Sharira Vichaya Sharira: Difference between revisions
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|data7 = Patwardhan K., Shilwant A.A | |data7 = Patwardhan K., Shilwant A.A | ||
|label8 = Editors | |label8 = Editors | ||
|data8 = Patwardhan K., Deole Y.S., Basisht G. | |data8 = Patwardhan K., [[Yogesh Deole|Deole Y.S.]], [[Gopal Basisht|Basisht G.]] | ||
|label9 = Year of publication | |label9 = Year of publication | ||
|data9 = 2020 | |data9 = 2020 | ||
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== Introduction == | == Introduction == | ||
<div style="text-align:justify;"> | <div style="text-align:justify;"> | ||
This sixth chapter of the [[Sharira Sthana]], entitled [[Sharira Vichaya Sharira]](analytical study of the body) follows the chapter on | This sixth chapter of the [[Sharira Sthana]], entitled [[Sharira Vichaya Sharira]](analytical study of the body) follows the chapter on Purusha Vichaya Sharira (detail study of the ''[[purusha]]''). To achieve divine bliss and ''moksha'' (salvation) that the preceding chapter talked about, it is imperative that the body is free from diseases. To achieve a disease-free life, it is of utmost importance to know the components of the body and what vitiates them or affects them, thus, causing diseases or complete destruction of the body, etc. | ||
Overall, the chapter is divided into two broad sections – the first one dealing with all the above mentioned subjects and the second one dealing with embryology, development and growth of various body parts in the fetus. The chapter ends with a very important aspect related to death viz. timely and untimely death. Since death is an inevitability, the discussion about timely and untimely death has been aptly placed here in this chapter after deliberations on the development and growth of an embryo, a person yet to born. | Overall, the chapter is divided into two broad sections – the first one dealing with all the above mentioned subjects and the second one dealing with embryology, development and growth of various body parts in the fetus. The chapter ends with a very important aspect related to death viz. timely and untimely death. Since death is an inevitability, the discussion about timely and untimely death has been aptly placed here in this chapter after deliberations on the development and growth of an embryo, a person yet to born. | ||
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== Vidhi Vimarsha (Applied Inferences) == | == Vidhi Vimarsha (Applied Inferences) == | ||
Concept of analytical knowledge | ===Concept of analytical knowledge === | ||
The concept of analytical knowledge or detailed knowledge of the body elements that is described here is very much similar to the concept of systems biology in contemporary science. | |||
Systems biology studies biological systems by analyzing them (biologically, genetically, or chemically), by monitoring the gene, protein, and informational pathway responses, integrating these data and ultimately, formulating mathematical models that describe the structure of the system and its response to individual variations. Systems biology does not investigate individual genes or proteins one at a time. Rather, it investigates the behavior and relationships of all of the elements in a particular biological system while it is functioning. Thus, the systems biology theory understands the importance of the constituent units of the body as well as their networking. (Timothy Galitski, 2001)<ref> Timothy Galitski, and Leroy Hood. A new approach to decoding life: Systems Biology Annu. Rev. Genomics Hum. Genet. 2001; 2:343–72 </ref> | Systems biology studies biological systems by analyzing them (biologically, genetically, or chemically), by monitoring the gene, protein, and informational pathway responses, integrating these data and ultimately, formulating mathematical models that describe the structure of the system and its response to individual variations. Systems biology does not investigate individual genes or proteins one at a time. Rather, it investigates the behavior and relationships of all of the elements in a particular biological system while it is functioning. Thus, the systems biology theory understands the importance of the constituent units of the body as well as their networking. (Timothy Galitski, 2001)<ref> Timothy Galitski, and Leroy Hood. A new approach to decoding life: Systems Biology Annu. Rev. Genomics Hum. Genet. 2001; 2:343–72 </ref> | ||
A simple example that can illustrate System biology approach is of sickle cell anemia. This disease is caused by a single point mutation at position 6 of the β-chain of hemoglobin, which changes hemoglobin’s oxygen affinity and promotes polymerization under hypoxic conditions. However, individuals with sickle cell disease can present with variety of symptoms which include hemolysis, inflammation, cell adhesion and end-organ ischemia-reperfusion injury and infarction. Patients also experience intermittent painful episodes due to acute vascular obstruction. (Mack KA) <ref> Mack KA, Kato GJ. Sickle cell disease and nitric oxide: A paradigm shift? Int J Biochem Cell Biol. 2006; 38(8): 1237–1243. </ref> There are many reasons for these different clinical manifestations, including the presence of other genes modifying the disease modifying genes (e.g., hemoglobin F). Hence, this example indicates that the knowledge of single gene is not sufficient to understand the disease. There is need to consider other genes or in other words other constituents of the body. [verse 3] | A simple example that can illustrate System biology approach is of sickle cell anemia. This disease is caused by a single point mutation at position 6 of the β-chain of hemoglobin, which changes hemoglobin’s oxygen affinity and promotes polymerization under hypoxic conditions. However, individuals with sickle cell disease can present with variety of symptoms which include hemolysis, inflammation, cell adhesion and end-organ ischemia-reperfusion injury and infarction. Patients also experience intermittent painful episodes due to acute vascular obstruction. (Mack KA) <ref> Mack KA, Kato GJ. Sickle cell disease and nitric oxide: A paradigm shift? Int J Biochem Cell Biol. 2006; 38(8): 1237–1243. </ref> There are many reasons for these different clinical manifestations, including the presence of other genes modifying the disease modifying genes (e.g., hemoglobin F). Hence, this example indicates that the knowledge of single gene is not sufficient to understand the disease. There is need to consider other genes or in other words other constituents of the body. [verse 3] | ||
=== Definition of | === Definition of [[sharira]] and disequilibrium in body elements === | ||
The consciousness manifested in the body is because of the soul. Since the soul does not have any dwelling place, the word bhuta is added to the term ''chetana sthana'' in the text. | The consciousness manifested in the body is because of the soul. Since the soul does not have any dwelling place, the word bhuta is added to the term ''chetana sthana'' in the text. | ||