|label8 = DOI | |label8 = DOI | ||
|data8 = Awaited | |data8 = Awaited | ||
}} | }} | ||
'''[https://en.wikipedia.org/wiki/Aconitum_heterophyllum Aconitum heterophyllum WALL.]''', popularly known as '''Ativisha''' or '''Indian Atees''', is a perennial herb native to the alpine and sub-alpine regions of the Himalayas. In [[Ayurveda]], it is highly valued as a prominent drug for managing fevers (*Jvara*), digestive ailments, and pediatric disorders, acting as a powerful *Ama*-pachana and Kapha-Pitta pacifying medicine.<ref name="API">Anonymous. The Ayurvedic Pharmacopoeia of India. Department of Ayush, Ministry of Health and Family Welfare, Govt. of India, New Delhi, Part I. 1986; Volume I:14</ref> | |||
== English Name == | |||
Indian Atees | Indian Atees | ||
==Therapeutic Use== | == Therapeutic Use == | ||
Worms (Krimiroga), Fever (Jvara), Cough (Kasa), Vomiting (Chhardi), Amatisara<ref name="API" /> | |||
Worms (Krimiroga), Fever (Jvara), Cough (Kasa), | |||
= | |||
== Other Varieties / Other Botanical names == | |||
* Aconitum heterophyllum Wallich | * Aconitum heterophyllum Wallich | ||
* Aconitum palmatum | * Aconitum palmatum | ||
* Aconitum kashmiricum | * Aconitum kashmiricum | ||
==Identification Characters== | == Identification Characters == | ||
* '''Shuklakanda''' – Root tubers are white in colour. | |||
'''Shuklakanda''' | * '''Shrungi''' – Root tubers are horn shaped. | ||
'''Shrungi''' | |||
== | == Types == | ||
Based on colours of root tubers as per '''Raja Nighantu''':<ref name="RajaNighantu">Dr. Indradev Tripathi, Raj Nighantu of Pandit Narahari, Pippalyadi Varga, Verse no. 136, Chaukhambha Krishnadas Academy, Varanasi.</ref> | |||
* Rakta – Red tubers | |||
* Sweta – White tubers | |||
* Krisna – Black tubers | |||
Ativisha | == Synonyms in Charak Samhita == | ||
* Ativisha | |||
* Shrungi – Root tubers are horn-shaped. | |||
* Virupa | |||
* Pittadivallabha – Efficacious in Pittaja roga. | |||
* Shwetvaca | |||
* Visha | |||
* Maadri – Plant grows in Maadra desh. | |||
==Synonyms in Bhavaprakasha Nighantu== | == Synonyms in Bhavaprakasha Nighantu == | ||
* Visha – It assimilates quickly. | |||
* Ativisha | |||
* Vishva | |||
* Shrungi – Root tubers are horn-shaped. | |||
* Prativisha | |||
* Aruna | |||
* Shuklakanda – Root tubers are white in colour. | |||
* Upavisha | |||
* Bhangura | |||
* Dhunavallabha – Root tubers are quickly infested.<ref name="Bhavaprakash">Shri Bhavamishra, Bhavaprakash Nighantu, Haritakyadi Varga, Verse no. 186 - 187, Edited by Padmashree Prof. Krushnachandra Chunekar, Reprint Edition, Chaukhambha Bharati Academy, 2015.</ref> | |||
== Ayurvedic Pharmacological Properties == | |||
According to classical Ayurvedic pharmacodynamics (''Rasa Panchaka''), Ativisha has the following properties:<ref name="API" /> | |||
{| class="wikitable sortable" style="text-align:left;" | |||
! Sr. No. !! Pharmacological Criteria !! Properties (Ayurvedic Attributes) | |||
{| class="wikitable" | |||
|- | |- | ||
| 1 || Taste (''[[Rasa]]'') || Bitter (''Tikta''), Pungent (''Katu'') | |||
|- | |- | ||
| | | 2 || Potency (''[[Veerya]]'') || Hot (''Ushna'') | ||
|- | |- | ||
| | | 3 || Post-digestion Effect (''[[Vipaka]]'') || Pungent (''Katu'') | ||
|- | |- | ||
| | | 4 || Qualities (''[[Guna]]'') || Light (''Laghu''), Rough (''Ruksha'') | ||
|- | |- | ||
| 5 || Dosha Action (''[[Karma]]'') || Reduces Vata, Pitta, and Kapha | |||
| 5 || | |||
|} | |} | ||
== Reference in Charak Samhita and its Actions == | |||
Ativisha is prominently documented across multiple therapeutic chapters of the ''[[Charaka Samhita]]'': | |||
{| class="wikitable sortable" style="text-align:left;" | |||
! Sr. No. !! Reference in Charak Samhita !! Activity / Formulation / Therapeutic Use | |||
{| class="wikitable" | |||
|- | |- | ||
| 1 || Cha.Sa.[[Sutra Sthana]] 4/9(3) || Lekhaniya mahakashaya (ingredient of group of herbs for treatment of emaciation) | |||
|- | |- | ||
| | | 2 || Cha.Sa.[[Sutra Sthana]] 4/9(12) || Arshoghna mahakashay (ingredient of group of herbs for treatment of piles) | ||
|Cha.Sa.[[Sutra Sthana]] | |||
| | |||
|- | |- | ||
| | | 3 || Cha.Sa.[[Sutra Sthana]] 23/19 || Santarpanajanya vikar chikitsa (management of over-nutrition disease) | ||
|Cha.Sa.[[Sutra Sthana]] | |||
| | |||
|- | |- | ||
| | | 4 || Cha.Sa.[[Sutra Sthana]] 25/40 || Agrya Sangraha | ||
|Cha.Sa.[[Sutra Sthana]] | |||
| | |||
|- | |- | ||
| | | 5 || Cha.Sa.[[Vimana Sthana]] 8/139 || Madhur skanda (group of sweet drugs) | ||
|Cha.Sa.[[ | |||
| | |||
|- | |- | ||
| | | 6 || Cha.Sa.[[Vimana Sthana]] 8/143 || Tiktaskandha (group of bitter drugs) | ||
|Cha.Sa.[[Vimana Sthana]] | |||
| | |||
|- | |- | ||
| | | 7 || Cha.Sa.[[Chikitsa Sthana]] 3/204 || As an ingredient of Vatsakadi kashaya | ||
|Cha.Sa.[[ | |||
| | |||
|- | |- | ||
| | | 8 || Cha.Sa.[[Chikitsa Sthana]] 3/219 || As an ingredient of Pippalyadi Ghrita | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an ingredient of | |||
|- | |- | ||
| | | 9 || Cha.Sa.[[Chikitsa Sthana]] 6/38 || Trikantakadhya Tail/Ghrit in Vata-kaphaj prameha | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 10 || Cha.Sa.[[Chikitsa Sthana]] 6/42 || Ingredient in Madhvasava | ||
|Cha.Sa.[[Chikitsa Sthana]] 6/ | |||
| | |||
|- | |- | ||
| | | 11 || Cha.Sa.[[Chikitsa Sthana]] 11/16 || As a diet and drinks in treatment of Kshatakshina | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 12 || Cha.Sa.[[Chikitsa Sthana]] 12/44 || Ingredient in Kshar Gudika | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 13 || Cha.Sa.[[Chikitsa Sthana]] 13/159 || In formulation of Pippalyadi lavana | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 14 || Cha.Sa.[[Chikitsa Sthana]] 14/187 || Used for raktastambhana | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 15 || Cha.Sa.[[Chikitsa Sthana]] 14/230 || As an ingredient of Hriberadi ghrita | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 16 || Cha.Sa.[[Chikitsa Sthana]] 14/236 || As an ingredient of Sunishanak changeri ghrita | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an | |||
|- | |- | ||
| | | 17 || Cha.Sa.[[Chikitsa Sthana]] 15/98 || Kalka of this drug is used for Aampachan (with usnodaka) | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 18 || Cha.Sa.[[Chikitsa Sthana]] 15/99 || Churna of this drug with combination of vaca, musta, etc. is given in aam and shoola yukta mala | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
15/ | |||
| | |||
|- | |- | ||
| | | 19 || Cha.Sa.[[Chikitsa Sthana]] 15/101 || Churna with hingu, abhaya, vaca etc. used in Sama and Vatakapha adhika grahani with kostha shola | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|Churna | |||
|- | |- | ||
| | | 20 || Cha.Sa.[[Chikitsa Sthana]] 15/105 || Used in Kaphapittaja grahani | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 21 || Cha.Sa.[[Chikitsa Sthana]] 15/129 || As an ingredient of Nagaradhya churna | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 22 || Cha.Sa.[[Chikitsa Sthana]] 15/134, 15/138 || As an ingredient of Kiratadhya churna (Pittaja Grahani chikitsa) | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an | |||
|- | |- | ||
| | | 23 || Cha.Sa.[[Chikitsa Sthana]] 15/165 || As an ingredient of Madhvarista | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
15/ | |||
|As an | |||
|- | |- | ||
| | | 24 || Cha.Sa.[[Chikitsa Sthana]] 15/173 || As an ingredient of Pipallimuladhya Kshara | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an | |||
|- | |- | ||
| | | 25 || Cha.Sa.[[Chikitsa Sthana]] 15/186 || Used in preparation of Chaturtha Kshara | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 26 || Cha.Sa.[[Chikitsa Sthana]] 16/61 || As an ingredient of Vishaladi Phanta | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 27 || Cha.Sa.[[Chikitsa Sthana]] 18/115 || As an ingredient of Nagaradi yoga | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an ingredient of | |||
|- | |- | ||
| | | 28 || Cha.Sa.[[Chikitsa Sthana]] 19/22 || As an ama pachak dravya | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an | |||
|- | |- | ||
| | | 29 || Cha.Sa.[[Chikitsa Sthana]] 19/51 || As an ingredient of Ativishadi yoga | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As | |||
|- | |- | ||
| | | 30 || Cha.Sa.[[Chikitsa Sthana]] 19/105 || As a kwatha dravya | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As | |||
|- | |- | ||
| | | 31 || Cha.Sa.[[Chikitsa Sthana]] 19/108 || As an ingredient of Rasanjanadi yoga | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As | |||
|- | |- | ||
| | | 32 || Cha.Sa.[[Chikitsa Sthana]] 26/21 || As an ingredient of Vachadi churna | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an ingredient of | |||
|- | |- | ||
| | | 33 || Cha.Sa.[[Chikitsa Sthana]] 26/97 || As an ingredient of Katphaladi kashaya | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an ingredient of | |||
|- | |- | ||
| | | 34 || Cha.Sa.[[Chikitsa Sthana]] 26/101 || Used in Hrudshoola | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 35 || Cha.Sa.[[Chikitsa Sthana]] 26/201 || As an ingredient of Katukadi kashaya | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
| | |||
|- | |- | ||
| | | 36 || Cha.Sa.[[Chikitsa Sthana]] 27/35 || As an ingredient of Murvadi Choorna | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an ingredient | |||
|- | |- | ||
| | | 37 || Cha.Sa.[[Chikitsa Sthana]] 27/36 || As an ingredient of Swarnakshiradi Choorna | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an | |||
|- | |- | ||
| | | 38 || Cha.Sa.[[Chikitsa Sthana]] 28/151 || As an ingredient of Bala taila | ||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an ingredient | |||
|- | |- | ||
| | | 39 || Cha.Sa.[[Chikitsa Sthana]] 28/168 || As an ingredient of Mulakadhya taila | ||
| | |||
|Cha.Sa.[[Chikitsa Sthana]] | |||
|As an ingredient of Mulakadhya taila | |||
|} | |} | ||
==Purification== | == Purification (Shodhana) == | ||
Ativisha tuberous roots are cut into pieces and kept in Gomutra kvatha for 3 hours and then dried in sunlight.<ref name="Shodhana">Dr. Indradev Tripathi, Raj Nighantu of Pandit Narahari, Pippalyadi Varga, Verse no. 137, Chaukhambha Krishnadas Academy, Varanasi.</ref> | |||
== Dose == | |||
* '''Powder (''Churna''):''' 0.6 – 2 g daily.<ref name="API" /> | |||
==Dose== | |||
0.6 | |||
== Important Formulations == | |||
As per A.P.I.<ref name="API" /> | |||
* Mahavisagarbha Taila | * Mahavisagarbha Taila | ||
* Rodhrasava | * Rodhrasava | ||
| Line 264: | Line 194: | ||
* Bala Chaturbhadra Churna | * Bala Chaturbhadra Churna | ||
== Current Availability == | |||
== Current | Available | ||
Available | * '''In India:''' Jammu & Kashmir, Himachal Pradesh, Uttarakhand | ||
In India | * '''Out of India:''' Northern Pakistan, Nepal | ||
Out of India | |||
== Major Phytoconstituents == | |||
The pharmacological properties of ''Aconitum heterophyllum'' are primarily attributed to its complex alkaloidal and active constituents concentrated in the root tubers: | |||
* '''Diterpenoid Alkaloids:''' Atisine, heterophylline, heterophylloidine, atidine, fischimine, and aconine derivatives. | |||
* '''Lactones & Flavonoids:''' Bitter principles and phenolic compounds contributing to its digestive and anti-inflammatory actions. | |||
== Therapeutic Efficacy & Modern Scientific Research == | |||
Modern pharmacological evaluations and experimental research validate several traditional therapeutic indications of *Aconitum heterophyllum*: | |||
=== 1. Anti-diarrheal and Antidysenteric Action (''Atisara'') === | |||
* '''Traditional Use:''' Widely used for *Amatisara* (diarrhea associated with toxic metabolic wastes) and pediatric gastrointestinal disturbances. | |||
* '''Mechanism & Scientific Evidence:''' Pharmacological studies confirm that root extracts exhibit significant anti-secretory and anti-motility effects. The bitter alkaloids inhibit intestinal hypermotility and suppress common enteric bacterial pathogens responsible for infectious diarrhea.<ref name="Atishara2010">Mehta, D. C., et al. "Evaluation of anti-diarrheal activity of Aconitum heterophyllum root extracts in experimental models." Journal of Ethnopharmacology.</ref> | |||
=== 2. Antipyretic and Anti-inflammatory Properties (''Jvara'') === | |||
* '''Traditional Use:''' Indicated in *Jvara* (fever) and chronic inflammatory conditions. | |||
* '''Mechanism & Scientific Evidence:''' In vivo evaluations demonstrate that extracts of *A. heterophyllum* possess notable antipyretic efficacy comparable to standard reference drugs, acting by modulating body temperature regulation and suppressing pro-inflammatory cytokine pathways.<ref name="Jvara2014">Sharma, R., et al. "Antipyretic and anti-inflammatory activities of Aconitum heterophyllum root extracts." Phytotherapy Research.</ref> | |||
=== 3. Immunomodulatory and Antimicrobial Activity === | |||
* '''Traditional Use:''' Used to combat infections and normalize bodily humors. | |||
* '''Mechanism & Scientific Evidence:''' Alkaloidal constituents like atisine exhibit significant inhibitory activity against various gram-positive and gram-negative bacteria. Furthermore, the extracts enhance cellular and humoral immune responses in experimental models.<ref name="Immuno2011">Gupta, V., et al. "Immunomodulatory and antimicrobial efficacy of Aconitum heterophyllum roots." Asian Pacific Journal of Tropical Medicine.</ref> | |||
== | == Summary of Therapeutic Profile == | ||
{| class="wikitable sortable" style="text-align: left;" | |||
|+ Therapeutic Applications of *Aconitum heterophyllum* | |||
! Indication | |||
! Active Biomolecules | |||
! Primary Pharmacological Action | |||
|- | |||
| '''Diarrhea & Dysentery (*Atisara*)''' | |||
| Diterpenoid alkaloids, Bitter principles | |||
| Anti-motility, Anti-secretory, Enteric pathogen inhibition | |||
|- | |||
| '''Fever & Inflammation (*Jvara*)''' | |||
| Atisine, Heterophylline | |||
| Antipyretic, Pro-inflammatory cytokine suppression | |||
|- | |||
| '''Microbial Infections (*Krimiroga*)''' | |||
| Alkaloidal fractions | |||
| Broad-spectrum antimicrobial activity | |||
|} | |||
== Safety, Toxicity, and Dosage == | |||
* '''Precautions:''' Raw or unpurified roots contain potent aconite-type alkaloids that can be toxic; hence, strict adherence to classical purification (*Shodhana*) processes is mandatory prior to therapeutic usage. | |||
* '''Standard Therapeutic Dosage:''' | |||
** ''Root Powder (Churna):'' 0.6–2 g daily.<ref name="API" /> | |||
== References == | |||
{{Reflist|refs= | |||
<ref name="API">Anonymous. The Ayurvedic Pharmacopoeia of India. Department of Ayush, Ministry of Health and Family Welfare, Govt. of India, New Delhi, Part I. 1986; Volume I:14</ref> | |||
<ref name="RajaNighantu">Dr. Indradev Tripathi, Raj Nighantu of Pandit Narahari, Pippalyadi Varga, Verse no. 136, Chaukhambha Krishnadas Academy, Varanasi.</ref> | |||
<ref name="Bhavaprakash">Shri Bhavamishra, Bhavaprakash Nighantu, Haritakyadi Varga, Verse no. 186 - 187, Edited by Padmashree Prof. Krushnachandra Chunekar, Reprint Edition, Chaukhambha Bharati Academy, 2015.</ref> | |||
<ref name="Shodhana">Dr. Indradev Tripathi, Raj Nighantu of Pandit Narahari, Pippalyadi Varga, Verse no. 137, Chaukhambha Krishnadas Academy, Varanasi.</ref> | |||
<ref name="Atishara2010">Mehta, D. C., et al. "Evaluation of anti-diarrheal activity of Aconitum heterophyllum root extracts in experimental models." Journal of Ethnopharmacology.</ref> | |||
<ref name="Jvara2014">Sharma, R., et al. "Antipyretic and anti-inflammatory activities of Aconitum heterophyllum root extracts." Phytotherapy Research.</ref> | |||
<ref name="Immuno2011">Gupta, V., et al. "Immunomodulatory and antimicrobial efficacy of Aconitum heterophyllum roots." Asian Pacific Journal of Tropical Medicine.</ref> | |||
}} | |||
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