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Even though all of the determinants (i.e., signs and symptoms) cannot be explained by rational scientific parameters (as evident by the references above to paranormal and occult sciences), some of these signs and symptoms have been documented and reported as having been experienced by people in various parts of the world. Within the treatise ([[Charaka Samhita]]), physicians have been instructed to thoroughly examine the patient for certain telltale signs that indicate terminal illness and investigate using biomarkers. The treatise then advises physicians to stop any therapeutic treatment being given to such terminal patients and provide them palliative care instead.
 
Even though all of the determinants (i.e., signs and symptoms) cannot be explained by rational scientific parameters (as evident by the references above to paranormal and occult sciences), some of these signs and symptoms have been documented and reported as having been experienced by people in various parts of the world. Within the treatise ([[Charaka Samhita]]), physicians have been instructed to thoroughly examine the patient for certain telltale signs that indicate terminal illness and investigate using biomarkers. The treatise then advises physicians to stop any therapeutic treatment being given to such terminal patients and provide them palliative care instead.
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• Overuse, underuse and misuse of indriya or senses is called Asatmyendriyartha samyoga where inappropriate consumption of this  isolator  insulation of  Ojus or sneha occurs resulting in increase of roukshya or roughness which causes a painful  perception.
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3. Clinical importance of Indriya
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• The first chapter of Sutrasthana  stresses upon the cause of all mental and physical diseases as asatmyendriyarth samyoga (injudicious use of senses), leading to premature deterioration of senses causing shortening of life. (Ch. Su. 1 / 54).
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• Sensory organs are exposed to enormous sensations from the external world, voluntarily or involuntarily, all the time. These sensations are of varying degree of traumatic, unpleasant or pleasant in nature.
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• Whereas the physical body takes limited amount of food and drinks, the senses encounter enormous stimuli, because indriya buddhi (sensory centres in brain) always remains open and active and acts as extension of brain.
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• Constantly sensing such traumatic stimuli, reduces the lifespan of indriya than other organs of body.
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• With this reason Upnishad prays  loudly for life of indriya “ jeevem sharadh shatam, pasyemah shardah shatam, shrinuyamah ..........”
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• To accomplish the optimum span of life, for prevention of disease, promotion of health, and repair of sensorium,  with the judicious uses of all senses, the yam, niyam (Do’s and Don’ts) and sadvritta (code and conducts)  are mentioned in detail in Indriyopakramneeya chapter (Ch.su.8).
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• If a person does not take care of indriya, than the life forces deteriorate prematurely, resulting in death, or become inefficient to carry the sensory functions in the middle of the expected lifespan  or  earlier.
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• This inefficiency of indriya caused by  injudicious use, manifests several signs and symptoms of imminent or instantaneous death.
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• These are categorically described in 12 chapters of indriya sthan, with useful tools for measuring life span, remaining life and  clinical diagnosis of  severity of disease.
 

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