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*Pharmacological Activity
 
*Pharmacological Activity
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The drug was reported to have antibacterial, anti-allergic, anti-inflammatory, analgesic  and immunomodulatory Activity <ref>Patel Ritesh G, Pathak Nimish L, Rathod Jaimik D, Dr.L.D.Patel and Bhatt Nayna M. Phytopharmacological Properties of  Randia dumetorum  as a Potential Medicinal Tree: An Overview , Journal of Applied Pharmaceutical Science 01 (10); 2011: 24-26. ISSN: 2231-3354.<ref/>. Antileishmanial activity ,antitumor activity and stimulant action on uterus was also reported.<ref> Navneet K. Singh, Arun K. Mishra , Jeetendra K. Gupta , S. Jayalakshmi ,Randia spinosa (poir.): ethnobotany, phytochemistry and pharmacology -a review  International Journal of Pharmaceutical Sciences Review and Research Volume 4 (1), Sep.–Oct.2010</ref>.
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The drug was reported to have antibacterial, anti-allergic, anti-inflammatory, analgesic  and immunomodulatory Activity <ref>Patel Ritesh G, Pathak Nimish L, Rathod Jaimik D, Dr.L.D.Patel and Bhatt Nayna M. Phytopharmacological Properties of  Randia dumetorum  as a Potential Medicinal Tree: An Overview , Journal of Applied Pharmaceutical Science 01 (10); 2011: 24-26. ISSN: 2231-3354.</ref>. Antileishmanial activity ,antitumor activity and stimulant action on uterus was also reported.<ref>Navneet K. Singh, Arun K. Mishra , Jeetendra K. Gupta , S. Jayalakshmi ,Randia spinosa (poir.): ethnobotany, phytochemistry and pharmacology -a review  International Journal of Pharmaceutical Sciences Review and Research Volume 4 (1), Sep.–Oct.2010</ref>.
 
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**Mucosal irritants - Uṣṇa, Tīkṣṇa etc. Guṇas
 
**Mucosal irritants - Uṣṇa, Tīkṣṇa etc. Guṇas
 
Followed by antiperistalsis movements - Electrical stimuli : (prabhava) by stimulating CTZ centers in brain
 
Followed by antiperistalsis movements - Electrical stimuli : (prabhava) by stimulating CTZ centers in brain
      
*Research work on comparative study of Vamana by two different methods:
 
*Research work on comparative study of Vamana by two different methods:
 
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A comparative clinical study on standardization of Vamana Vidhi by classical and traditional methods was carried out<ref>Ranjip Kumar Dass, Nilesh N. Bhatt, Anup B. Thakar,  Vagish Dutt Shukla. Ayu. 2012 Oct-Dec; 33(4): 517–522. doi:  10.4103/0974-8520.110531 </ref>.  Total 50 patients and healthy volunteers were selected irrespective of gender, religion, occupation, etc., from O.P.D. and I.P.D. of Panchakarma Department of Institute for Post Graduate Teaching and Research in Ayurveda, Jamnagar. The patients as well as healthy volunteers were randomly divided into following two groups: One group had performed Vamana by the classical methods according to Charaka and Sushruta Samhita.  Madanphala Pippali was taken in Antarnakha Mushti (making fist) Pramana by the patient's own hand. It was then added in Yashtimadhu Kwatha and kept for one night (previous night of Vamana Karma). In the morning time, it was stirred properly and filtered. Then it was given to the patient in lukewarm state mixing with honey and Saindhav Lavana (rock salt) upto Pittanta Vamana (till bile comes). Before that in early morning, Ghritayukta Yavagu was given to the patient after Abhyanga (massage) and Swedana (fomentation).
A comparative clinical study on standardization of Vamana Vidhi by classical and traditional methods was carried out<ref>Ranjip Kumar Dass, Nilesh N. Bhatt, Anup B. Thakar,  Vagish Dutt Shukla. Ayu. 2012 Oct-Dec; 33(4): 517–522. doi:  10.4103/0974-8520.110531 </ref>.  Total 50 patients and healthy volunteers were selected irrespective of gender, religion, occupation, etc., from O.P.D. and I.P.D. of Panchakarma Department of Institute for Post Graduate Teaching and Research in Ayurveda, Jamnagar. The patients as well as healthy volunteers were randomly divided into following two groups: One group had performed Vamana by the classical methods according to Charaka and Sushruta Samhita.  Madanphala Pippali was taken in Antarnakha Mushti (making fist) Pramana by the patient's own hand. It was then added in Yashtimadhu Kwatha and kept for one night (previous night of Vamana Karma). In the morning time, it was stirred properly and filtered. Then it was given to the patient in lukewarm state mixing with honey and Saindhav Lavana (rock salt) upto Pittanta Vamana (till bile comes). Before that in early morning, Ghritayukta Yavagu was given to the patient after Abhyanga (massage) and Swedana (fomentation).
   
   
 
   
 
In the other group B (traditional group), twenty two individuals had performed Vamana by traditional methods .  In the morning time at first after massage and sudation, milk or Ikshu Rasa was given to the patient upto Aakanthapana (fullness upto throat). Then Madanphala Pippali Churna, Vacha and Saindhav Lavana were taken in a ratio of 4:2:1 part, respectively and a paste was made with honey. It was then given to the patient directly or indirectly by mixing with any liquid media like milk or Ikshu Rasa or Yashtimadhu Phanta. Afterwards, Yashtimadhu Phanta made freshly in the morning was given upto Pittanta Vamana.  
 
In the other group B (traditional group), twenty two individuals had performed Vamana by traditional methods .  In the morning time at first after massage and sudation, milk or Ikshu Rasa was given to the patient upto Aakanthapana (fullness upto throat). Then Madanphala Pippali Churna, Vacha and Saindhav Lavana were taken in a ratio of 4:2:1 part, respectively and a paste was made with honey. It was then given to the patient directly or indirectly by mixing with any liquid media like milk or Ikshu Rasa or Yashtimadhu Phanta. Afterwards, Yashtimadhu Phanta made freshly in the morning was given upto Pittanta Vamana.  

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