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Any new disease, not mentioned in this text, should be studied with investigation of vitiated ''dosha'' and ''dushya'' (vitiated ''dhatu'' and other body components) first because all endogenous diseases start with vitiation of ''dosha''. The enlisted causative factors elucidated in the detailed history of a patient’s diet, lifestyle, psychological frame and others direct the vitiation of a specific ''dosha''. Then their status (increase or decrease) can be assessed based on the premonitory signs and clinical features, followed by evaluation of  aggravating (''anupashaya'') and pacifying (''upashaya'') factors. The sequence of events in the pathogenesis of a disease is understood and accordingly treatment protocol is formulated.  
 
Any new disease, not mentioned in this text, should be studied with investigation of vitiated ''dosha'' and ''dushya'' (vitiated ''dhatu'' and other body components) first because all endogenous diseases start with vitiation of ''dosha''. The enlisted causative factors elucidated in the detailed history of a patient’s diet, lifestyle, psychological frame and others direct the vitiation of a specific ''dosha''. Then their status (increase or decrease) can be assessed based on the premonitory signs and clinical features, followed by evaluation of  aggravating (''anupashaya'') and pacifying (''upashaya'') factors. The sequence of events in the pathogenesis of a disease is understood and accordingly treatment protocol is formulated.  
 
''Prajnaparadha'' (intellectual errors, or knowingly violating rules) is the chief responsible factor for causation of all endogenous and exogenous diseases. ''Asatmenriyarthasamyoga'' (improper union of senses with their objects) and ''parinama''(time) are other two causative factors . Therefore, this principle points that so called idiopathic diseases of unknown etiology have a definite cause,that needs to be searched and removed for its management.
 
''Prajnaparadha'' (intellectual errors, or knowingly violating rules) is the chief responsible factor for causation of all endogenous and exogenous diseases. ''Asatmenriyarthasamyoga'' (improper union of senses with their objects) and ''parinama''(time) are other two causative factors . Therefore, this principle points that so called idiopathic diseases of unknown etiology have a definite cause,that needs to be searched and removed for its management.
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===Researches on Nidana Sthana===
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A team of researchers compiled all Sanskrit texts of [[Nidana Sthana]] in a project report.<ref>Critical Edition of Charaka Nidana Sthana available from http://ayushportal.nic.in/EMR/LITERARY_FINAL_REPORT-1.pdf downloaded on 17/04/2019</ref>
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==References== 
 
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