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''Pakshavadha'' (hemiplegia), ''graha'' (stiffness), ''apatanaka'' (convulsion disorder), ''ardita'' (facial palsy), ''sosha'' (cachexia), ''rajayakshma'' (tuberculosis), ''asthisandhishula'' (pain in bone joints), ''gudabhramsha'' (prolapsed rectum), and diseases of head, heart and urinary bladder are the diseases of middle pathway for disease manifestation.
 
''Pakshavadha'' (hemiplegia), ''graha'' (stiffness), ''apatanaka'' (convulsion disorder), ''ardita'' (facial palsy), ''sosha'' (cachexia), ''rajayakshma'' (tuberculosis), ''asthisandhishula'' (pain in bone joints), ''gudabhramsha'' (prolapsed rectum), and diseases of head, heart and urinary bladder are the diseases of middle pathway for disease manifestation.
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''Jwara'' (fever), ''atisara'' (diarrhea), ''chhardi'' (vomiting), ''alasaka'' (sluggish intestines/ paralytic ileus), ''visuchika'' (cholera), ''kasa'' (cough), ''shwasa'' (dyspnoea), ''hikka'' (hiccups), ''anaha'' (obstructed flatulence), ''udara'' ( abdominal disorders), ''pliha roga'' (diseases of spleen), internal ''visarpa'' (skin disease/ swelling which quickly spreads), ''shvayathu'' (internal swelling), ''gulma'' (abdominal lumps), ''arsha'' (internal piles), and ''vidradhi'' (internal abscess) are the diseases of internal pathway for disease manifestation. [49]
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''[[Jwara]]'' (fever), ''atisara'' (diarrhea), ''chhardi'' (vomiting), ''alasaka'' (sluggish intestines/ paralytic ileus), ''visuchika'' (cholera), ''[[kasa]]'' (cough), ''shwasa'' (dyspnoea), ''hikka'' (hiccups), ''anaha'' (obstructed flatulence), ''udara'' ( abdominal disorders), ''pliha roga'' (diseases of spleen), internal ''visarpa'' (skin disease/ swelling which quickly spreads), ''shvayathu'' (internal swelling), ''gulma'' (abdominal lumps), ''arsha'' (internal piles), and ''vidradhi'' (internal abscess) are the diseases of internal pathway for disease manifestation. [49]
 
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