Changes

This gut leakage and dysbiosis leads to gut inflammation, also disrupt an immune homeostasis. It causes systemic immune activation, neurological disturbances and auto immune diseases. All these predisposing conditions cause ama formation which triggers many complex pathological conditions, act as route cause for many diseases.<ref>Sharma H. Leaky Gut Syndrome, Dysbiosis, Ama, Free Radicals, and Natural Antioxidants. AYU. 2009; 30 (2): 88-105.</ref>

This gut leakage and dysbiosis leads to gut inflammation, also disrupt an immune homeostasis. It causes systemic immune activation, neurological disturbances and auto immune diseases. All these predisposing conditions cause ama formation which triggers many complex pathological conditions, act as route cause for many diseases.<ref>Sharma H. Leaky Gut Syndrome, Dysbiosis, Ama, Free Radicals, and Natural Antioxidants. AYU. 2009; 30 (2): 88-105.</ref>

=== Ama and free radical theory ==

=== Ama and free radical theory ===

<p style='text-align:justify;'>In contemporary sciences, the concept of ama can be related with free radical oxidative damage and autoimmune disorders.<ref name="ref6">J.S. Tripathi, R. H. Singh. Possible Correlates of Free Radicals and Free Radical Mediated Disorders in [[Ayurveda|Ayurveda]] with Special Reference to Bhutagni Vyapara and Ama at Molecular Level. Ancient Science of Life. Vol. No. XIX (1&2) July, August, September, October 99. </ref> </p>

<p style='text-align:justify;'>In contemporary sciences, the concept of ama can be related with free radical oxidative damage and autoimmune disorders.<ref name="ref6">J.S. Tripathi, R. H. Singh. Possible Correlates of Free Radicals and Free Radical Mediated Disorders in [[Ayurveda|Ayurveda]] with Special Reference to Bhutagni Vyapara and Ama at Molecular Level. Ancient Science of Life. Vol. No. XIX (1&2) July, August, September, October 99. </ref> </p>